1999
DOI: 10.1002/(sici)1098-2280(1999)34:2/3<216::aid-em22>3.0.co;2-3
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Quantitative correlation between radiation-induced mutagenesis in endogenous genes and transgenes of mouse spermatogonial stem cells

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Cited by 11 publications
(1 citation statement)
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“…As with the in vitro assay results, the mutagenic potential of hydroxyurea is not supported by these rodent studies. While Martus and colleagues 55 reported increased mutant plaques in an early version of the transgenic mouse mutation assay, these results must be qualified. First, the exposure regimen is not considered appropriate based on current OECD Test Guidelines.…”
Section: Hydroxyurea Genotoxicity: Preclinical In Vivo Modelsmentioning
confidence: 99%
“…As with the in vitro assay results, the mutagenic potential of hydroxyurea is not supported by these rodent studies. While Martus and colleagues 55 reported increased mutant plaques in an early version of the transgenic mouse mutation assay, these results must be qualified. First, the exposure regimen is not considered appropriate based on current OECD Test Guidelines.…”
Section: Hydroxyurea Genotoxicity: Preclinical In Vivo Modelsmentioning
confidence: 99%