2012
DOI: 10.1248/bpb.b12-00210
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Quantitation and Human Monocyte Cytotoxicity of the Polymerization Agent 1-Hydroxycyclohexyl Phenyl Ketone (Irgacure 184) from Three Brands of Aqueous Injection Solution

Abstract: In this study, levels of the photoinitiator 1-hydroxycyclohexyl phenyl ketone (1-HCHPK) in aqueous injection solutions were analyzed by GC-MS. In our previous studies, photoinitiators such as 2-methyl-4′-(methylthio)-2-morpholinopropiophenone (MTMP) were detected in intravenous (i.v.) injection bag solution, and they were found to be cytotoxic to human monocytes. Therefore, we hypothesized that 1-HCHPK might display similarly cytotoxicity. The purpose of this study was to quantitate the amount of contaminants … Show more

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Cited by 19 publications
(7 citation statements)
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“…Interestingly, 1-HCHPK has recently been reported as toxicant leaching from polyethylene ampoules used for intravenous injections [ 100 ]. Such pilot GC-MS analysis highlighted its limited detection capability for substances that are polar and non-volatile.…”
Section: Compatibility Of Am Substrata With Biological Applicationmentioning
confidence: 99%
“…Interestingly, 1-HCHPK has recently been reported as toxicant leaching from polyethylene ampoules used for intravenous injections [ 100 ]. Such pilot GC-MS analysis highlighted its limited detection capability for substances that are polar and non-volatile.…”
Section: Compatibility Of Am Substrata With Biological Applicationmentioning
confidence: 99%
“…Photoinitiators become outstanding candidates for coating onto the silica nanoparticles as they can increase dispersity in the organic matrix and exhibit a low migration tendency after being incorporated into the polymer matrix . For food packaging materials, migration becomes a critical issue as those unreacted photoinitiators can migrate into the food and raise health issues. In recent years, researchers have grafted different commercially available photoinitiators onto the surface of Silica NPs to achieve photoactive nanoparticles. For instance, a type II photoinitiator, 2-chlorothioxanthone (CTX), was grafted onto the Silica NPs and photo-cross-linked with epoxy acrylate resin (EA) to yield the corresponding composites .…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, nine PIs have been detected in UV curable resin 3D printing products, with total concentrations up to 21 μg/g and a median of 4 μg/g . PIs such as MBB, PI-184, and PI-907 have been found in healthcare injection solutions. They are also essential components of curable dental fillings. PI-651 and EDMAB have been identified in the leachates of dental filling materials, while PIs including PI-184 and Benzil have been confirmed to be released from wood-based furniture coatings …”
Section: Occurrence Of Pismentioning
confidence: 99%