“…However, despite that the neuronal precursors of patients with BD have shorter microtubules, no differences were observed in that current. Thus, it is possible that in addition to alteration in microtubule organization in SZ neurons, a reduction in channel density, diminished channel unitary conductance, or reduced trafficking, may occur to explain the reduced amplitude of the L-type Ca 2+ current (Tuckwell, 2011).…”
“…However, despite that the neuronal precursors of patients with BD have shorter microtubules, no differences were observed in that current. Thus, it is possible that in addition to alteration in microtubule organization in SZ neurons, a reduction in channel density, diminished channel unitary conductance, or reduced trafficking, may occur to explain the reduced amplitude of the L-type Ca 2+ current (Tuckwell, 2011).…”
Basic Fibroblast growth Factor, or FGF-2, has been shown to promote neuronal survival and neurite outgrowth in dissociated neurons from the embryonic chick ciliary ganglion; in these effects the propose that this complex behaviour can be due to a perturbation in PIP 2 levels at the plasmamembrane.
“…Apparently, return from inactivation to the resting state can proceed at such a continuous depolarized potential, and quite small depolarizations are sufficient to trigger renewed activity. It is known that activation of the L-type channel does not necessarily conform to a classical high-voltage characteristic (14,27).…”
Belz M, Willenborg M, Görgler N, Hamada A, Schumacher K, Rustenbeck I. Insulinotropic effect of high potassium concentration beyond plasma membrane depolarization.
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