Quantitative analysis of contralateral hemisphere hypertrophy and sensorimotor performance in adult rats following unilateral neonatal ischemic-hypoxic brain injury

Jansen, Elizabeth M.; Low, Walter C.

doi:10.1016/0006-8993(95)01288-5

Cited by 40 publications

(18 citation statements)

References 15 publications

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“…Animals with more severe cortical deficits can also show significant recovery, such as it has been described for placing reflex following neonatal cortical damage (Barth and Stanfield, 1990). The compensatory changes have been shown to be individually different, and can be responsible for different degrees of recovery after brain injuries (Jansen and Low, 1996). Compensatory changes have been demonstrated in hippocampal neurons following MSG treatment .…”

Section: Discussionmentioning

confidence: 97%

Development of neurological reflexes and motor coordination in rats neonatally treated with monosodium glutamate

et al. 2005

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Monosodium glutamate (MSG) treatment of neonatal rats causes neuronal degeneration in various brain areas and leads to several neurochemical, endocrinological and behavioral alterations. However, relatively little is known about the development of neurological reflexes and motor coordination of these animals. Therefore, the aim of the present study was to examine the neurobehavioral development of newborn rats treated with MSG. Rats received MSG at postnatal days 1, 3, 5, 7, and 9. Appearance of neural reflexes and reflex performance as well as motor coordination were examined for 5 weeks after birth. The efficacy of MSG treatment was confirmed by histological examination of the arcuate nucleus. We found that MSG treatment delayed the appearance of forelimb placing, forelimb grasp and righting reflexes, besides the retarded somatic development. The treated pups performed surface righting in significantly longer times. Also, worse performance was observed in the foot-fault and rota-rod tests. However, MSG-treated rats reached control levels by the end of the fifth postnatal week. These results show that MSG treatment does not cause permanent alterations in the neurobehavioral development, only delays the appearance of some reflexes and leads to temporary changes in reflex performance and motor coordination signs.

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Section: Discussionmentioning

confidence: 97%

Development of neurological reflexes and motor coordination in rats neonatally treated with monosodium glutamate

et al. 2005

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“…These changes are associated with maintenance of an increased ipsilateral corticospinal projection from the undamaged hemisphere. The cells of origin of the induced aberrant ipsilateral axons are more widely distributed and distinct from the cells of origin of the crossed or contralateral corticospinal projection (Huttenlocher and Raichelson, 1989;Jansen and Low, 1996;O'Leary et al, 1992;Reinoso and Castro, 1989). There is no evidence for double labelling of corticospinal neurones in neonatally hemispherectomised animals that in adulthood had spinal cord injection of fluorescent tracers (Reinoso and Castro, 1989).…”

Section: Article In Pressmentioning

confidence: 89%

“…Substantial lesions of the sensorimotor cortex or corticospinal tract in sub-primate mammals early in postnatal life lead to hypertrophy of the undamaged motor cortex and corticospinal projection which has an increased number of corticospinal axons D'Amato, 1970, 1977;Huttenlocher and Raichelson, 1989;Jansen and Low, 1996;Rouiller et al, 1991;Uematsu et al, 1996). These changes are associated with maintenance of an increased ipsilateral corticospinal projection from the undamaged hemisphere.…”

Section: Article In Pressmentioning

confidence: 94%

Corticospinal tract development and its plasticity after perinatal injury

Eyre

2007

Neuroscience & Biobehavioral Reviews

267

226

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“…17 In contrast, Andine et al 1 found decreased weight of the hemisphere contralateral to the injured side in rats. Jansen et al, 18 however, demonstrated histologically assessed hypertrophy of the contralateral hemisphere in adult rats after a perinatal HI insult. Sample assessment-related methodological differences may explain the conflicting literature related to the appearance of the contralateral hemisphere.…”

Section: Discussionmentioning

confidence: 99%

Late Measures of Brain Injury After Neonatal Hypoxia–Ischemia in Mice

Ten

Tang

et al. 2004

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Background and Purpose-This work was undertaken to determine to what degree long-term neurofunctional outcome of neonatal hypoxic-ischemic (HI) brain injury in mice correlates with anatomical extent of cerebral damage assessed by magnetic resonance imaging (MRI) and histopathology. Methods-On postnatal day 7, mice were subjected to HI. At 7 to 9 weeks after HI neurofunctional outcome was assessed by water-maze, rota-rod, and open-field test performance, followed by cerebral MRI and histopathology evaluation.

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Quantitative analysis of contralateral hemisphere hypertrophy and sensorimotor performance in adult rats following unilateral neonatal ischemic-hypoxic brain injury

Cited by 40 publications

References 15 publications

Development of neurological reflexes and motor coordination in rats neonatally treated with monosodium glutamate

Development of neurological reflexes and motor coordination in rats neonatally treated with monosodium glutamate

Corticospinal tract development and its plasticity after perinatal injury

Late Measures of Brain Injury After Neonatal Hypoxia–Ischemia in Mice

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