Quantitative determination of the antimalarials artemether and lumefantrine in biological samples: A review

Resende, Luisa Avelar; Silva, Pedro Henrique Reis da; Fernandes, Christian

doi:10.1016/j.jpba.2018.12.021

Cited by 7 publications

(3 citation statements)

References 44 publications

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“…First, the extraction method was optimized. There are various possible sample extraction methods for DBS [ 25 – 27 ]. We tested three representative methods for DBS extraction, namely, protein precipitation, organic extraction, and liquid–liquid extraction.…”

Section: Resultsmentioning

confidence: 99%

Simultaneous determination of cardiovascular drugs in dried blood spot by liquid chromatography-tandem mass spectrometry

Kim

Park

Long

et al. 2019

Journal of Food and Drug Analysis

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A dried blood spot (DBS) sampling method was exploited to extract cardiovascular drugs using a small volume of whole blood of human and rodent. Thereafter, an analytical method using liquid chromatography with tandem mass spectrometry (LC-MS/MS) was developed and validated for the determination of 12 cardiovascular drugs. A 6 mm internal diameter disc containing 10 μL of blood was punched from a specifically designed card and analyzed by LC-MS/MS using a gradient elution method with a total run time of 16 min. For sample separation, a universal octadecyl-silica column was used with a flow rate of 0.2 mL/ min. The developed method was validated in terms of linearity, accuracy, and precision, which showed satisfactory results. In addition, the matrix effects were closely investigated to confirm the extraction efficiency. Additionally, the stability was tested by storing DBSs at room temperature; the results showed that these drugs were stable for at least 30 days. Accordingly, the proposed LC-MS/MS method is capable to analyze several cardiovascular drugs in a single analysis. It can be applied to therapeutic drug monitoring in patients as well as in the in vivo settings.

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Section: Resultsmentioning

confidence: 99%

Simultaneous determination of cardiovascular drugs in dried blood spot by liquid chromatography-tandem mass spectrometry

Kim

Park

Long

et al. 2019

Journal of Food and Drug Analysis

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“…When it comes to the metabolism of artemether, CYP3A4 and CYP2B6 are responsible for immediate hepatic metabolism [38,63,64]. Lumefantrine, however, is absorbed more slowly and is largely metabolized by CYP3A4 to its active metabolite [63,64].…”

Section: Metabolism and Cyp Enzyme Maturationmentioning

confidence: 99%

Estimation of Pediatric Dosage of Antimalarial Drugs, Using Pharmacokinetic and Physiological Approach

et al. 2023

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Most of the individuals who die of malaria in sub–Saharan Africa are children. It is, therefore, important for this age group to have access to the right treatment and correct dose. Artemether—lumefantrine is one of the fixed dose combination therapies that was approved by the World Health Organization to treat malaria. However, the current recommended dose has been reported to cause underexposure or overexposure in some children. The aim of this article was, therefore, to estimate the doses that can mimic adult exposure. The availability of more and reliable pharmacokinetic data is essential to accurately estimate appropriate dosage regimens. The doses in this study were estimated using the physiological information from children and some pharmacokinetic data from adults due to the lack of pediatric pharmacokinetic data in the literature. Depending on the approach that was used to calculate the dose, the results showed that some children were underexposed, and others were overexposed. This can lead to treatment failure, toxicity, and even death. Therefore, when designing a dosage regimen, it is important to know and include the distinctions in physiology at various phases of development that influence the pharmacokinetics of various drugs in order to estimate the dose in young children. The physiology at each time point during the growth of a child may influence how the drug is absorbed, gets distributed, metabolized, and eliminated. From the results, there is a very clear need to conduct a clinical study to further verify if the suggested (i.e., 0.34 mg/kg for artemether and 6 mg/kg for lumefantrine) doses could be clinically efficacious.

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“…The usual xed-dose combination containing 20 mg artemether and 120 mg of lumefantrine per tablet is manufactured by Novartis Pharmaceuticals and sold under the brand name Coartem. 6 It is recommended for treating Plasmodium falciparum induced malaria. Lumefantrine has extensive conjugation and high molar absorptivity.…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted polymeric coatings for sensitive and selective gravimetric detection of artemether

et al. 2020

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Quantitative determination of the antimalarials artemether and lumefantrine in biological samples: A review

Cited by 7 publications

References 44 publications

Simultaneous determination of cardiovascular drugs in dried blood spot by liquid chromatography-tandem mass spectrometry

Simultaneous determination of cardiovascular drugs in dried blood spot by liquid chromatography-tandem mass spectrometry

Estimation of Pediatric Dosage of Antimalarial Drugs, Using Pharmacokinetic and Physiological Approach

Molecularly imprinted polymeric coatings for sensitive and selective gravimetric detection of artemether

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