Quantitative and Chemical Fingerprint Analysis for the Quality Evaluation of Platycodi Radix Collected from Various Regions in China by HPLC Coupled with Chemometrics

Lu, Haiyang; Ju, Mengzhen; Chu, Shanshan; Xu, Tao; Huang, Yuzhe; Chan, Qingyun; Peng, Hua-Sheng; Gui, Shuangying

doi:10.3390/molecules23071823

Cited by 26 publications

(16 citation statements)

References 21 publications

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“…All evaluation tests confirmed that there was little or no herbal extract-excipient interaction indicative that the granules formed were stable [39,40,41]. The formulation technology employed is beneficial for industrial applications, in the potential ease of scaling up, ease of formulation, enhanced stability of therapeutic principles and reproducibility coupled with the use of unsophisticated equipment, A simple, convenient, cost effective, and environmentally friendly method is a beneficial approach.…”

Section: Discussionmentioning

confidence: 85%

Strategies for formulation of effervescent granules of an herbal product for the management of typhoid fever

Adi-Dako

Kumadoh

Egbi

et al. 2021

Heliyon

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Herbal medicines are currently being adopted as alternatives to orthodox medicines for the management of drugresistant and emerging multidrug-resistant microbial strains of various diseases, including typhoid fever. A herbal decoction, MA 001, manufactured by the Centre for Plant Medicine Research (CPMR), has been used for the treatment of typhoid fever for at least two decades in Ghana with desirable outcomes. MA 001 is formulated from Citrus aurantifolia, Spondias mombin, Latana camara, Bidens pilosa, Trema occidentalis, Psidium guajava, Morinda lucida, Vernonia amygdalina, Persea americana, Paulina pinnatta, Momordia charantia and Cnestis ferruguinea medicinal plants. The low palatability and compliance to treatment due to the bulky nature of the decoction poses challenges in its optimum use. This study sought to design and formulate the therapeutic components of the aqueous herbal decoction of MA 001 into an optimal solid dosage form of effervescent granules to improve the delivery of MA 001 as well as increase patient compliance and convenience of product handling. The methods involved pre-formulation studies on the suitability of effervescent vehicles, formulation and evaluation of effervescent granules for drug excipient interactions using high performance liquid chromatography analysis. The findings indicate that the effervescent granules were suitable for use in the delivery of the therapeutic constituents for the treatment of typhoid fever as done with the decoction due to minimal herbal extract-excipient interaction.

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Section: Discussionmentioning

confidence: 85%

Strategies for formulation of effervescent granules of an herbal product for the management of typhoid fever

Adi-Dako

Kumadoh

Egbi

et al. 2021

Heliyon

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“…For these reasons, individual brands of herbal medicines from the same plant species may differ significantly in their biological activity and chemical composition. Therefore, quality control for chemical consistency is essential to ensure the efficacy of herbal medicines (Viapiana et al 2016;Lu et al 2018). Health organizations, including the US Food and Drug Administration (FDA), the World Health Organization (WHO), and the European Medicines Agency (EMA), have recommended this strategy for the evaluation of quality and similarity in herbal medicines (Xie et al 2019;Zhu et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Development and application of a chemical profiling method for the assessment of the quality and consistency of the Pelargonium sidoides extract

Yu¹,

Kim²,

Yoon

et al. 2021

J Anal Sci Technol

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The evaluation of chemical similarity is very significant for the evaluation and standardization of the quality of herbal medicines as the biological activity of herbal medicines depends on the composition and proportion of many individual components. Many health organizations have recommended chemical profiling for the quality and consistency evaluation of herbal medicines. In this study, chemical profiling was performed to evaluate the similarity between batches of Pelargonium sidoides maltodextrin mixture (PMM) from EPs® 7630, a Pelargonium sidoides extract preparation. For chemical profile analysis, 7 common peaks were selected from 27 different PMM batches and specificity, linearity, accuracy, and precision tests were performed to develop the analytical method. The Pearson correlation coefficients of the similarity for all 27 batches manufactured over the years were higher than 0.90, indicating that quality consistency is well ensured over the years. This profiling method confirms the chemical profile of various commercial products using not only PMM but also Pelargonium sidoides extract and shows that it can be applied to standardization of quality.

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“…A HPLC-PAD method was developed for the quality evaluation of ASR. In consideration of the complexity of TCM, similarity analysis (SA), hierarchical clustering analysis (HCA) and principal component analysis (PCA) which were usually performed in analysis, 37 , 44 , 75 - 78 were used to reasonably define the class of ASR and to efficiently evaluate the quality of ASR. We expected that the method would be helpful for the quality control of ASR and it can provide a reference for the quality evaluation of products prepared by traditional decoction technology, such as classical preparations.…”

Section: Introductionmentioning

confidence: 99%

Study on the Fingerprints and Quality Evaluation of Angelica Sinensis Radix by HPLC Coupled With Chemometrics Based on Traditional Decoction Process of ACPTCM

Zhang

Chen

et al. 2020

Dose-Response

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Objective: To establish a HPLC fingerprints evaluation method for Angelica Sinensis Radix (ASR) based on traditional decoction process of Ancient Classical Prescriptions of Traditional Chinese Medicine (ACPTCM). Methods: The fingerprints of 10 batches of ASR were further evaluated by chemometrics methods. The similarity analyzed with “Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine 2004A,” and hierarchical clustering analysis (HCA) and principal component analysis (PCA) were performed by SPSS (version 22.0, SPSS Inc., Chicago, IL, USA). Results: There were 12 common peaks, and the similarity degrees of 10 batches of samples were more than 0.923 and showed that all the samples from different origins were of good consistency. The samples were divided into 4 clusters by HCA. The results of PCA showed that the 3 factors were chosen, the quality of samples could be evaluated basically. The comprehensive score results show that the ASR with Lot.Nos.DG-18007, DG-18008 in Weiyuan County, Gansu and DG-18009 produced in Minle County, Gansu Province rank among the top 3 in all samples. Conclusions: These results demonstrated that the combination of HPLC chromatographic fingerprint and chemometrics offers an efficient and reliable approach for quality evaluation of ASR from different sources as Ancient Classical Prescriptions ingredients.

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Quantitative and Chemical Fingerprint Analysis for the Quality Evaluation of Platycodi Radix Collected from Various Regions in China by HPLC Coupled with Chemometrics

Cited by 26 publications

References 21 publications

Strategies for formulation of effervescent granules of an herbal product for the management of typhoid fever

Strategies for formulation of effervescent granules of an herbal product for the management of typhoid fever

Development and application of a chemical profiling method for the assessment of the quality and consistency of the Pelargonium sidoides extract

Study on the Fingerprints and Quality Evaluation of Angelica Sinensis Radix by HPLC Coupled With Chemometrics Based on Traditional Decoction Process of ACPTCM

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