Quantifying cerebrospinal fluid dynamics: A review of human neuroimaging contributions to CSF physiology and neurodegenerative disease

Mehta, Neel H.; Suss, Richard A.; Dyke, Jonathan P.; Theise, Neil D.; Chiang, Gloria; Strauß, Sara; Saint-Louis, Leslie A.; Li, Yang; Pahlajani, Silky; Babaria, Vivek; Glodzik, Lidia; Carare, Roxana O.; Leon, Mony J. de

doi:10.1016/j.nbd.2022.105776

Cited by 26 publications

(8 citation statements)

References 148 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In humans, a number of magnetic resonance imaging (MRI) techniques have been developed to assess CSF movement in patients, such as using cardiac-gated phase contrast MRI to examine net CSF flow through the cerebral aqueduct ( Liu et al, 2022 ; Mehta et al, 2022 ). In general, those methods have found a net movement of CSF from the ventricular system (anterograde), although there is considerable variation in calculated CSF flow across methods (reviewed in ( Liu et al, 2022 )).…”

Section: The Choroid Plexus As the Site Of Csf Secretionmentioning

confidence: 99%

Mechanisms of cerebrospinal fluid and brain interstitial fluid production

Xiang

Hua

et al. 2023

Neurobiology of Disease

View full text Add to dashboard Cite

Section: The Choroid Plexus As the Site Of Csf Secretionmentioning

confidence: 99%

Mechanisms of cerebrospinal fluid and brain interstitial fluid production

Xiang

Hua

et al. 2023

Neurobiology of Disease

View full text Add to dashboard Cite

“…To support this protective function, reduced cerebrospinal fluid production and clearance caused exacerbated AD pathologies ( Silverberg et al, 2001 ; Tarasoff-Conway et al, 2015 ). Several neuroimaging modalities have been developed to measure cerebrospinal fluid dynamics ( Mehta et al, 2022 ). MR cisternography and MR myelography were conventionally used for the diagnosis of anatomical cerebrospinal fluid disorders ( Mokri, 2014 ).…”

Section: Other Alzheimer’s Disease Pathophysiology In Relation To Blo...mentioning

confidence: 99%

Contributions of blood–brain barrier imaging to neurovascular unit pathophysiology of Alzheimer’s disease and related dementias

Uchida

Kan

Sakurai

et al. 2023

Front. Aging Neurosci.

View full text Add to dashboard Cite

The blood–brain barrier (BBB) plays important roles in the maintenance of brain homeostasis. Its main role includes three kinds of functions: (1) to protect the central nervous system from blood-borne toxins and pathogens; (2) to regulate the exchange of substances between the brain parenchyma and capillaries; and (3) to clear metabolic waste and other neurotoxic compounds from the central nervous system into meningeal lymphatics and systemic circulation. Physiologically, the BBB belongs to the glymphatic system and the intramural periarterial drainage pathway, both of which are involved in clearing interstitial solutes such as β-amyloid proteins. Thus, the BBB is believed to contribute to preventing the onset and progression for Alzheimer’s disease. Measurements of BBB function are essential toward a better understanding of Alzheimer’s pathophysiology to establish novel imaging biomarkers and open new avenues of interventions for Alzheimer’s disease and related dementias. The visualization techniques for capillary, cerebrospinal, and interstitial fluid dynamics around the neurovascular unit in living human brains have been enthusiastically developed. The purpose of this review is to summarize recent BBB imaging developments using advanced magnetic resonance imaging technologies in relation to Alzheimer’s disease and related dementias. First, we give an overview of the relationship between Alzheimer’s pathophysiology and BBB dysfunction. Second, we provide a brief description about the principles of non-contrast agent-based and contrast agent-based BBB imaging methodologies. Third, we summarize previous studies that have reported the findings of each BBB imaging method in individuals with the Alzheimer’s disease continuum. Fourth, we introduce a wide range of Alzheimer’s pathophysiology in relation to BBB imaging technologies to advance our understanding of the fluid dynamics around the BBB in both clinical and preclinical settings. Finally, we discuss the challenges of BBB imaging techniques and suggest future directions toward clinically useful imaging biomarkers for Alzheimer’s disease and related dementias.

show abstract

“…Two recent reviews have dealt with methods of measuring CSF secretion rate [ 85 ] and using different imaging techniques to examine CSF flow [ 86 ]. There is debate about the relative importance of different CSF outflow pathways (e.g., across cribriform plate, along cranial nerves, via dural lymphatics or arachnoid villi).…”

Section: Elements Of the Blood-csf Barrier And The Csf And Glymphatic...mentioning

confidence: 99%

A year in review: brain barriers and brain fluids research in 2022

Keep

Jones

Hamilton

et al. 2023

Fluids Barriers CNS

View full text Add to dashboard Cite

This aim of this editorial is to highlight progress made in brain barrier and brain fluid research in 2022. It covers studies on the blood-brain, blood-retina and blood-CSF barriers (choroid plexus and meninges), signaling within the neurovascular unit and elements of the brain fluid systems. It further discusses how brain barriers and brain fluid systems are impacted in CNS diseases, their role in disease progression and progress being made in treating such diseases.

show abstract

Quantifying cerebrospinal fluid dynamics: A review of human neuroimaging contributions to CSF physiology and neurodegenerative disease

Cited by 26 publications

References 148 publications

Mechanisms of cerebrospinal fluid and brain interstitial fluid production

Mechanisms of cerebrospinal fluid and brain interstitial fluid production

Contributions of blood–brain barrier imaging to neurovascular unit pathophysiology of Alzheimer’s disease and related dementias

A year in review: brain barriers and brain fluids research in 2022

Contact Info

Product

Resources

About