Quantitative assessment of rat bone regeneration using complex master-slave optical coherence tomography

Luca, Ruxandra Elena; Todea, Carmen; Duma, Virgil-Florin; Bradu, Adrian; Podoleanu, Adrian G.H.

doi:10.21037/qims.2019.05.03

Cited by 21 publications

(27 citation statements)

References 37 publications

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“…The control group animals were always characterized as "empty cavity" or "clot", while the intervention groups contained animals that underwent treatment. Nine studies used male animals [12,15,18,20,22,33,37,46,47] and seven used male and female animals [48][49][50][51][52][53][54], while only one study did not describe the gender of the subjects [45].…”

Section: Inclusion Of Studies Quality Of Studies and Test Subjectsmentioning

confidence: 99%

“…Considering all the articles included in this review, the application of PBMT in bone lesions was verified in rats in 15 articles, five of which involved the calvaria [12,20,22,45,47], nine the femur [37,46,[48][49][50][51][52][53][54] and one the mandibular branch [15]. The two articles employing rabbits involved the calvaria [33] and tibia [18].…”

Section: Inclusion Of Studies Quality Of Studies and Test Subjectsmentioning

confidence: 99%

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Photobiomodulation Therapy (PBMT) Applied in Bone Reconstructive Surgery Using Bovine Bone Grafts: A Systematic Review

et al. 2019

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The use of low-level laser therapy (LLLT) with biomodulatory effects on biological tissues, currently called photobiomodulation therapy (PBMT), assists in healing and reduces inflammation. The application of biomaterials has emerged in bone reconstructive surgery, especially the use of bovine bone due to its biocompatibility. Due to the many benefits related to the use of PBMT and bovine bones, the aim of this research was to review the literature to verify the relationship between PBMT and the application of bovine bone in bone reconstruction surgeries. We chose the PubMed/MEDLINE, Web of Science, and Scopus databases for the search by matching the keywords: “Bovine bone AND low-level laser therapy”, “Bovine bone AND photobiomodulation therapy”, “Xenograft AND low-level laser therapy”, and “Xenograft AND photobiomodulation therapy”. The initial search of the three databases retrieved 240 articles, 18 of which met all inclusion criteria. In the studies concerning animals (17 in total), there was evidence of PBMT assisting in biomaterial-related conduction, formation of new bone, bone healing, immunomarker expression, increasing collagen fibers, and local inflammation reduction. However, the results disagreed with regard to the resorption of biomaterial particles. The only human study showed that PBMT with bovine bone was effective for periodontal regeneration. It was concluded that PBMT assists the process in bone reconstruction when associated with bovine bone, despite divergences between applied protocols.

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Section: Inclusion Of Studies Quality Of Studies and Test Subjectsmentioning

confidence: 99%

Section: Inclusion Of Studies Quality Of Studies and Test Subjectsmentioning

confidence: 99%

Photobiomodulation Therapy (PBMT) Applied in Bone Reconstructive Surgery Using Bovine Bone Grafts: A Systematic Review

et al. 2019

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“…Our previous studies, using the same method of evaluation, also showed the capacity of micro-CT technique to play a fundamental role in the advanced characterization of laser-treated sites [71]. Another technique which can be successful for such a research strategy is optical coherence tomography (OCT) [49,[72][73][74]: its advantage is that it can be applied for in vivo assessments, using handheld scanning probes in the oral cavity [75,76]. Moreover, good agreement between OCT and micro-CT analyses was found in our previous studies [77].…”

Section: Discussionmentioning

confidence: 96%

“…In the present study, as well as in a previous one [49], we evaluated the effect of photobiomodulation on bone regeneration process, using rat calvarial defects filled with xenograft, previously coated with collagen membrane and then exposed to laser irradiation.…”

Section: Discussionmentioning

confidence: 98%

Osteogenic Potential of Bovine Bone Graft in Combination with Laser Photobiomodulation: An Ex Vivo Demonstrative Study in Wistar Rats by Cross-Linked Studies Based on Synchrotron Microtomography and Histology

Luca

Giuliani

Mănescu

et al. 2020

IJMS

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Background: Alveolar bone defects are usually the main concern when planning implant treatments for the appropriate oral rehabilitation of patients. To improve local conditions and achieve implant treatments, there are several methods used for increasing bone volume, among which one of the most successful, versatile, and effective is considered to be guided bone regeneration. The aim of this demonstrative study was to propose an innovative analysis protocol for the evaluation of the effect of photobiomodulation on the bone regeneration process, using rat calvarial defects of 5 mm in diameter, filled with xenograft, covered with collagen membrane, and then exposed to laser radiation. Methods: The animals were sacrificed at different points in time (i.e., after 14, 21, and 30 days). Samples of identical dimensions were harvested in order to compare the results obtained after different periods of healing. The analysis was performed by cross-linking the information obtained using histology and high-resolution synchrotron-based tomography on the same samples. A comparison was made with both the negative control (NC) group (with a bone defect which was left for spontaneous healing), and the positive control (PC) group (in which the bone defects were filled with xenografts and collagen membrane without receiving laser treatment). Results: We demonstrated that using photobiomodulation provides a better healing effect than when receiving only the support of the biomaterial. This effect has been evident for short times treatments, i.e., during the first 14 days after surgery. Conclusion: The proposed analysis protocol was effective in detecting the presence of higher quantities of bone volumes under remodeling after photobiomodulation with respect to the exclusive bone regeneration guided by the xenograft.

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“…In conclusion, the results presented in this study prove that OCT has advantages (radiation-free technique and superior resolution), as well as the capability of being utilized in dentistry. Also, results from another related study on OCT in dentistry [7] prove that this imaging technique could be utilized alongside radiographs as a daily-basis technique and that OCT can be useful by both dentists and dental technicians [26,27].…”

Section: Discussionmentioning

confidence: 99%

A combination of imaging techniques for dental medicine: from X-rays radiography and 3D CBCT to OCT

Erdelyi

Duma

Dobre

et al. 2020

Biomedical Spectroscopy, Microscopy, and Imaging

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Quantitative assessment of rat bone regeneration using complex master-slave optical coherence tomography

Cited by 21 publications

References 37 publications

Photobiomodulation Therapy (PBMT) Applied in Bone Reconstructive Surgery Using Bovine Bone Grafts: A Systematic Review

Photobiomodulation Therapy (PBMT) Applied in Bone Reconstructive Surgery Using Bovine Bone Grafts: A Systematic Review

Osteogenic Potential of Bovine Bone Graft in Combination with Laser Photobiomodulation: An Ex Vivo Demonstrative Study in Wistar Rats by Cross-Linked Studies Based on Synchrotron Microtomography and Histology

A combination of imaging techniques for dental medicine: from X-rays radiography and 3D CBCT to OCT

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