Quantitative deviating effects of maple syrup extract supplementation on the hepatic gene expression of mice fed a high‐fat diet

Kamei, Asuka; Watanabe, Yuki; Shinozaki, Fumika; Yasuoka, Akihito; Shimada, Kosuke; Kondo, K.; Ishijima, Tomoko; Toyoda, Tsudoi; Arai, Soichi; Kondo, Takashi; Abe, Keiko

doi:10.1002/mnfr.201600477

Cited by 9 publications

(7 citation statements)

References 32 publications

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“…15, 16 Maple syrup contains a wide variety of phenolic constituents 17–19 and in our group’s ongoing research on this natural product, 16, 18–21 we have developed a phenolic-enriched maple syrup extract (MSX) for nutraceutical applications which is well-tolerated and non-toxic to rats (at doses of up to 1000 mg/kg/day). 20 Phenolic-enriched extracts of maple syrup have been reported to show antioxidant 18 , anti-diabetic, 20–22 anticancer, 23 anti-inflammatory 24, 25 , and neuroprotective 26, 27 properties in vitro. More recently, our group has also reported on the neuroprotective effects of MSX on murine microglia BV-2 cells, human neuronal SH-SY5Y cells, and against neurotoxicity in Caenorhabditis elegans in vivo.…”

Section: Introductionmentioning

confidence: 99%

Anti-glycation and anti-oxidative effects of a phenolic-enriched maple syrup extract and its protective effects on normal human colon cells

Liu

Wei

et al. 2017

Food Funct.

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Oxidative stress and free radical generation accelerate the formation of advanced glycation endproducts (AGEs) which are linked to several chronic diseases. Published data suggest that phenolic-rich plant foods, show promise as natural anti-AGEs agents due to their anti-oxidation capacities. A phenolic-enriched maple syrup extract (MSX) has previously been reported to show anti-inflammatory and neuroprotective effects but its anti-AGE effects remain unknown. Therefore, herein, we investigated the anti-glycation and anti-oxidation effects of MSX using biochemical and biophysical methods. MSX (500 μg/mL) reduced the formation of AGEs by 40% in the bovine serum albumin (BSA)-fructose assay and by 30% in the BSA-methylglyoxal (MGO) assay. MSX also inhibited the formation of crosslinks typically seen in the late stage of glycation. Circular dichroism and differential scanning calorimeter analyses demonstrated that MSX maintained the structure of BSA during glycation. In the anti-oxidant assays, MSX (61.7 μg/mL) scavenged 50% of free radicals (DPPH assay) and reduced free radical generation by 20% during the glycation process (electron paramagnetic resonance time scan). In addition, the intracellular levels of hydrogen peroxide induced reactive oxygen species were reduced by 27-58% with MSX (50-200 μg/mL) in normal/non-tumorigenic human colon CCD-18Co cells. Moreover, in AGEs and MGO challenged CCD-18Co cells, higher cellular viabilities and rapid extracellular signal–regulated kinase (ERK) phosphorylation were observed in MSX treated cells, indicating its protective effects against AGEs-induced cytotoxicity. Overall, this study supports the biological effects of MSX, and warrants further investigation of its potential as a dietary agent against diseases mediated by oxidative stress and inflammation.

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Section: Introductionmentioning

confidence: 99%

Anti-glycation and anti-oxidative effects of a phenolic-enriched maple syrup extract and its protective effects on normal human colon cells

Liu

Wei

et al. 2017

Food Funct.

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“…The expression of several inflammatory proteins, including Alzheimer’s disease risk-associated proteins, was reduced by maple syrup extract. The impact that maple syrup extract had on hepatic gene expression in mice on a high-fat diet has been reported by Kamei et al [ 68 ] and Kamei et al [ 72 ]. According to changes in the expression of the genes associated with lipid metabolism and immune response, maple syrup extract can help to attenuate hepatic inflammation in mice.…”

Section: Nutritional Profile and Health Impactsmentioning

confidence: 80%

Maple Syrup: Chemical Analysis and Nutritional Profile, Health Impacts, Safety and Quality Control, and Food Industry Applications

Saraiva

Carrascosa

Ramos

et al. 2022

IJERPH

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Maple syrup is a delicacy prepared by boiling the sap taken from numerous Acer species, primarily sugar maple trees. Compared to other natural sweeteners, maple syrup is believed to be preferable to refined sugar for its high concentration of phenolic compounds and mineral content. The presence of organic acids (malic acid), amino acids and relevant amounts of minerals, such as potassium, calcium, zinc and manganese, make maple syrup unique. Given the growing demand for naturally derived sweeteners over the past decade, this review paper deals with and discusses in detail the most important aspects of chemical maple syrup analyses, with a particular emphasis on the advantages and disadvantages of the different analytical approaches. A successful utilization on the application of maple syrup in the food industry, will rely on a better understanding of its safety, quality control, nutritional profile, and health impacts, including its sustainability issues.

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“…Polyphenols are also preponderant components in maple syrup composition [ 34 , 35 ]. The role of polyphenols in the nutritional properties of maple syrup has therefore been suggested and intensively investigated.…”

Section: Nutritional and Functional Properties Of Maple Syrupmentioning

confidence: 99%

Nutritional, pharmacological, and sensory properties of maple syrup: A comprehensive review

Mohammed,

Sibley,

Abdulwali

et al. 2023

Heliyon

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Quantitative deviating effects of maple syrup extract supplementation on the hepatic gene expression of mice fed a high‐fat diet

Abstract: Our study suggested that the effects of MSXH ingestion showed (i) dose-dependent pattern involved in energy metabolisms and (ii) reversely pattern involved in stress responses.

Cited by 9 publications

References 32 publications

Anti-glycation and anti-oxidative effects of a phenolic-enriched maple syrup extract and its protective effects on normal human colon cells

Anti-glycation and anti-oxidative effects of a phenolic-enriched maple syrup extract and its protective effects on normal human colon cells

Maple Syrup: Chemical Analysis and Nutritional Profile, Health Impacts, Safety and Quality Control, and Food Industry Applications

Nutritional, pharmacological, and sensory properties of maple syrup: A comprehensive review

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