Quantitative and qualitative bone imaging: A review of synchrotron radiation microtomography analysis in bone research

Obata, Yoshihiro; Bale, Hrishikesh; Barnard, Harold; Parkinson, Dilworth; Alliston, Tamara; Acevedo, Claire

doi:10.1016/j.jmbbm.2020.103887

Cited by 17 publications

(5 citation statements)

References 129 publications

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“…Tools that require synchrotron radiation, which delivers high-resolution imaging of bone structure and mineralization 27,61,76,92 but is limited to very few researchers, are reviewed briefly here and thoroughly elsewhere. [93][94][95][96]…”

Section: Choosing Tools To Study Lcs Bone Qualitymentioning

confidence: 99%

“…The use of high-resolution microcomputed tomography (µCT) to monitor bone, including LCS network architecture, is the subject of several recent reviews [93][94][95] and is therefore discussed only briefly here. µCT allows for non-destructive three-dimensional analysis of internal bone tissue structure and mineralization.…”

Section: High-resolution Microcomputed Tomographymentioning

confidence: 99%

“…µCT allows for non-destructive three-dimensional analysis of internal bone tissue structure and mineralization. 93 Standard µCT does not achieve adequate resolution to visualize the LCS. Higher resolution µCT is now available as laboratory systems.…”

Section: High-resolution Microcomputed Tomographymentioning

confidence: 99%

See 2 more Smart Citations

Lacunar-canalicular bone remodeling: Impacts on bone quality and tools for assessment

Vahidi

Rux

Sherk

et al. 2021

Bone

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Section: Choosing Tools To Study Lcs Bone Qualitymentioning

confidence: 99%

Section: High-resolution Microcomputed Tomographymentioning

confidence: 99%

See 1 more Smart Citation

Lacunar-canalicular bone remodeling: Impacts on bone quality and tools for assessment

Vahidi

Rux

Sherk

et al. 2021

Bone

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“…Based on the loading type, these devices can be categorized into in situ tensile loading, axial fatigue loading, [112] rotary bending, et cetera; based on the loading environment, they can be ambient temperature, cryogenic, hightemperature, vacuum, et cetera. Some renowned researchers in the field include Professor Buffière et al [113][114][115][116][117][118] from Institut National des Sciences Appliquées de Lyon, France, Professor Toda et al [119][120][121][122][123][124] from Kyushu University, Japan, Professor Bale et al [125,126] from the University of California, United States, Professor Withers et al [127][128][129][130][131][132] from the University of Manchester, United Kingdom, and Professor Wu et al [133][134][135] from Southwest Jiaotong University, China. A summary of their contribution to the field is listed in Table 1.…”

Section: Applications In Mechanical Performancementioning

confidence: 99%

Recent Progress of Synchrotron X-Ray Imaging and Diffraction on the Solidification and Deformation Behavior of Metallic Materials

Peng

Miao

Sun

et al. 2021

Acta Metall. Sin. (Engl. Lett.)

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Characterizing the microstructure and deformation mechanism associated with the performances and properties of metallic materials is of great importance in understanding the microstructure-property relationship. The past few decades have witnessed the rapid development of characterization techniques from optical microscopy to electron microscopy, although these conventional methods are generally limited to the sample surface because of the intrinsic opaque nature of metallic materials. Advanced synchrotron radiation (SR) facilities can produce X-rays with strong penetrability and high spatiotemporal resolution, and thereby enabling the non-destructive visualization of full-field structural information in three dimensions. Tremendous endeavors were devoted to the 3rd generation SR over the past three decades, in which X-ray beams have been focused down to 100 nm. In this paper, recent progresses on SR-related characterization technologies were reviewed, with particular emphases on the fundamentals of synchrotron X-ray imaging and synchrotron X-ray diffraction, as well as their applications in the in situ observations of material preparation (e.g., in situ dendrite growth during solidification) and service under extreme environment (e.g., in situ mechanics). Future innovations toward next-generation SR and newly emerging SRbased technologies such as dark-field X-ray microscopy and Bragg coherent X-ray diffraction imaging were also advocated.

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“…SRµCT provides 3D reconstructions of the bone’s microstructure that are used to measure the size and arrangement of different features within the bone, such as the osteocyte lacunae 20 , 21 . Additionally, SRµCT is a densitometry technique, meaning the images provide information on the bone’s tissue mineral density (TMD) or mineralization.…”

Section: Introductionmentioning

confidence: 99%

Spatial control of perilacunar canalicular remodeling during lactation

Sieverts,

Yee,

Nemani

et al. 2024

Sci Rep

Self Cite

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Osteocytes locally remodel their surrounding tissue through perilacunar canalicular remodeling (PLR). During lactation, osteocytes remove minerals to satisfy the metabolic demand, resulting in increased lacunar volume, quantifiable with synchrotron X-ray radiation micro-tomography (SRµCT). Although the effects of lactation on PLR are well-studied, it remains unclear whether PLR occurs uniformly throughout the bone and what mechanisms prevent PLR from undermining bone quality. We used SRµCT imaging to conduct an in-depth spatial analysis of the impact of lactation and osteocyte-intrinsic MMP13 deletion on PLR in murine bone. We found larger lacunae undergoing PLR are located near canals in the mid-cortex or endosteum. We show lactation-induced hypomineralization occurs 14 µm away from lacunar edges, past a hypermineralized barrier. Our findings reveal that osteocyte-intrinsic MMP13 is crucial for lactation-induced PLR near lacunae in the mid-cortex but not for whole-bone resorption. This research highlights the spatial control of PLR on mineral distribution during lactation.

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Quantitative and qualitative bone imaging: A review of synchrotron radiation microtomography analysis in bone research

Cited by 17 publications

References 129 publications

Lacunar-canalicular bone remodeling: Impacts on bone quality and tools for assessment

Lacunar-canalicular bone remodeling: Impacts on bone quality and tools for assessment

Recent Progress of Synchrotron X-Ray Imaging and Diffraction on the Solidification and Deformation Behavior of Metallic Materials

Spatial control of perilacunar canalicular remodeling during lactation

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