Quantifying visual allodynia across migraine subtypes: the Leiden Visual Sensitivity Scale

Perenboom, Matthijs J.L.; Najafabadi, Amir H Zamanipoor; Zielman, Ronald; Carpay, Johannes A.; Ferrari, Michel D.

doi:10.1097/j.pain.0000000000001343

Cited by 45 publications

(71 citation statements)

References 40 publications

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“…The association between MwA and higher photophobia scores is consistent with the association between MwA and greater visual stimulus induced interictal activation of visual processing brain regions in functional neuroimaging studies. Previous studies have hypothesized that aura is related to greater photophobia symptoms; however, the majority of these studies did not demonstrate a statistically significant difference between MwA and MwoA . Our study expanded upon these prior findings using a large sample size of patients, including individuals with high frequency migraine, and using the validated PAQ to assess photophobia.…”

Section: Discussionmentioning

confidence: 83%

“…Previous studies have hypothesized that aura is related to greater photophobia symptoms; however, the majority of these studies did not demonstrate a statistically significant difference between MwA and MwoA. 20,21,23,24 Bolded P values are those that reached our pre-defined threshold for statistical significance (P < .05). This table summarizes the results of the linear regression model for HQ scores.…”

Section: Discussionmentioning

confidence: 96%

“…Previous studies on the relationship between headache frequency and sensory hypersensitivities have had mixed results. One 2018 study found that photosensitivity, as measured by the Leiden Visual Sensitivity Scale, is more common in people with chronic migraine than those with episodic migraine . However, a 2014 study found no correlation between interictal photosensitivity, measured using the Visual Discomfort Scale, and average monthly migraine frequency .…”

Section: Discussionmentioning

confidence: 99%

“…Several neuroimaging studies have shown increased interictal stimulus‐induced activation of the visual cortex and increased visual network connectivity in migraine with aura (MwA) compared to migraine without aura (MwoA) . However, prior studies comparing photosensitivity symptoms in MwA vs MwoA have reported conflicting results, with most studies failing to show a difference between groups . The relationship between MwA with symptoms of phonophobia and CA has been under‐investigated.…”

Section: Introductionmentioning

confidence: 99%

“…[19][20][21][22] However, prior studies comparing photosensitivity symptoms in MwA vs MwoA have reported conflicting results, with most studies failing to show a difference between groups. 20,21,23,24 The relationship between MwA with symptoms of phonophobia and CA has been underinvestigated. Because photophobia, phonophobia, and CA have been shown to be positively associated with one another, 25 it is possible that MwA could also be associated with phonophobia and CA, in addition to photophobia.…”

Section: Introductionmentioning

confidence: 99%

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Sensory Hypersensitivity Symptoms in Migraine With vs Without Aura: Results From the American Registry for Migraine Research

et al. 2020

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Background and Objectives Migraine with aura (MwA) is associated with increased brain hyper‐responsiveness to visual stimuli and increased visual network connectivity relative to migraine without aura (MwoA). Despite this, prior studies have provided conflicting results regarding whether MwA is associated with higher photophobia symptom scores compared to MwoA. The relationships between MwA and other types of sensory hypersensitivity, such as phonophobia and cutaneous allodynia (CA), have not been previously investigated. The purpose of this cross‐sectional observational study was to investigate whether MwA is associated with greater symptoms of photophobia, phonophobia, and CA compared to MwoA. Methods This analysis included 321 migraine patients (146 MwA; 175 MwoA) who had been enrolled into the American Registry for Migraine Research. The diagnosis of either MwoA or MwA was determined by headache specialists using ICHD diagnostic criteria. Patients completed the Photosensitivity Assessment Questionnaire, the Hyperacusis Questionnaire, and the Allodynia Symptom Checklist. Mean or median values were compared between groups. Regression models were created to analyze the relationship between MwA with photophobia scores, hyperacusis scores, and the presence of interictal CA. Results Those with MwA had higher mean photophobia scores than those with MwoA (4.1 vs 3.0, P = .0003). MwA was positively associated with photophobia symptom severity (B = 0.50 [SE = 0.14], P = .0003), after controlling for age, patient sex, and headache frequency. Aura was not associated with hyperacusis symptom severity (B = 0.07 [SE = 0.08], P = .346) or the presence of interictal CA (OR 1.33 [95% CI 0.70‐2.53], P = .381). Conclusion MwA is associated with higher photophobia symptom scores compared to MwoA. Aura is not associated with greater hyperacusis or interictal allodynia scores. These findings complement prior imaging and neurophysiologic studies that demonstrated MwA to be associated with hyper‐responsiveness of brain visual processing regions. The findings suggest that MwA is associated specifically with visual hypersensitivity, as opposed to being associated with a general hypersensitivity to multiple types of sensory stimuli.

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Section: Discussionmentioning

confidence: 83%