Quantitative detection of glaucomatous damage at the posterior pole by retinal thickness mapping

Zeimer, Ran; Asrani, Sanjay; Zou, Shazhou; Quigley, Harry A.; Jampel, Henry D.

doi:10.1016/s0161-6420(98)92743-9

Cited by 257 publications

(200 citation statements)

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“…Zeimer showed that the Retinal Thickness Analyzer (RTA, Taila Technology Ltd., Neve-Ilan, Israel) mapping of the posterior pole may detect retinal thickness loss in glaucoma patients [12]. Tanito et al [22] reported that perifoveal average thickness values in PG eyes were significantly less than in normal control eyes using RTA.…”

Section: Discussionmentioning

confidence: 99%

“…Macular thickness evaluation is gaining increasing attention after Zeimer hypothesized that quantitative detection of glaucomatous damage at the posterior pole by retinal thickness mapping may provide a method for detection and monitoring early glaucomatous damage [12]. The introduction of spectral domain optical coherence tomography (SD-OCT) allows us to measure the ganglion cell complex (GCC, the combination of retinal nerve fiber, retinal ganglion cell and inner plexiform layers) covering the central macula.…”

Section: Introductionmentioning

confidence: 99%

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Structural and functional assessment by hemispheric asymmetry testing of the macular region in preperimetric glaucoma

et al. 2013

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Purpose To investigate structural measurements of the macular area in preperimetric glaucoma (PG) patients using spectral domain optical coherence tomography with two functional measurements [10-2 Humphrey visual field (HFA) and 10-2 Microperimeter-1 (MP-1)] and by macular symmetry testing. Methods Fifteen eyes of 15 PG subjects with a retinal nerve fiber layer defect in the inferior hemisphere and 15 eyes of 15 normal control subjects were enrolled. Macular symmetry testing was performed between the superior and inferior zones by comparing zone thickness in each hemisphere. Perimetric sensitivity asymmetry was calculated with two functional measurements. Structure-function relationships between macular symmetry testing and the mean retinal sensitivity of the corresponding hemifield or perimetric sensitivity asymmetry were calculated using Spearman's rank correlation and linear regression. Results Macular zone thickness in the abnormal hemispheres was significantly less than that in normal hemispheres in PG eyes and the corresponding hemispheres in control eyes (P \ 0.001). Macular symmetry testing was significantly lower in PG eyes compared to control eyes (P \ 0.001). HFA (10-2) and MP-1 (10-2) correlated significantly (rs = 0.81, P \ 0.0001). Macular symmetry testing values were significantly correlated with perimetric sensitivity and perimetric sensitivity asymmetry with two functional measurements (rs = 0.61, P = 0.02; HFA and rs = 0.68, P = 0.006; MP-1). Conclusions Our results suggest that macular asymmetry analysis can reveal the structure-functional relationship in PG eyes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structural and functional assessment by hemispheric asymmetry testing of the macular region in preperimetric glaucoma

et al. 2013

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“…The ganglion cells and RNFL are reported to contribute to approximately 35% of the macular thickness. 2 Accordingly, if ganglion cell loss is the major cause for the macular thinning, macular thickness remains at least about 65% of controls. This notion was supported by the present finding that the mean macular thickness in eyes with optic atrophy exceeded 60% of that in unaffected eyes at each area.…”

Section: Discussionmentioning

confidence: 99%

Macular thickness reduction in eyes with unilateral optic atrophy detected with optical coherence tomography

Kusuhara

Nakamura

Nagai-Kusuhara

et al. 2005

Eye

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Aims To assess the changes in macular and peripapillary retinal nerve fibre layer (RNFL) thickness in eyes with unilateral optic atrophy and to evaluate the relationship between retinal thickness and visual function. Methods Enrolled were 22 patients with unilateral optic atrophy. Macular thickness at the divided nine areas and peripapillary RNFL thickness in quadrantic sections were measured by optical coherence tomography. Thickness values in the affected eyes were compared with those in the contralateral unaffected eyes. The correlation of foveal thickness with best-corrected visual acuity (BCVA) was evaluated. The correlation between retinal thickness and the remaining visual field area circumscribed with I-4-e isopter in superior and inferior hemifield was assessed.Results Macular thinning was observed in all areas (Po0.001 in each area) other than the fovea (P ¼ 0.068). Peripapillary RNFL thickness decreased in all quadrantic sections (Po0.001 in each section). The affected to unaffected eye ratio of retinal thickness was more than 0.6 in each area. BCVA did not correlate with foveal thickness (correlation coefficient ¼ 0.094, P ¼ 0.668). Although not statistically significant (P ¼ 0.281, superior hemifield; P ¼ 0.053, inferior hemifield), there was a tendency that eyes with severe visual field loss show more marked retinal thinning. Conclusions Macular thinning with the preserved foveal thickness is a hallmark of eyes with optic atrophy. Together with no correlation between foveal thickness and BCVA, this finding would help in differential diagnosis of macular and optic nerve diseases.

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“…Loss of macular thickness in glaucoma can be attributed mainly to RGC and NFL atrophy. 4,5 It may be useful, therefore, to assess macular thickness, because Zeimer et al 4,6 hypothesized that macular RGC loss may result in significant retinal thinning. They proposed quantitative detection of glaucomatous damage at the posterior pole by retinal thickness mapping.…”

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Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes

et al. 2003

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Purpose-To evaluate the hypothesis that macular thickness correlates with the diagnosis of glaucoma.Design-Cross-sectional study.Participants-We studied 367 subjects (534 eyes), including 166 eyes of 109 normal subjects, 83 eyes of 58 glaucoma suspects, 196 eyes of 132 early glaucoma patients, and 89 eyes of 68 advanced glaucoma patients.Methods-We used optical coherence tomography (OCT) to measure macular and nerve fiber layer (NFL) thickness and to analyze their correlation with each other and with glaucoma status. We used both the commercial and prototype OCT units and evaluated correspondence between measurements performed on the same eyes on the same days. Main Outcome Measure-Macular and NFL thickness as measured by OCT.Results-All NFL parameters both in prototype and commercial OCT units were statistically significantly different comparing normal subjects and either early or advanced glaucoma (P < 0.001). Inner ring, outer ring, and mean macular thickness both in prototype and commercial OCT devices were found to be significantly different between normal subjects and advanced glaucomatous eyes (P < 0.001). The outer ring was the only macular parameter that could significantly differentiate between normal and early glaucoma with either the prototype or commercial OCT unit (P = 0.003, P = 0.008, respectively). The area under the receiver operator characteristic (AROC) curves comparing mean NFL thickness between normal and advanced glaucomatous eyes was 1.00 for both the prototype and commercial OCT devices for eyes scanned on both machines on the same day. The Reprint requests to Joel S. Schuman, MD, New England Eye Center, Tufts University School of Medicine, 750 Washington St, Box 450, Boston, MA 02111. Joel S. Schuman and Gadi Wollstein shared equal parts in the preparation of the manuscript.Presented in part at the American Academy of Ophthalmology (AAO), Orlando, Florida, 1999. NIH Public Access Author ManuscriptOphthalmology. Author manuscript; available in PMC 2007 August 15. Published in final edited form as:Ophthalmology. 2003 January ; 110(1): 177-189. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptAROC comparing mean macular thickness in normal and advanced glaucomatous eyes scanned on both machines on the same day was 0.88 for the prototype OCT device and 0.80 for the commercial OCT.Conclusions-Both macular and NFL thickness as measured by OCT showed statistically significant correlations with glaucoma, although NFL thickness showed a stronger association than macular thickness. There was good correspondence between findings using both the prototype and commercial OCT units. Macular and NFL thickness measurements made with OCT may have usefulness in the clinical assessment of glaucoma.Glaucoma is a process in which a loss of retinal ganglion cells (RGCs) results in characteristic optic nerve and visual field abnormalities. Detection of glaucomatous damage is typically through observation of the optic nerve head and retinal nerve fiber layer (NFL) and measurem...

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Quantitative detection of glaucomatous damage at the posterior pole by retinal thickness mapping

Cited by 257 publications

References 16 publications

Structural and functional assessment by hemispheric asymmetry testing of the macular region in preperimetric glaucoma

Structural and functional assessment by hemispheric asymmetry testing of the macular region in preperimetric glaucoma

Macular thickness reduction in eyes with unilateral optic atrophy detected with optical coherence tomography

Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes

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