Quantitative Assessment of Diffusion-Weighted MR Imaging in Patients with Primary Rectal Cancer: Correlation with FDG-PET/CT

Gu, Jin; Khong, Pek‐Lan; Wang, Silun; Chan, Queenie; Law, Wai‐Lun; Zhang, Jingbo

doi:10.1007/s11307-010-0433-7

Cited by 76 publications

(72 citation statements)

References 38 publications

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“…Ho et al (17) found no significant correlation between ADC min and SUV max in patients with primary cervical tumor. In that study, however, a significantly inverse correlation between the relative ADC min (defined as ADC min / ADC mean ratio) and relative SUV max was observed in patients with adeno- The authors concluded that the significant negative correlation between ADC and SUV suggests an association between tumor cellularity and metabolic activity in primary rectal adenocarcinoma (18). Neoadjuvant chemoradiotherapy has become a standard treatment for locally advanced rectal cancer.…”

Section: Discussionmentioning

confidence: 88%

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Correlation of minimum apparent diffusion coefficient with maximum standardized uptake on fluorodeoxyglucose PET-CT in patients with rectal adenocarcinoma

Erden²,

No³

et al. 2013

Diagn Interv Radiol

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ABDOMINAL IMAGINGORIGINAL ARTICLE PURPOSE The aim of this study was to retrospectively assess the correlation between minimum apparent diffusion coefficient (ADC min ) values obtained from diffusion-weighted magnetic resonance imaging (MRI) and maximum standardized uptake values (SUV max ) obtained from positron emission tomography-computed tomography (PET-CT) in rectal cancer. MATERIALS AND METHODSForty-one patients with pathologically confirmed rectal adenocarcinoma were included in this study. For preoperative staging, PET-CT and pelvic MRI with diffusion-weighted imaging were performed within one week (mean time interval, 3±1 day). For ADC measurements, the region of interest (ROI) was manually drawn along the border of each hyperintense tumor on b=1000 s/mm 2 images. After repeating this procedure on each consecutive tumor-containing slice to cover the entire tumoral area, ROIs were copied to ADC maps. ADC min was determined as the lowest ADC value among all ROIs in each tumor. For SUV max measurements, whole-body images were assessed visually on transaxial, sagittal, and coronal images. ROIs were determined from the lesions observed on each slice, and SUV max values were calculated automatically. The mean values of ADC min and SUV max were compared using Spearman's test. RESULTSThe mean ADC min was 0.62±0.19×10 -3 mm 2 /s (range, 0.368-1.227×10 -3 mm 2 /s), the mean SUV max was 20.07±9.3 (range, 4.3-49.5). A significant negative correlation was found between ADC min and SUV max (r=-0.347; P = 0.026). CONCLUSIONThere was a significant negative correlation between the ADC min and SUV max values in rectal adenocarcinomas. D iffusion-weighted imaging (DWI) is a widely used technique for disease evaluation in oncology (1, 2). In rectal cancer, the applications of DWI include tumor detection, tumor characterization, distinguishing tumor tissue from nontumor tissue, and monitoring and predicting treatment response (3-8). For local staging of rectal cancer, adding DWI to conventional magnetic resonance imaging (MRI) yields better identification of tumor borders and locoregional lymph nodes than conventional MRI alone (9, 10).The apparent diffusion coefficient (ADC) map obtained from DWI shows the freedom of water diffusion, and values calculated on the map are useful parameters in tissue characterization. By performing diffusion-weighted (DW) MRI with at least two diffusion weightings, or b values, the differential signal attenuation at different b values can be used to calculate the ADC (2). Regardless of the tumor type and location, the ADC values reflect tumor morphology, including the cellular density, integrity of cell membrane, and nuclear-to-cytoplasm ratio (11,12).Positron emission tomography/computed tomography (PET-CT) has become a crucial method in cancer imaging, both for diagnosis and staging, as well as for offering prognostic information based on tumor response. In PET-CT, the standardized uptake value (SUV) is a measure of fluorodeoxyglucose (FDG) uptake, which has been shown to be helpful in estab...

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Section: Discussionmentioning

confidence: 88%

“…To our knowledge, few studies have evaluated the relationship between ADC and SUV in cancer patients (16)(17)(18). The aim of the present study was to retrospectively assess the correlation between the minimum ADC (ADC min ) on DWI and maximum SUV (SUV max ) values from FDG PET-CT in rectal cancer.…”

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confidence: 99%

Correlation of minimum apparent diffusion coefficient with maximum standardized uptake on fluorodeoxyglucose PET-CT in patients with rectal adenocarcinoma

Erden²,

No³

et al. 2013

Diagn Interv Radiol

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“…A novel functional parameter-termed total lesion glycolysis (TLG) and defined as the standardized uptake value (SUV) multiplied by metabolic tumor volume (MTV)-has been described previously (17). TLG integrates both anatomic and biologic data and has been shown to predict prognosis in breast, colorectal, and lung cancers (18)(19)(20)(21)(22). However, the prognostic value of TLG in patients with NPC has not been sufficiently evaluated.…”

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confidence: 99%

Prognostic Significance of ¹⁸F-FDG PET Parameters and Plasma Epstein-Barr Virus DNA Load in Patients with Nasopharyngeal Carcinoma

Chang¹,

Tsang²,

Liao³

et al. 2012

J Nucl Med

105

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The plasma concentration of Epstein-Barr virus (EBV) DNA is associated with tumor burden and prognosis in patients with nasopharyngeal carcinoma (NPC), but data on the relationship between viral load and 18 F-FDG PET functional parameters are lacking. We examined the association of 18 F-FDG PET functional parameters and EBV DNA load with the clinicopathologic characteristics and clinical outcomes of patients with NPC. Methods: One hundred eight patients with NPC who underwent 18 F-FDG PET before treatment were included in this study. We determined total lesion glycolysis (TLG) of the primary tumor, the cervical nodes, and their combination and the maximal standardized uptake value of the primary tumor and cervical lymph nodes. EBV DNA was measured by real-time polymerase chain reaction. Results: EBV DNA was significantly associated with total TLG (R 2 5 0.589). Total TLG values had the highest correlation with EBV DNA load and were significantly associated with tumor, nodal, and overall stages. However, tumor TLG greater than the median (.65 g) was the only parameter significantly associated with overall, local recurrence-free, disease-free, and distant metastasis-free survivals (P 5 0.033, 0.014, ,0.001, and 0.023, respectively). After allowance for potential confounders, tumor TLG retained its independent significance for overall and disease-free survival rates (P 5 0.045 and 0.006, respectively). Conclusion: Total TLG values are primarily associated with tumor burden and clinical stage, whereas tumor TLG is the best predictor of patient survival after treatment.

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“…Because DW-MRI is completely non-invasive, does not require ionizing radiation or injection of contrast material, and does not cause patient discomfort, it is a potentially powerful tool in the detection of rectosigmoid cancer. In addition, this technique can be easily added to an MR examination protocol because it requires only a minimal prolongation of the examination time (20)(21)(22)(23). It would be a useful adjunct to conventional sequences.…”

Section: Discussionmentioning

confidence: 99%

The value of diffusion-weighted magnetic resonance imaging in the differential diagnosis in diffuse bowel wall thickening

Solak

Genç²,

Solak³

et al. 2013

Turk J Gastroenterol

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Quantitative Assessment of Diffusion-Weighted MR Imaging in Patients with Primary Rectal Cancer: Correlation with FDG-PET/CT

Cited by 76 publications

References 38 publications

Correlation of minimum apparent diffusion coefficient with maximum standardized uptake on fluorodeoxyglucose PET-CT in patients with rectal adenocarcinoma

Correlation of minimum apparent diffusion coefficient with maximum standardized uptake on fluorodeoxyglucose PET-CT in patients with rectal adenocarcinoma

Prognostic Significance of ¹⁸F-FDG PET Parameters and Plasma Epstein-Barr Virus DNA Load in Patients with Nasopharyngeal Carcinoma

The value of diffusion-weighted magnetic resonance imaging in the differential diagnosis in diffuse bowel wall thickening

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Quantitative Assessment of Diffusion-Weighted MR Imaging in Patients with Primary Rectal Cancer: Correlation with FDG-PET/CT

Cited by 76 publications

References 38 publications

Correlation of minimum apparent diffusion coefficient with maximum standardized uptake on fluorodeoxyglucose PET-CT in patients with rectal adenocarcinoma

Correlation of minimum apparent diffusion coefficient with maximum standardized uptake on fluorodeoxyglucose PET-CT in patients with rectal adenocarcinoma

Prognostic Significance of 18F-FDG PET Parameters and Plasma Epstein-Barr Virus DNA Load in Patients with Nasopharyngeal Carcinoma

The value of diffusion-weighted magnetic resonance imaging in the differential diagnosis in diffuse bowel wall thickening

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Prognostic Significance of ¹⁸F-FDG PET Parameters and Plasma Epstein-Barr Virus DNA Load in Patients with Nasopharyngeal Carcinoma