Quantitative mapping of T1 and T2* discloses nigral and brainstem pathology in early Parkinson's disease

Baudrexel, Simon; Nürnberger, Lucas; Rüb, Udo; Seifried, Carola; Klein, Johannes; Deller, Thomas; Steinmetz, Helmuth; Deichmann, Ralf; Hilker, Rüdiger

doi:10.1016/j.neuroimage.2010.03.005

Cited by 137 publications

(145 citation statements)

References 62 publications

(81 reference statements)

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“…Examples include magnetization transfer imaging (8), T1 and T2* maps (9), and susceptibility weighted imaging (10). Some are characterized by long imaging times and/or multiple acquisitions that require consistent head position, which could be difficult to translate into clinical settings.…”

Section: Discussionmentioning

confidence: 99%

“…Segmentation of these structures based on a T1w image is difficult, due to the low levels of contrast between the basal ganglia and surrounding structures and the absence of easily visible contours (6). To overcome this problem, a number of approaches have been investigated (7)(8)(9)(10). Among these, a recent study has proposed a modification of the standard MPRAGE sequence parameters to yield a better visualization of GPe and GPi; this was achieved by using a value of inversion time (TI) shorter (409 msec at 3T) than the TI typically employed in the standard MPRAGE (900 msec at 3T, which nulls the signal of cerebrospinal fluid [CSF]).…”

mentioning

confidence: 99%

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Fluid and white matter suppression with the MP2RAGE sequence

Tanner

Gambarota

Kober

et al. 2011

Magnetic Resonance Imaging

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Purpose: To develop a magnetic resonance imaging (MRI) sequence (fluid and white matter suppression, FLAWS) for generating two sets of images from a single acquisition: one with contrast similar to a T1-weighted magnetizationprepared rapid gradient-echo sequence (MPRAGE) for structural definition; the other with nulled white matter (WM) signal intensity, similar to the fast gray matter T1 inversion recovery (FGATIR) sequence, for improved delineation of subcortical brain structures. Materials and Methods:The recently proposed MP2RAGE, which is a modification of the MPRAGE and generates two image sets at different inversion times, was employed to generate the FGATIR-like contrast (FLAWS1) and MPRAGE-like contrast (FLAWS2). Five healthy volunteers were scanned at 3T and brain tissue contrast and contrast-to-noise were compared.Results: FLAWS1 and FLAWS2 exhibited similar tissue contrast and contrast-to-noise as the ''reference'' sequences, FGATIR and MPRAGE, respectively. Synthetic minimum value images generated from FLAWS1 and FLAWS2 provided a gray matter-dominant image.Conclusion: FLAWS provides two coregistered 3D volumes, one with nulled WM signal intensity and another with nulled cerebrospinal fluid. The coregistered nature of the two datasets allows for generating images that might be helpful in segmentation algorithms and clinical diagnosis.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Fluid and white matter suppression with the MP2RAGE sequence

Tanner

Gambarota

Kober

et al. 2011

Magnetic Resonance Imaging

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“…The sequence used in this study has often been used in the assessment of brain iron deposits 24,25 ; however, it has recently been demonstrated that techniques that rely on the signal phase, namely quantitative susceptibility mapping, are more accurate than transverse relaxation times in terms of iron quantification. 26,27 Nevertheless, the production of susceptibility maps requires particular acquisition settings: in most quantitative susceptibility mapping implementations such as ours, the MR imaging system is programmed to provide the complex MR imaging data divided into real and imaginary parts, which are of no radiologic use.…”

Section: Methodologic Considerationsmentioning

confidence: 99%

Semiautomated Evaluation of the Primary Motor Cortex in Patients with Amyotrophic Lateral Sclerosis at 3T

Donatelli¹,

Retico

Ienco

et al. 2017

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Amyotrophic lateral sclerosis is a neurodegenerative disease involving the upper and lower motor neurons. In amyotrophic lateral sclerosis, pathologic changes in the primary motor cortex include Betz cell depletion and the presence of reactive iron-loaded microglia, detectable on 7T MR images as atrophy and T2*-hypointensity. Our purposes were the following: 1) to investigate the signal hypointensity-to-thickness ratio of the primary motor cortex as a radiologic marker of upper motor neuron involvement in amyotrophic lateral sclerosis with a semiautomated method at 3T, 2) to compare 3T and 7T results, and 3) to evaluate whether semiautomated measurement outperforms visual image assessment.

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“…[11][12][13] Echo formation was achieved by successively inverting the readout gradient and acquiring all echoes under the same readout gradient polarity to avoid artifacts. Imaging parameters were linear TE increase from 10 to 52 ms with a constant increment of 6 ms, repetition time 1500 ms, flip angle 30°, field-of-view 240×180 mm 2 , matrix size 192×144 (readout×phase encoding), 25 axial slices, slice thickness 2 mm, no interslice gap, bandwidth=299 Hz/Px, measurement time 3:36 minutes.…”

Section: Mri Protocolmentioning

confidence: 99%

“…Median age of the 11 patients (5 men) was 71 (60, 77) years, median National Institutes of Stroke Scale score at admission was 15 (12,18). Six patients had proximal middle cerebral artery occlusion, 1 had middle cerebral artery branch occlusion and 4 had combined internal carotid artery and middle cerebral artery occlusion.…”

Section: Clinical Datamentioning

confidence: 99%

Quantitative T2′-Mapping in Acute Ischemic Stroke

Bauer

Wagner

Seiler

et al. 2014

Stroke

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Background and Purpose-Quantitative T2′-mapping detects regional changes in the relation of oxygenated and deoxygenated haemoglobine and might reflect areas with increased oxygen extraction. T2′-mapping in conjunction with an elaborate algorithm for motion correction was performed in patients with acute large-vessel stroke, and quantitative T2′-values were determined within the diffusion-weighted imaging lesion and perfusion-restricted tissue. Methods-Eleven patients (median age, 71 years) with acute middle cerebral or internal carotid artery occlusion underwent MRI before scheduled endovascular treatment. MR-examination included diffusion-and perfusion-weighted imaging and quantitative, motion-corrected mapping of T2′. Time-to-peak maps were thresholded for different degrees of perfusion delays (eg, ≥0 s, ≥ 2s) when compared with a reference time-to-peak value from healthy contralateral tissue.

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Quantitative mapping of T1 and T2* discloses nigral and brainstem pathology in early Parkinson's disease

Cited by 137 publications

References 62 publications

Fluid and white matter suppression with the MP2RAGE sequence

Fluid and white matter suppression with the MP2RAGE sequence

Semiautomated Evaluation of the Primary Motor Cortex in Patients with Amyotrophic Lateral Sclerosis at 3T

Quantitative T2′-Mapping in Acute Ischemic Stroke

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