Quantitative and Selective Surface Plasmon Resonance Response Based on a Reduced Graphene Oxide–Polyamidoamine Nanocomposite for Detection of Dengue Virus E-Proteins

Omar, Nur Alia Sheh; Fen, Yap Wing; Abdullah, Jaafar; Sadrolhosseini, Amir Reza; Kamil, Yasmin Mustapha; Fauzi, Nurul Illya Muhamad; Hashim, Hazwani Suhaila; Mahdi, Mohd Adzir

doi:10.3390/nano10030569

Cited by 72 publications

(50 citation statements)

References 69 publications

(66 reference statements)

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“…A composite of reduced graphene oxide and polyamidoamine (PAMAM) dendrimers is described for the detection of the E-proteins of the serotype 2 of dengue virus (DENV 2). The detection format consisted of an immunoassay in which monoclonal antibodies were immobilized on self-assembled, dithiobis (succinimidyl undecanoate) amine-activated layers [ 50 ]. The characterization of analytical parameters involved the determination of affinity-binding constants, detection accuracy, and figure of merit values for the minimum E-proteins’ concentration (0.08 pM) while the assay selectivity was tested against E- proteins of Zika virus ( Figure 10 ).…”

Section: Biosensing Strategiesmentioning

confidence: 99%

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Recent Progress in Plasmonic Biosensing Schemes for Virus Detection

Mauriz

2020

Sensors

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The global burden of coronavirus disease 2019 (COVID-19) to public health and global economy has stressed the need for rapid and simple diagnostic methods. From this perspective, plasmonic-based biosensing can manage the threat of infectious diseases by providing timely virus monitoring. In recent years, many plasmonics’ platforms have embraced the challenge of offering on-site strategies to complement traditional diagnostic methods relying on the polymerase chain reaction (PCR) and enzyme-linked immunosorbent assays (ELISA). This review compiled recent progress on the development of novel plasmonic sensing schemes for the effective control of virus-related diseases. A special focus was set on the utilization of plasmonic nanostructures in combination with other detection formats involving colorimetric, fluorescence, luminescence, or Raman scattering enhancement. The quantification of different viruses (e.g., hepatitis virus, influenza virus, norovirus, dengue virus, Ebola virus, Zika virus) with particular attention to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was reviewed from the perspective of the biomarker and the biological receptor immobilized on the sensor chip. Technological limitations including selectivity, stability, and monitoring in biological matrices were also reviewed for different plasmonic-sensing approaches.

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Section: Biosensing Strategiesmentioning

confidence: 99%

“…Inset: SPR time response upon introduction of 0.08 to 1 pM of dengue virus (DENV 2) E-proteins. Adapted with permission from Omar et al [ 50 ] Copyright © (2020) MDPI (under the terms and conditions of the Creative Commons CC BY License).…”

Section: Figurementioning

confidence: 99%

Recent Progress in Plasmonic Biosensing Schemes for Virus Detection

Mauriz

2020

Sensors

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“…Direct methods, exploiting graphene nanotechnology, for the rapid virus detection, have been only marginally investigated in the past, and no critical discussion has been reported in successive literature reviews [ 96 , 97 ].…”

Section: Graphene-based Strategies In the Diagnosis Of Viral Diseamentioning

confidence: 99%

Graphene-Based Strategies in Liquid Biopsy and in Viral Diseases Diagnosis

et al. 2020

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Graphene-based materials are intriguing nanomaterials with applications ranging from nanotechnology-related devices to drug delivery systems and biosensing. Multifunctional graphene platforms were proposed for the detection of several typical biomarkers (i.e., circulating tumor cells, exosomes, circulating nucleic acids, etc.) in liquid biopsy, and numerous methods, including optical, electrochemical, surface-enhanced Raman scattering (SERS), etc., have been developed for their detection. Due to the massive advancements in biology, material chemistry, and analytical technology, it is necessary to review the progress in this field from both medical and chemical sides. Liquid biopsy is considered a revolutionary technique that is opening unexpected perspectives in the early diagnosis and, in therapy monitoring, severe diseases, including cancer, metabolic syndrome, autoimmune, and neurodegenerative disorders. Although nanotechnology based on graphene has been poorly applied for the rapid diagnosis of viral diseases, the extraordinary properties of graphene (i.e., high electronic conductivity, large specific area, and surface functionalization) can be also exploited for the diagnosis of emerging viral diseases, such as the coronavirus disease 2019 (COVID-19). This review aimed to provide a comprehensive and in-depth summarization of the contribution of graphene-based nanomaterials in liquid biopsy, discussing the remaining challenges and the future trend; moreover, the paper gave the first look at the potentiality of graphene in COVID-19 diagnosis.

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“…It was demonstrated that SPR sensor has the ability to detect pregnancy associated plasma protein A2, which is a metalloproteinase that plays multiple roles in fetal development and postnatal growth [35]. Several studies were reported on using SPR sensor as a new strategy to detect influenza nucleoprotein [36], avian influenza A H7N9 virus [37], maize chlorotic mottle virus [38], herpes simplex virus (HSV) [39], cancer cell line (HeLa cells) with biomarker Rhodamine 6G related to cancer tumors [40], nonstructural protein 1 of Zika virus [41], non-human pathogen feline calicivirus (FCV) [42], and dengue virus (DENV) [43][44][45][46].…”

Section: The Importance Of Spr Biosensors In the Medical Diagnosismentioning

confidence: 99%

The Principle of Nanomaterials Based Surface Plasmon Resonance Biosensors and Its Potential for Dopamine Detection

Eddin

Fen

2020

Molecules

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For a healthy life, the human biological system should work in order. Scheduled lifestyle and lack of nutrients usually lead to fluctuations in the biological entities levels such as neurotransmitters (NTs), proteins, and hormones, which in turns put the human health in risk. Dopamine (DA) is an extremely important catecholamine NT distributed in the central nervous system. Its level in the body controls the function of human metabolism, central nervous, renal, hormonal, and cardiovascular systems. It is closely related to the major domains of human cognition, feeling, and human desires, as well as learning. Several neurological disorders such as schizophrenia and Parkinson’s disease are related to the extreme abnormalities in DA levels. Therefore, the development of an accurate, effective, and highly sensitive method for rapid determination of DA concentrations is desired. Up to now, different methods have been reported for DA detection such as electrochemical strategies, high-performance liquid chromatography, colorimetry, and capillary electrophoresis mass spectrometry. However, most of them have some limitations. Surface plasmon resonance (SPR) spectroscopy was widely used in biosensing. However, its use to detect NTs is still growing and has fascinated impressive attention of the scientific community. The focus in this concise review paper will be on the principle of SPR sensors and its operation mechanism, the factors that affect the sensor performance. The efficiency of SPR biosensors to detect several clinically related analytes will be mentioned. DA functions in the human body will be explained. Additionally, this review will cover the incorporation of nanomaterials into SPR biosensors and its potential for DA sensing with mention to its advantages and disadvantages.

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Quantitative and Selective Surface Plasmon Resonance Response Based on a Reduced Graphene Oxide–Polyamidoamine Nanocomposite for Detection of Dengue Virus E-Proteins

Cited by 72 publications

References 69 publications

Recent Progress in Plasmonic Biosensing Schemes for Virus Detection

Recent Progress in Plasmonic Biosensing Schemes for Virus Detection

Graphene-Based Strategies in Liquid Biopsy and in Viral Diseases Diagnosis

The Principle of Nanomaterials Based Surface Plasmon Resonance Biosensors and Its Potential for Dopamine Detection

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