Quantitative analysis of the inflammatory reaction surrounding sutures commonly used in operative procedures and the relation to postsurgical adhesion formation

Bakkum, Erica A.; Dalmeijer, Remco A.J.; Verdel, M.J.C.; Hermans, J.; Blitterswijk, Clemens A. van; Trimbos, J. Baptist

doi:10.1016/0142-9612(95)91042-w

Cited by 39 publications

(20 citation statements)

References 16 publications

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“…Besides the mechanical injury to the peritoneum itself, foreign body material and especially suture materials are well known to be key factors in adhesion formation [7,8,11,23,24]. Even if mechanical injury is the most obvious reason for adhesion formation, it has to be considered that several studies demonstrate that suture granuloma is the most often detected reason for foreign body-related peritoneal adhesions [23,[25][26][27]. In an experimental trial, Bakkum et al could even show that the extent of postsurgical peritoneal adhesions was mostly related to suture characteristics [26].…”

Section: Discussionmentioning

confidence: 99%

Influence of small intestinal serosal defect closure on leakage rate and adhesion formation: a pilot study using rabbit models

Binnebösel

Klink

Grommes

et al. 2010

Langenbecks Arch Surg

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Closure of isolated serosal injuries with resorbable suture material was associated with an adhesion formation in distressing certainty, whereas no leakage or fistula formation could be observed at all. Further studies are needed to clarify the impact of serosal defect closure in particular on leakage rate and fistula formation, e.g., with pre-existing adhesions, in case of multiple serosal injuries or with a pre-existing peritonitis.

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Section: Discussionmentioning

confidence: 99%

Influence of small intestinal serosal defect closure on leakage rate and adhesion formation: a pilot study using rabbit models

Binnebösel

Klink

Grommes

et al. 2010

Langenbecks Arch Surg

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“…In order to avoid adhesions, we can use liquids in peritoneal cavity or materials coating the prostheseis 14,21,22,23 . We decided for the use of a coating in the polypropylene prosthesis because the function of the adhesions is still controversial.…”

Section: Resultsmentioning

confidence: 99%

Peritoneostomy with latex coated polypropylene: experimental study in rats

Claudio

Filho

2006

Acta Cir. Bras.

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Purpose: To evaluate if latex coated polypropylene mesh leads to less adhesions formation. Methods: 90 rats were distributed in three groups. Group I (control) was submitted to median laparotomy and posterior synthesis; Group II (polypropylene) was submitted to a segment resection of the abdominal wall, and the defect was corrected with a polypropylene mesh; Group III using the new material (latex coated polypropylene). After 45 days the euthanasia procedure was done and the adhesions were evaluated in 2 ways: 1) classification in a grading system; 2) evaluation of the adhesion area, which was calculated by resection of the adhesions after dying with Indian blue ink. Results: The classification in a grading system showed that Group III animals had less adhesions formation (P<0.05), but the evaluation of the adhesion area did not show any difference (P>0.05). The severe complications (fistula, evisceration and obstruction), which were lethal, were not reduced by the latex coated material. Conclusion: Latex coated polypropylene causes fewer adhesion formations than polypropylene alone, although it does not diminish the severe early complications. Key words: Polypropylenes. Latex. Surgical Mesh. RESUMO Objetivo:Avaliar se o revestimento da tela de polipropileno com látex leva a menor formação de aderências. Métodos: Foram utilizados 90 ratos, distribuídos em três grupos de 30: grupo I (controle) animais submetidos a laparotomia mediana e posterior síntese; grupo II (polipropileno) ressecção de segmento da parede abdominal e síntese com tela de polipropileno; grupo III, (polipropileno revestido por látex). Eutanásia foi realizada após 45 dias e as aderências avaliadas sob duas formas: 1) classificação em graus; 2) avaliação da área aderida, calculada corando-se o segmento da parede contendo as aderências que posteriormente foram ressecadas produzindo uma região clara em contraste com o restante da peça, corada. Resultados: Na avaliação por meio de graus, o grupo III apresentou menor formação de aderências (p<0,05), mas quanto a avaliação da área aderida não houve diferença (p>0,05). As complicações graves não foram reduzidas pelo revestimento por látex (p>0,05). Conclusão: O revestimento da tela de polipropileno por látex leva a menor formação de aderências, porém não diminui as complicações graves precoces.

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“…firmed [9][10][11]. Riddik et al [12] and Sanz et al [13] found that the inflammatory reaction to polyglycolic acid salt is higher than that of polyglactin 910.…”

Section: Discussionmentioning

confidence: 99%

Angiogenic Effects of Suture Biomaterials

et al. 2001

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Angiogenesis is a limiting step of inflammation and wound healing. Although laboratory tests for the evaluation of the angiogenetic effects of biomaterials are available, no investigations have been performed. In this study we examine the angiogenetic effect of suture biomaterials in the rat mesenteric window model. Absolute controls had laparotomy only, controls had mesenteric window wounding, test groups had the insertion of either a thread of collagen, polyglactin 910, polyglycolic acid salt, silk or of a titanium clip. We considered the percentage area of the mesenteric window covered by neovessels. After 7 days, negligible angiogenesis was found in absolute controls, significant angiogenesis in controls, collagen, polyglactin 910 and polyglycolic acid salt treated rats, without differences between treatments. A significant increase of angiogenesis in comparison to the control group was found in rats treated with silk and titanium. Ultramicroscopy of the neovessels showed specific changes of their architecture in titanium-treated rats. In conclusion, angiogenesis during wound healing is differently influenced by the suture material used. Silk and titanium stimulated angiogenesis in a different way.

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Quantitative analysis of the inflammatory reaction surrounding sutures commonly used in operative procedures and the relation to postsurgical adhesion formation

Cited by 39 publications

References 16 publications

Influence of small intestinal serosal defect closure on leakage rate and adhesion formation: a pilot study using rabbit models

Influence of small intestinal serosal defect closure on leakage rate and adhesion formation: a pilot study using rabbit models

Peritoneostomy with latex coated polypropylene: experimental study in rats

Angiogenic Effects of Suture Biomaterials

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