Quantitative and Qualitative Evaluation of Renal Injury Induced by Shock Waves Delivered with the Siemens C Generator

Dongen, J.J.W. Van; Grossi, Francesco Saverio; Bosman, FT; Schröder, Fritz H.

doi:10.1089/end.1993.7.379

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…Macroscopic and histologic examination of SW-exposed kidneys reveals typical renal vascular and parenchymal injury, comparable to that seen in earlier animal experiments. 5,6,8,12 These correlations will also be found in the clinical SW application (CT and MRI examination after SWL treatment). 15,16 The number of SWs correlates with the extent of the injured renal tissue.…”

Section: Discussionmentioning

confidence: 76%

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The Isolated Perfused Kidney: Anin VitroTest System for Evaluation of Renal Tissue Damage Induced by High-Energy Shockwaves Sources

Bergsdorf

Thüroff

Chaussy

2005

Journal of Endourology

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Most of our knowledge of shockwave-induced renal damage is based on animal experiments and clinical observation. We developed a tissue model using isolated porcine kidneys perfused with Berliner Blau dye in physiologic saline using a Ureteromat Perez-Castro peristaltic pump connected to the renal artery. Reproducible results were obtained under a variety of experimental conditions. Further refinements of the model might consist of interposition of tissue layers in the shockwave path or simulation of ventilatory movements.

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Section: Discussionmentioning

confidence: 76%

“…[1][2][3][4][5][6][7][8][9][10][11][12] The aim of the present study was to develop an in vitro tissue model that enables reproducible histopathologic evaluation of SW-induced renal trauma and to find a substitute for animal experiments.…”

Section: Introduction E Xtracorporial Shockwave Lithotripsy Hasmentioning

confidence: 99%

The Isolated Perfused Kidney: Anin VitroTest System for Evaluation of Renal Tissue Damage Induced by High-Energy Shockwaves Sources

Bergsdorf

Thüroff

Chaussy

2005

Journal of Endourology

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“…The pig kidney has often been used as a urological model for different techniques and for training [Evan et al, 1991;McDougall et al, 1993;Rassweiler et al, 1993;Van Dongen et al, 1993;Earp, 2003;Katz et al, 2003;Collyer et al, 2004;Hammond et al, 2004] because of the similarities with the human kidney [Sampaio et al, 1998;Pereira-Sampaio et al, 2004Bagetti Filho et al, 2008]. Moreover, other species have also been used for urologic experimental studies, such as the dog [Stephenson et al, 1996;Campbell et al, 1998;Kosieradzki et al, 2003;Sekhon et al, 2003;Ames et al, 2005;Mangino et al, 2005] and rabbit [Demirbas et al, 2004;Akay et al, 2005;Seckiner et al, 2006;Tyritzis et al, 2007].…”

Section: Introductionmentioning

confidence: 99%

The Bovine Kidney as an Experimental Model in Urology: External Gross Anatomy

Carvalho

Filho

Henry

et al. 2008

Cells Tissues Organs

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The objective of this work was to obtain and record detailed and accurate measurements of the bovine kidney and to compare these new data with findings in humans. Thirty-eight bovine kidneys were used. The total number of lobes, along with the number of lobes located in the cranial polar, caudal polar and hilar regions, were recorded. Several measurements of the kidneys were made and evaluated. The hilar region presents the greatest length (mean of 76.87 mm) of the 3 renal regions of the kidney. The large area of the bovine renal hilus could make access to hilar structures easier than in the human kidney. The coefficient of variation for renal length was small (8.14%), while the coefficient of variation for the lobar number was high (26.82%). The number of renal lobes ranged from 13 to 35, with a mean of 20.62. The hilar region presents the highest number of lobes, while the cranial pole presents the lowest. The number of lobes in the cranial and caudal poles increases with the width of these regions. This is different from the hilar region, in which the lobar number increases with the length of the hilus. These data indicate that the adult bovine kidney can be used as a model for certain urologic procedures, but researchers must be aware that there are some major differences between the adult bovine kidney and the human kidney, as indicated by the data reported in this paper.

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A new electromagnetic shock-wave generator “SLX-F2” with user-selectable dual focus size: ex vivo evaluation of renal injury

et al. 2007

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Storz Medical AG (Kreutzlingen/Switzerland) has developed a new electromagnetic shockwave (SW) generator, the "SLX-F2", which allows the user to choose between a small-focus, high-pressure treatment regime or a wide-focus, low-pressure option. The aim of this study was to investigate, under standardized conditions, the impact of these two different treatment regimes on SW-induced renal injury. SW-induced renal injury was investigated by using the standardized model of the perfused ex vivo kidney. SWs were applied under ultrasound control in the parenchyma of a kidney pole. Different SW numbers (20, 50, 125, 250, 500, 1,000) were applied in three groups: group A was treated with a wider focus (80 MPa), groups B (60 MPa) and C (120 MPa) with a smaller focus (each parameter setting was repeated ten-fold). Disintegration capacity (measured by crater volume in cubes of plaster of Paris) was the same in groups A and C. After SW exposure, barium sulphate suspension was perfused through the renal artery. The maximum diameter (mm) of the extravasation in the cortex, representing the extent of vascular injury, was measured on X-ray mammography films. H&E staining was performed. In all three groups (A, B, C) a higher number of SWs caused the diameter of the extravasate to increase, with statistical significance appearing at 1,000 shots versus 20 shots (p < 0.05). Vascular injury was not influenced by the focal size and positive peak pressure at identical SW numbers applied. Histology of the focal area showed gap-like defects. Our ex vivo data show that renal vascular injury is independent of the focal diameter of the SW generator at the same peak positive pressure and disintegration power. This confirms the in vivo findings that show renal injury caused by SW as being related to the number of SWs administered. Clinical studies are needed to investigate whether there is any advantage to offering both treatment regimes in one SW machine-for example, by using the "wide-focus, low-pressure" option for kidney stones and the "small-focus, high-pressure" regimen for stones in the ureter. The renal injury caused by either regime remains comparable.

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Quantitative and Qualitative Evaluation of Renal Injury Induced by Shock Waves Delivered with the Siemens C Generator

Cited by 7 publications

References 6 publications

The Isolated Perfused Kidney: Anin VitroTest System for Evaluation of Renal Tissue Damage Induced by High-Energy Shockwaves Sources

The Isolated Perfused Kidney: Anin VitroTest System for Evaluation of Renal Tissue Damage Induced by High-Energy Shockwaves Sources

The Bovine Kidney as an Experimental Model in Urology: External Gross Anatomy

A new electromagnetic shock-wave generator “SLX-F2” with user-selectable dual focus size: ex vivo evaluation of renal injury

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