Quantitative Cytotoxicity, Cellular Uptake and Radioprotection Effect of Cerium Oxide Nanoparticles in MRC-5 Normal Cells and MCF-7 Cancerous Cells

Goushbolagh, Nouraddin Abdi; Farhood, Bagher; Astani, Akram; Nikfarjam, Abolfazl; Kalantari, Minoo; Zare, Mohammad Hosein

doi:10.1007/s12668-018-0538-z

Cited by 30 publications

(24 citation statements)

References 32 publications

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“…The main reason of these observations is ability of CONPs in scavenging of free radicals [29,30]. Our experiment is in line with previous results [31,32]. Tarnuzzer et al evaluated radioprotective effect of CONPs on CRL8798, an immortalized normal breast epithelial cell line, and MCF-7 at a 10 Gy radiation dose value.…”

Section: Radioprotective Effect Of Cerium Oxide Nanoparticlessupporting

confidence: 90%

“…On the other hand, the results (Figures 7, 8 , 9, 10, 11 and 12) show that presence of CONPs cannot lead to radioprotective effects in cancerous cell line which it can be due to the high rate of proliferation of the cancer cells compared to the normal cells. In the other words, it can be pointed out that CONPs have selective radioprotection effects [31,35].…”

Section: Radioprotective Effect Of Cerium Oxide Nanoparticlesmentioning

confidence: 99%

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Estimation of radiation dose-reduction factor for cerium oxide nanoparticles in MRC-5 human lung fibroblastic cells and MCF-7 breast-cancer cells

Goushbolagh

Firouzjah

Gorji

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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In the current study, radiation dose-reduction factor (DRF) of nanoceria or cerium oxide nanoparticles (CONPs) in MRC-5 Human Lung Fibroblastic Cells and MCF-7 Breast-Cancer Cells was estimated. Characterization of CONPs was determined using scanner electron microscope (SEM), energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM) and spectrophotometer. Then, six plans were designed with different radiation dose values on planning target value. The obtained MRC-5 and MCF-7 cells were treated with non-toxic concentrations of CONPs and then exposed. Finally, cell viability (%) of the cell lines was determined using MTT assay. The findings showed that CONPs have no significant radioprotective effect against 10 cGy radiation dose value. Nevertheless, 70 lM CONPs resulted in a significant radioprotection against 100, 200, 300, 400 and 500 cGy radiation dose values compared with the control group in MRC-5 cells. For all radiation dose values, mean cell viability (%) of MCF-7 had not increased significantly at the presence of nanoceria compared with control group. According to the findings, it was revealed that the use of CONPs have a significant radioprotective effect on normal lung cells, while they do not provide any protection for MCF-7 cancer cells. These properties can help to increase therapeutic ratio of radiotherapy.

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Section: Radioprotective Effect Of Cerium Oxide Nanoparticlessupporting

confidence: 90%

Section: Radioprotective Effect Of Cerium Oxide Nanoparticlesmentioning

confidence: 99%

Estimation of radiation dose-reduction factor for cerium oxide nanoparticles in MRC-5 human lung fibroblastic cells and MCF-7 breast-cancer cells

Goushbolagh

Firouzjah

Gorji

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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“…Their results revealed that there are no significant differences in the mean cell viability (%) of MCNTs at concentrations up to 50 lg/mL compared to the vehicle group [37]. Nanoparticle distribution plan, cell lines, and cell viability assay can be the cause of cytotoxicity fluctuation [6,38,39].…”

Section: Cytotoxicity Measurementsmentioning

confidence: 99%

“…According to a recent report, there would be an estimation of 18.1 million new cancer cases (other than nonmelanoma skin cancer) and 9.6 million cancer deaths (other than nonmelanoma skin cancer) in 2018 [3]. There are various modalities for the treatment of cancerous tumors such as surgery, radiotherapy, chemotherapy, cryotherapy, and ultrasound with high intensity [4][5][6]. However, most of these therapeutic modalities are relatively effective, and they may return and invasive.…”

Section: Introductionmentioning

confidence: 99%

“…In this in vitro study, MWCNTs-COOH were used as photosensitizer agents for increasing the efficiency of PTT. The main characteristic of current study is using the carboxylate functional group in MWCNTs; as it contributes to optimal biodispersity [24] in which the optimization of dispersity condition can increase the cellular uptake and finally, biological desirable results [6]. Furthermore, it was tried to achieve optimal results at low doses of MWCNTs-COOH and short laser exposure times in PTT.…”

Section: Introductionmentioning

confidence: 99%

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Photosensitizer effects of MWCNTs-COOH particles on CT26 fibroblastic cells exposed to laser irradiation

Goushbolagh

Keshavarz

Zare

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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In the current study, photosensitizer effect of carboxylate multiwalled carbon nanotubes (MWCNTs-COOH) on CT26 fibroblastic cells following near infrared (NIR) irradiation was quantized in photothermal therapy (PTT). Moreover, it was tried to achieve optimal dose of MWCNTs-COOH and laser exposure time. Characterizations of MWCNTs-COOH were scrutinized using scanner electron microscope (SEM), spectrophotometer, and particle size analyzer. The seeded CT26 cells were treated with nontoxic concentrations of MWCNTs-COOH and then irradiated. Finally, viability (%) of the CT26 cells was determined using MTT assay. The findings revealed that 10, 50, and 80 lg/mL of MWCNTs-COOH have remarkable photosensitizer effects on CT26 cancerous cell lines against NIR irradiation (2.5 W/cm 2). It was shown that using the 80 lg/mL concentration of MWCNTs-COOH against 60, 120, 180, 240, and 300 s of NIR irradiation and also, 10 and 50 lg/mL concentration of MWCNTs-COOH against 180, 240, and 300 s of NIR irradiation can lead to significant decrease in mean cell viability (%) by more than 50%. According to the obtained data, it seems that using the PPT with MWCNTs-COOH, as adjunct therapy in CT26 fibroblastic cells, can help to increase therapeutic ratio of main modalities of cancer treatment such as radiotherapy, chemotherapy, and surgery.

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Rational Design of Nanomaterials for Various Radiation‐Induced Diseases Prevention and Treatment

Xie

Zhao

Wang

et al. 2021

Adv Healthcare Materials

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Radiation treatments often unfavorably damage neighboring healthy organs and cause a series of radiation sequelae, such as radiation‐induced hematopoietic system diseases, radiation‐induced gastrointestinal diseases, radiation‐induced lung diseases, and radiation‐induced skin diseases. Recently, emerging nanomaterials have exhibited good superiority for these radiation‐induced disease treatments. Given this background, the rational design principle of nanomaterials, which helps to optimize the therapeutic efficiency, has been an increasing need. Consequently, it is of great significance to perform a systematic summarization of the advances in this field, which can trigger the development of new high‐performance nanoradioprotectors with drug efficiency maximization. Herein, this review highlights the advances and perspectives in the rational design of nanomaterials for preventing and treating various common radiation‐induced diseases. Furthermore, the sources, clinical symptoms, and pathogenesis/injury mechanisms of these radiation‐induced diseases will also be introduced. Furthermore, current challenges and directions for future efforts in this field are also discussed.

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Quantitative Cytotoxicity, Cellular Uptake and Radioprotection Effect of Cerium Oxide Nanoparticles in MRC-5 Normal Cells and MCF-7 Cancerous Cells

Cited by 30 publications

References 32 publications

Estimation of radiation dose-reduction factor for cerium oxide nanoparticles in MRC-5 human lung fibroblastic cells and MCF-7 breast-cancer cells

Estimation of radiation dose-reduction factor for cerium oxide nanoparticles in MRC-5 human lung fibroblastic cells and MCF-7 breast-cancer cells

Photosensitizer effects of MWCNTs-COOH particles on CT26 fibroblastic cells exposed to laser irradiation

Rational Design of Nanomaterials for Various Radiation‐Induced Diseases Prevention and Treatment

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