Quantitative Mass Spectrometry in Support of Pharmacokinetic Studies

Xu, Xiao‐Ying; Li, Wenkui

doi:10.1002/9781118180730.ch7

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…The current best industry practice of validating an LC-MS/MS method and applying it for sample analysis suggested that accuracy is determined by replicate analysis of samples (QCs) containing known amounts of the analyte. The mean measured value should be within 15% (bias) of the nominal value for all QC concentration levels except for the LLOQ, where the bias (%) should be within 20% [ 24 , 25 ].…”

Section: Resultsmentioning

confidence: 99%

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Simultaneous Determination and Stability Analysis of Ten New Psychoactive Substances including Synthetic Cathinones, Phenethylamines, and Ketamine Substitutes in Urine Using Liquid Chromatography-Tandem Mass Spectrometry

Yang

Lee

Tseng

et al. 2023

International Journal of Analytical Chemistry

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Knowing the stability of drugs is important to ensure accurate and reliable results of drug concentrations. This study evaluated the stability of ten new psychoactive substances (NPSs) in urine and methanol/water at different storage temperatures. Quantitative analyses were performed using liquid chromatography-tandem mass spectrometry. Three replicates of each storage condition were analyzed at day 0 and after 7, 14-, 30-, 60-, and 90 days with storage at +25°C, +4°C, and −20°C. For each analyte, the percent difference at each time interval from day 0 was calculated for each storage condition. Para-methoxyamphetamine (PMA), para-methoxymethamphetamine (PMMA), deschloroketamine (DCK), and 2-fluorodeschloroketamine (2-FDCK) were stable in urine, even when stored for 90-day periods at various temperatures. For synthetic cathinones, the concentrations declined over time at room temperature (+25°C) in urine but were relatively stable in methanol solvent with 0.1% formic acid. The significant degradation was found at +25°C, and the most excellent stability was shown by samples stored at −20°C. Phenethylamines (PMA and PMMA) and ketamine substitutes (DCK and 2-FDCK) were relatively more stable than synthetic cathinones (mephedrone, butylone, pentylone, ephylone, 4-MEAPP, and eutylone).

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Section: Resultsmentioning

confidence: 99%

“…Both intra- and interday precision were assessed across five batches with an acceptability criterion of ≤10%. A method accuracy limit of ±15% was used [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Simultaneous Determination and Stability Analysis of Ten New Psychoactive Substances including Synthetic Cathinones, Phenethylamines, and Ketamine Substitutes in Urine Using Liquid Chromatography-Tandem Mass Spectrometry

Yang

Lee

Tseng

et al. 2023

International Journal of Analytical Chemistry

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“…Triple quadrupoles (QqQ), can be used in quantitative analysis based on full scan, precursor ion scan, product ion scan or neutral loss scan for sensitive, accurate, and precise quantification. 39,40 However, the limitation of this system includes the fact that it is less useful in qualitative analysis.…”

Section: •1 Triple Quadrupole Instrumentmentioning

confidence: 99%

Paradigm Shift in the Arena of Sample Preparation and Bioanalytical Approaches Involving Liquid Chromatography Mass Spectroscopic Technique

Sharma

Dhakne

et al. 2019

ANAL. SCI.

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Sample preparation is a highly important and integral part of bioanalysis for cleaning up the complex biological matrices and thereby minimizing matrix effect. Matrix effect can jeopardize the precise quantification and adversely affect the reliability of liquid chromatography-mass spectrometry-based analytical results by alteration of analyte ionization. Matrix components result in suppression or enhancement of the intensity of analyte response. In spite of the high specificity and selectivity of tandem mass spectrometry, a relatively higher concentration of coeluted matrix elements present in biofluids may alter the efficiency of quantification of a bioanalytical method. Numerous literature reports different types of sample preparation techniques employed in bioanalysis. In this review, the strategies for selection of the appropriate sample clean-up technique in bioanalysis are discussed extensively. A paradigm shift in the arena of sample preparation and bioanalytical approaches involving the liquid chromatography-mass spectroscopic technique has been scrutinized. Current trends and possible future advancements in the field of biological sample extraction methods, including instrumental techniques are analyzed in detail.

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Stability of i.v. admixture containing metoclopramide, diphenhydramine hydrochloride, and dexamethasone sodium phosphate in 0.9% sodium chloride injection

Kintzel

Zhao

Sun

2014

American Journal of Health-System Pharmacy

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Quantitative Mass Spectrometry in Support of Pharmacokinetic Studies

Cited by 3 publications

References 18 publications

Simultaneous Determination and Stability Analysis of Ten New Psychoactive Substances including Synthetic Cathinones, Phenethylamines, and Ketamine Substitutes in Urine Using Liquid Chromatography-Tandem Mass Spectrometry

Simultaneous Determination and Stability Analysis of Ten New Psychoactive Substances including Synthetic Cathinones, Phenethylamines, and Ketamine Substitutes in Urine Using Liquid Chromatography-Tandem Mass Spectrometry

Paradigm Shift in the Arena of Sample Preparation and Bioanalytical Approaches Involving Liquid Chromatography Mass Spectroscopic Technique

Stability of i.v. admixture containing metoclopramide, diphenhydramine hydrochloride, and dexamethasone sodium phosphate in 0.9% sodium chloride injection

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