Quantifying risk factors for microscopic colitis: A nationwide, retrospective cohort study

Are Drugs Associated with Microscopic Colitis? A Systematic Review and Meta-Analysis

“…Of these 45 articles, 13 studies fulfilled the selection criteria and were included in the final analysis. Eight studies [ 11 , 13 , 15 , 16 , 17 , 18 , 19 , 20 ] used random control adjusted for age, sex, GP practice, or birth year.…”

“…Nine studies [ 8 , 9 , 12 , 13 , 17 , 18 , 19 , 21 , 22 ] reported the odds of microscopic colitis in patients using proton pump inhibitors. Studies by Masclee et al [ 21 ] and Pascua et al [ 22 ] reported two different Odds ratios based on the control groups (Community random and diarrhea controls).…”

“…Higher pooled odds of MC were observed in patients taking SSRI (OR 2.12(95% CI 1.27–2.96, I 2 96.46%). We included nine different odds ratios from 8 studies [ 8 , 9 , 12 , 17 , 18 , 19 , 21 , 22 ] to calculate the pooled odds ratio because Pascua et al [ 22 ] provided two ratios based on two different control groups. Greater odds of MC were seen in patients taking SSRIs when compared to random health controls (OR 3.23, 95% CI 1.54–4.92, I 2 98.31%), whereas on the contrary, no difference in odds of MC was noted in comparison to the diarrhea control group (OR 0.96, 95% CI 0.49–1.42, I 2 37.89%) ( Figure 3 ).…”

“…Eight studies [ 8 , 9 , 12 , 13 , 17 , 18 , 19 , 21 ] provided the adjusted odds of MC in patients who were currently taking NSAIDs or were on them in the past. Patients taking NSAIDs had greater odds of developing MC (OR 2.02, 95% CI 1.33–2.70, I 2 92.70%).…”

“…Pooled odds of MC in statin users were 1.74 (95% CI 1.19–2.30, I 2 96.36%) calculated from 9 adjusted odd ratios obtained from 7 studies [ 8 , 9 , 17 , 18 , 19 , 21 , 22 ]. Higher odds of MC were seen in patients taking statins compared to the healthy random control group (OR 2.23, 95% CI 1.41–3.06, I 2 98.11%).…”