Quantitation of Metal Content in the Silver-Assisted Growth of Gold Nanorods

Orendorff, Christopher J.; Murphy, Catherine J.

doi:10.1021/jp0570972

Cited by 673 publications

(839 citation statements)

References 40 publications

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“…24 Interestingly, our results show that the type of heating the AuNRs undergo has a significant influence on the composition of the protein corona. As seen in Figures 2, 3, and Supporting Information Tables S1−S4, there are significant differences in the composition of the protein corona following photoinduced versus conventional thermal heating, under both in vitro and in vivo simulated conditions.…”

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confidence: 72%

“…22,23 For instance, AuNRs with an aspect ratio of 3.5 or greater possess a strong longitudinal surface plasmon resonance in the near-IR region of the spectrum where light can easily penetrate biological tissue to depths of up to 1.0 cm. 22,24 In addition, gold nanorods are potentially appealing hyperthermia agents, due to the variety of functionalization strategies that exist to control the surface chemistry of these AuNRs. Such surface functionalization can enhance both the biocompatibility and targeting opportunities of AuNRs both in vivo and in vitro.…”

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confidence: 99%

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Variation of Protein Corona Composition of Gold Nanoparticles Following Plasmonic Heating

et al. 2013

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It is well recognized that the primary interaction of most biological environments with nanoparticles (NPs) is strongly influenced by a long-lived ("hard") protein corona that surrounds the NP and remains strongly adsorbed to its surface. The amount and composition of associated proteins in the corona adsorbed onto the NPs is related to several important factors, including the physicochemical properties of the NPs and the composition of the protein solution. Here, for the first time, it is shown that plasmonic heat induction (by laser activation) leads to significant changes in the composition of the hard protein corona adsorbed on low aspect ratio gold nanorods. Using mass spectrometry, several proteins in the corona were identified whose concentrations change most substantially as a result of photoinduced (plasmonic) heating versus simple thermal heating. Molecular modeling suggests that the origin of these changes in protein adsorption may be the result of protein conformational changes in response to much higher local temperatures that occur near the gold nanorods during photoinduced, plasmonic heating. These results may define new applications in vivo for NPs with hyperthermia capability and better define the likely interactions of cells with NPs after plasmonic heating. Potential changes in the protein corona following hyperthermia treatment may influence the final biological fate of plasmonic NPs in clinical applications and help elucidate safety considerations for hyperthermia applications.

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confidence: 72%

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confidence: 99%

Variation of Protein Corona Composition of Gold Nanoparticles Following Plasmonic Heating

et al. 2013

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“…21 The detailed mechanism of surfactant-directed growth of gold nanoparticles is under active investigation. [27][28][29][30] Although the gold nanostar samples have marked structural heterogeneity, their extinction spectra exhibit broad yet welldefined peaks in the visible and NIR, as seen in Figure 1C. It has been well established theoretically and experimentally that elongated gold and silver nanoparticles feature a longitudinal plasmon resonance that red shifts from ca.…”

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confidence: 88%

Optical Properties of Star-Shaped Gold Nanoparticles

2006

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Here we report the synthesis, structure, and optical properties of ca. 100 nm star-shaped gold nanoparticles. Single particle spectroscopy measurements revealed that these nanoparticles have multiple plasmon resonances resulting in polarization-dependent scattering with multiple spectral peaks, which correspond to the different tips on the star-shaped structure. The plasmon resonances were also found to be extremely sensitive to the local dielectric environment.The size-and shape-dependent physical properties of inorganic nanoparticles provide tunable materials with broad potential applications, 1 and the fabrication of structurally complex nanoparticles further enhances their functionality. For example, the synthesis of semiconductor nanowires with core/shell heterostructures creates electronic junctions within the nanowire that can act as tunable nanophotonic lightemitting diodes. 2 The synthesis of branched quantum dots 3 could enable studies of entangled quantum states and quantum information processing within individual nanoparticles. 4 Metallic nanoparticles also benefit from the formation of complex structures. Magnetic "barcode" nanowires that contain periodic domains of NiFe/Cu 5 and Pt/Cu 6 offer tunable magnetic properties. Noble metal nanoparticles exhibit localized surface plasmon resonances resulting in strong optical extinction at visible wavelengths. The localized surface plasmon resonance (LSPR) enables applications including biological and chemical sensing, 7-9 biological imaging labels, 10-12 and nanoscale optical waveguides. 13 The formation of more complex metal nanostructures, such as metallodielectric gold nanoshells 14 and gold nanocages, 15 shifts the LSPR resonance to the near-infrared (NIR) enabling significant diagnostic and therapeutic biomedical applications. 16,17 Here we describe the synthesis and optical properties of branched star-shaped gold nanoparticles which incorporate polarization-dependent scattering with multiple spectral peaks and strong dielectric sensitivity into a single structure.Due to the symmetric face-centered cubic lattice of gold nanoparticles, the formation of anisotropic structures requires a selective capping agent during growth. For example, roomtemperature synthesis of gold nanorods with 97% yield has recently been demonstrated by seed-mediated growth directed by the surfactant cetyltrimethylammonium bromide (CTAB), 18,19 and the process can be scaled up to 100 mL batches. 20 In addition to nanorods, a variety of anisotropic gold nanoparticle shapes, including cubes, prisms, and branched nanoparticles, can be fabricated using surfactants [21][22][23] or other capping agents. 24 In seed-mediated, surfactantdirected nanorod growth, surfactant-stabilized seed nanoparticles are synthesized through the reduction of gold chloride by sodium borohydride and then added to a gold chloride growth solution that also contains surfactant. We have found that when the surfactant-stabilized seed is replaced by a commercially available colloid (10 nm diameter gold ...

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“…30 Cary 500 UV-VIS-NIR Spectrophotometer (Varian Inc.) was used to scan the absorption profiles of NRs solutions. Based on their SPR long , we estimated the extinction coefficients to be 4.6 x 10 9 M -1 cm -1 and 8.6 x 10 9 M -1 cm -1 for nanocapsules and nanobones respectively.…”

Section: Nanorod Characterizationmentioning

confidence: 99%

Selective Release of Multiple DNA Oligonucleotides from Gold Nanorods

et al. 2008

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Combination therapy, or the use of multiple drugs, has been proven to be effective for complex diseases, but the differences in chemical properties and pharmacokinetics can be challenging in term of the loading, delivering, and releasing multiple drugs. Here we demonstrate that we can load and selectively release two different DNA oligonucleotides from two different gold nanorods. DNA was loaded on the nanorods via thiol conjugation. Selective releases were induced by selective melting of gold nanorods via ultrafast laser irradiation at the nanorods' longitudinal surface plasmon resonance peaks. Excitation at one wavelength could selectively melt one type of gold nanorods and selectively release one type

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Quantitation of Metal Content in the Silver-Assisted Growth of Gold Nanorods

Cited by 673 publications

References 40 publications

Variation of Protein Corona Composition of Gold Nanoparticles Following Plasmonic Heating

Variation of Protein Corona Composition of Gold Nanoparticles Following Plasmonic Heating

Optical Properties of Star-Shaped Gold Nanoparticles

Selective Release of Multiple DNA Oligonucleotides from Gold Nanorods

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