Quantitative determination of potent α-glucosidase inhibitors, salacinol and kotalanol, in Salacia species using liquid chromatography–mass spectrometry

Muraoka, Osamu; Morikawa, Toshio; Miyake, Sohachiro; Akaki, Junji; Ninomiya, Kiyofumi; Yoshikawa, Masayuki

doi:10.1016/j.jpba.2010.02.025

Cited by 43 publications

(46 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…α-glucosidase inhibition was linked to the total phenolic content. Other plants with the α-glucosidase inhibitor effect are Macaranga tanarius (Puteri and Kawabata, 2010), Salacia oblonga, Salacia chinensis (Giron et al, 2009;Muraoka et al, 2010), Eleutherine americana (Ieyama et al, 2011), Aquilaria sinensis (Feng et al, 2011), and Panax japonicus (Chan et al, 2010).…”

Section: A Plant Extracts With Antidiabetic Actionmentioning

confidence: 99%

“…Sugar-like structures, more precisely thiosugars such as kotalanol (Xie et al, 2011a), salacinol (Muraoka et al, 2010), neoponkoranol, neosalaprinol (Xie et al, 2011b), and de-O-sulphatedkotalanol , also have α-glucosidase inhibitory effects that are sometimes comparable to that of the prescription drugs acarbose and voglibose. Similar effects are also reported for the alkaloids nummularine-R, nummularin-C, and hemsine-A (Choudhary et al, 2011); some polyacethylenes and saponins (Chan et al, 2010); polyphenolic compounds such as iriflophenone 2-O-α-L-rhamnopyranoside, iriflophenone 3-C-β-D-glucoside, iriflophenone-3,5-C-β-D-diglucopyranoside (Feng et al, 2011), eleutherinoside , and eleuthoside (Ieyama et al, 2011); and bromophenols such as 2,4,6-tribromophenol and 2,4-dibromophenol (Kim et al, 2011).…”

Section: B Natural Plant Biomolecules With Antidiabetic Actionmentioning

confidence: 99%

See 1 more Smart Citation

Plants and Natural Compounds with Antidiabetic Action

Coman

Rugină

Socaciu

2012

Not Bot Hort Agrobot Cluj

132

View full text Add to dashboard Cite

Diabetes has become the most common metabolic disease worldwide. In particular, type 2 diabetes is the most commonly encountered type of diabetes, which is characterised by the inability of the organism to respond to normal levels of circulating insulin, also called insulin resistance. Current antidiabetic therapy is based on synthetic drugs that very often have side effects. For this reason, there is a continuous need to develop new and better pharmaceuticals as alternatives for the management and treatment of the disease. Natural hypoglycaemic compounds may be attractive alternatives to synthetic drugs or reinforcements to currently used treatments. Their huge advantage is that they can be ingested in everyday diet. Recently, more attention is being paid to the study of natural products as potential antidiabetics. This mini review of the current literature is structured into three main sections focused on: (a) plant extracts, (b) plant biomolecules, and (c) other natural molecules that have been used for their antidiabetic effects. Potential molecular mechanisms of action are also discussed.

show abstract

Section: A Plant Extracts With Antidiabetic Actionmentioning

confidence: 99%

Section: B Natural Plant Biomolecules With Antidiabetic Actionmentioning

confidence: 99%

Plants and Natural Compounds with Antidiabetic Action

Coman

Rugină

Socaciu

2012

Not Bot Hort Agrobot Cluj

132

View full text Add to dashboard Cite

show abstract

“…Flammang et al (2006Flammang et al ( , 2007 demonstrated that the root extract of S. oblonga did not present mutagenicity using the Ames test in strains of Salmonella typhimurium and a test of chromosomal aberrations in cultured rat peripheral blood lymphocytes (in vivo study). Previous studies have demonstrated that various extracts of Salacia species (S. oblonga, S. chinensis, and S. prioidis) show potent α-glucosidase-inhibitory activity, which may be used as adjunctive therapy in the treatment of individuals with diabetes mellitus (Matsuda et al, 2002;Muraoka et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Phytochemical studies with several species of the genus Salacia have demonstrated the presence of phenolic compounds, quinone-methide triterpenes, friedelane triterpenes, and flavonoids, which show antioxidant and free radical scavenging activities (Morikawa et al, 2003;Carvalho et al, 2005;Muraoka et al, 2010;Somwong et al, 2011). Caramori et al (2004) demonstrated that the seed extract of S. crassifolia contains a considerable amount of polyphenols.…”

Section: Discussionmentioning

confidence: 99%

Assessment of genotoxic, cytotoxic, and protective effects of Salacia crassifolia (Mart. Ex. Schult.) G. Don. stem bark fractions in mice

Carneiro

Silva²,

Menezes³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Salacia crassifolia (Mart. Ex. Schult.) G. Don., popularly known in Brazil as "bacupari", "cascudo", and "saputá", is a shrub of the Celastraceae family that is unique to the Brazilian Cerrado region. In folk medicine, this plant has been mainly used to treat skin cancer and gastric ulcers. In the present study, the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic effects of S. crassifolia stem bark fractions (hexane, ethyl acetate, and hydroalcoholic extracts) were evaluated using the mouse bone marrow micronucleus test. Our results showed that none of the S. crassifolia fractions led to a significant increase in the frequency of micronucleated polychromatic erythrocytes (MNPCE) (P > 0.05), suggesting the absence of genotoxicity. In the antigenotoxicity assessment, a significant decrease in the MNPCE frequency was observed in all fractions of this plant (P < 0.05), demonstrating its protective action against genotoxicity induced by mitomycin C (MMC), which was used as the positive control. Only the hexane fraction of S. crassifolia significantly decreased the poly-and normochromatic erythrocyte ratio (PCE/NCE) in all doses tested (P < 0.05), demonstrating its cytotoxic activity. In association with MMC, both ethyl acetate and hydroalcoholic fractions significantly increased the PCE/NCE ratio in almost all doses tested (P < 0.05), demonstrating the protective action of S. crassifolia against the cytotoxic effect of the positive control. In contrast, the hexane fraction presented a significant decrease in the PCE/NCE ratio in all treatments (P < 0.05), demonstrating an increase in this plant's cytotoxicity in mouse bone marrow cells.

show abstract

“…Accordingly, C. mukul resin was extracted using petroleum ether, 16 S. reticulata root using water, 17 bark of T. arjuna 18 and rhizome of C. longa using methanol. 19 Approximately, 20 g of each powder was extracted with 150 mL of respective solvent using a magnetic stirrer for 72 h; changing solvent every 24 h. Each time the supernatants obtained by centrifugation were collected.…”

Section: Hptlc Fingerprintingmentioning

confidence: 99%

Component Authentication and Standardisation of an Anti-atherosclerotic Herbal Formulation-GSTC3

Manalil¹,

Suseela²,

Ramavarma³

et al. 2015

Phcog J

View full text Add to dashboard Cite

Context: Polyherbal drugs in traditional medicine have been time-tested for treatment of a wide variety of chronic ailments. Aims: To determine constituent components in an in-house designed polyherbal formulation GSTC3 and evaluation of consistency in preparation. Settings and Design: In this study, a hypolipidemic formulation was created using well known plant extracts such as Commiphora mukul (Hook. ex Stocks.) Eng. (Burseraceae), Salacia reticulata Wight (Celastraceae), Terminalia arjuna (Roxb.) Wight and Arn (Combretaceae) and Curcuma longa Linn (Zingiberaceae). Methods and Material:The authentication of individual plant powders was performed using techniques such as powder microscopy and characterised according to Ayurvedic pharmacopeia of India. Phytochemical screening, HPTLC analysis and physicochemical parameters were also determined. Results:The powder microscopic analysis of the individual components served as an authentication for source of plants used. Phytochemical screening ascertained that active classes of compounds reported in the individual extracts such as steroids, terpenoids and polyphenols came into the formulation. Finally, HPTLC analysis of three different batches of GSTC3 ensured stability and integrity in batch to batch preparations. Conclusion: Experimental studies have revealed the antioxidant, antiinflammatory, anti-lipidemic and anti-thrombotic efficacy of GSTC3. This standardisation procedure is essential for further development of GSTC3 into an efficient anti-atherosclerotic drug candidate.Key words: HPTLC, Pharmacognosy, Polyherbal formulation, Powder microscopy, Phytochemical screening. SUMMARY• GSTC is an anti-atherosclerotic polyherbal formulation developed from four individual medicinal plants.• Powder microscopic analysis of the individual components of GSTC3 served as an authentication of source plant.• Phytochemical screening ascertained the presence of steroids, terpenoids and polyphenols in the formulation.• HPTLC analysis of three different batches of GSTC3 ensured stability and integrity among batch to batch preparations.• Physicochemical analysis showed the feasibility of GSTC3 in its further development as an efficient anti-atherosclerotic drug candidate.

show abstract

Quantitative determination of potent α-glucosidase inhibitors, salacinol and kotalanol, in Salacia species using liquid chromatography–mass spectrometry

Cited by 43 publications

References 13 publications

Plants and Natural Compounds with Antidiabetic Action

Plants and Natural Compounds with Antidiabetic Action

Assessment of genotoxic, cytotoxic, and protective effects of Salacia crassifolia (Mart. Ex. Schult.) G. Don. stem bark fractions in mice

Component Authentication and Standardisation of an Anti-atherosclerotic Herbal Formulation-GSTC3

Contact Info

Product

Resources

About