Quantitative EEG in patients with presenile and senile dementia of the Alzheimer type

Miyauchi, Takashi; Hagimoto, Hiroshi; Ishii, Masato; Endo, Seiji; Tanaka, K; Kajiwara, S.; Endo, Keiko; Kajiwara, A; Kosaka, Kenji

doi:10.1111/j.1600-0404.1994.tb01633.x

Cited by 37 publications

(11 citation statements)

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“…In the present casuistic, the finding of an increase in the theta power and to a lesser degree in the delta band in the AD group is in agreement with the literature 4,21 . In this survey the alterations in coherence were limited to the alpha and beta bands and the frontal and temporal regions (F3-F4 and F7-F8), similarly to that described in the literature [5][6][7] .…”

Section: Discussionsupporting

confidence: 93%

“…This analysis reflects functional interactions between neural networks represented in the cortex 3 . In comparison with normal controls, there is increased activity in the theta band in subjects with Alzheimer's disease (AD), which is accompanied by an increase in delta activity and decreases in the alpha and beta bands 4 . In studies on coherence in AD, the most consistent finding has been a reduction in coherence in the alpha band [5][6][7] .…”

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confidence: 99%

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Alzheimer's disease: relationship between cognitive aspects and power and coherence EEG measures

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Tedrus

Prandi³

et al. 2011

Arq. Neuro-Psiquiatr.

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Objective: To evaluate the relationship between specific cognitive aspects and quantitative EEG measures, in patients with mild or moderate Alzheimer's disease (AD). Method: Thirty-eight AD patients and 31 controls were assessed by CERAD neuropsychological battery (Consortium to Establish a Registry for AD) and the electroencephalogram (EEG). The absolute power and coherences EEG measures were calculated at rest. The correlations between the cognitive variables and the EEG were evaluated. Results: In the AD group there were significant correlations between different coherence EEG measures and Mini-Mental State Examination, verbal fluency, modified Boston naming, word list memory with repetition, word list recall and recognition, and constructional praxis (p<0.01). These correlations were all negative for the delta and theta bands and positive for alpha and beta. There were no correlations between cognitive aspects and absolute EEG power. Conclusion: The coherence EEG measures reflect different forms in the relationship between regions related to various cognitive dysfunctions. Key words: dementia, cognition, Alzheimer's disease, electroencephalography. Doença de Alzheimer: relação entre aspectos cognitivos e medidas de potência e coerência no eletrencefalograma RESUMO Objetivo: Avaliar as relações entre aspectos cognitivos específicos e medidas quantitativas do EEG em pacientes com doença de Alzheimer (DA) leve e moderado. Método: Trinta e oito pacientes com DA e 31 controles foram avaliados com a bateria neuropsicológica CERAD (Consortium to Establish a Registry for AD) e o eletroencefalograma. Foram realizadas medidas de potência absoluta e coerência do EEG, durante repouso, e avaliadas suas relações com variáveis do CERAD. Resultados: No grupo DA houve correlações significativas entre diferentes medidas de coerência e o mini-exame do estado mental, fluência verbal, teste de nomeação de Boston modificado, memória de lista de palavras com repetição, recordação e reconhecimento de lista de palavras e praxia construtiva (p<0,01). Essas correlações foram negativas para as faixas delta e teta e positivas para alfa e beta. Conclusão: As medidas de coerência do EEG em repouso refletem diferentes formas de organização nas relações entre regiões, relacionadas a várias disfunções cognitivas. Palavras-Chave: demência, cognição, doença de Alzheimer, eletroencefalograma. Correspondence

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Alzheimer's disease: relationship between cognitive aspects and power and coherence EEG measures

Fonseca

Tedrus

Prandi³

et al. 2011

Arq. Neuro-Psiquiatr.

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“…In the present casuistry, the finding of an increase in theta power, and to a lesser extent of the delta band, is similar to that reported in the literature [13][14][15] . No significant decreases in the alpha and beta powers were found, probably because the greater part of the patients was in the mild stage of AD.…”

Section: Discussionsupporting

confidence: 80%

“…In studies on AD using analyses of EEG frequencies, an increase in activity of the theta band has been found, and during evolution of the disease, this is associated with an increase in the delta activity and a decrease in the alpha and beta bands 13 . The increase in theta activity and reduction in alpha activity can be accompanied by calculating the theta/alpha index.…”

Section: Discussionmentioning

confidence: 99%

Quantitative electroencephalography power and coherence measurements in the diagnosis of mild and moderate Alzheimer's disease

Fonseca

Tedrus

Prandi

et al. 2011

Arq. Neuro-Psiquiatr.

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Objective: To evaluate the contribution of quantitative electroencephalographic (qEEG) analyses in the diagnosis of Alzheimer's disease (AD). Method: Thirty-five patients from the Neurology Outpatients Clinic of PUC-Campinas, diagnosed with AD according to the NINCDS/ADRDA were evaluated, and compared with a control group consisting of 30 individuals with no cognitive deficit. The procedures consisted of clinical-neurological, cognitive and behavioral analyses and the qEEG (absolute power and coherence). Results: The AD group presented greater absolute power values in the delta and theta bands, greater theta/alpha indices and less frontal alpha and beta coherence. Logistic multiple regression models were constructed and those only showing variations in the qEEG (frontal alpha coherence and left frontal absolute theta power) showed an accuracy classification (72.3%) below that obtained in the mini-mental state examination (93%). Conclusion: The study of coherence and power in the qEEG showed a relatively limited accuracy with respect to its application in routine clinical practice. Key words: dementia, Alzheimer's disease, electroencephalography, EEG, coherence.Medidas de coerência e de potência absoluta no eletrencefalograma quantitativo no diagnóstico da doença de Alzheimer RESUMO Objetivo: Avaliar a contribuição das análises quantitativas do eletroencefalograma (qEEG) no diagnóstico da doença de Alzheimer (DA). Método: Foram avaliados 35 pacientes do ambulatório de Neurologia Clínica da PUC-Campinas, com o diagnóstico de DA segundo o NINCDS/ADRDA e comparados a 30 indivíduos, sem déficit cognitivo, de grupo controle. Os procedimentos foram avaliação clínico-neurológica, cognitiva e comportamental e EEGq (potência absoluta e coerência). Resultados: O grupo DA apresentou maiores potências absolutas nas faixas delta e teta, maiores índices teta/alfa e menor coerência alfa e beta frontal. Foram construídos modelos de regressão múltipla logística e aquele que contou apenas com variáveis do EEGq (coerência alfa frontal e potência absoluta teta frontal esquerda) teve acurácia de classificação (72,3%), inferior à obtida com o mini-exame do estado mental (93%). Conclusão: O estudo de coerência e potência no qEEG tem acurácia relativamente limitada no sentido de aplicação prática clínica rotineira. Palavras-chave: demência, doença de Alzheimer, eletroencefalografia, EEG, coerência, potência absoluta.

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“…Claus et al (1999), mostraram que a análise visual do EEG já pode ser útil no auxílio diagnóstico da DA, sendo indicada em protocolos clínicos para o diagnóstico desta doença. Os achados mais comuns são o alentecimento da atividade elétrica cerebral de base por predomínio dos ritmos delta e teta e a diminuição ou ausência do ritmo alfa (Dierks et al, 1991;Leuchter et al, 1993;Miyauchi et al, 1994;Sandmann et al, 1996;Rodriguez et al, 1999).…”

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Estudo da análise da razão alfa/teta em pacientes com doença de Alzheimer provável

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Quantitative EEG in patients with presenile and senile dementia of the Alzheimer type

Cited by 37 publications

References 35 publications

Alzheimer's disease: relationship between cognitive aspects and power and coherence EEG measures

Alzheimer's disease: relationship between cognitive aspects and power and coherence EEG measures

Quantitative electroencephalography power and coherence measurements in the diagnosis of mild and moderate Alzheimer's disease

Estudo da análise da razão alfa/teta em pacientes com doença de Alzheimer provável

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