Abstract:Peptide dimerization plays an important role in
both natural and artificial supramolecular systems. A major challenge to date is the quantitative heterodimerization
of two peptides without formation of homodimers. Here,
we employ a macrocyclic host to simultaneously encapsulate a canonical aromatic peptide and a non-canonical
perfluorophenylalanine-containing peptide through polar–π
interactions, thus forming an unprecedented new series of
heteropeptide dimers with high binding affinity. This new
peptide heter… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.