Quantitative MR Imaging of Brain Tissue and Brain Pathologies

Hattingen, Elke; Jurcoane, Alina; Nelles, Michael; Müller, Andreas; Nöth, Ulrike; Mädler, Burkhard; Mürtz, Petra; Deichmann, Ralf; Schild, Hans H.

doi:10.1007/s00062-015-0433-8

Cited by 17 publications

(10 citation statements)

References 23 publications

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“…Median number of tissue samples taken was 12 (range [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Samples were taken in 1 mm steps using a biopsy forceps.…”

Section: Histopathological Diagnosismentioning

confidence: 99%

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Stereotactic biopsy of brainstem lesions: 21 years experiences of a single center

et al. 2016

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Stereotactic biopsies are procedures performed to obtain tumor tissue for diagnostic examinations. Cerebral lesions of unknown entities can safely be accessed and tissue can be examined, resulting in correct diagnosis and according treatment. Stereotactic procedures of lesions in highly eloquent regions such as the brainstem have been performed for more than two decades in our department. In this retrospective study we focus on results, approaches, modalities of anesthesia, and complications. We performed a retrospective analysis of our prospective database, including 26 patients who underwent stereotactic biopsy of the brainstem between April 1994 and June 2015. All of the patients underwent preoperative MRI. Riechert-Mundinger-frame was used before 2000, thereafter the Leksell stereotactic frame was used. After 2000 entry and target points were calculated by using BrainLab stereotactic system. We evaluated histopathological results as well as further treatment; additionally we compared complications of local versus general anesthesia and complications of a frontal versus a trans-cerebellar approach. Median age of all patients was 33 years, and median number of tissue samples taken was 12. In all patients a final histopathological diagnosis could be established. 5 patients underwent the procedure under local anesthesia, 21 patients in general anesthesia. In 19 patients a frontal approach was performed, while in 7 patients a trans-cerebellar approach was used. Complications occurred in five patients. Thereby no significant difference was found with regard to approach (frontal versus trans-cerebellar) or anesthesia (local versus general). Stereotactic biopsies even of lesions in the brainstem are a save way to obtain tumor tissue for final diagnosis, resulting in adequate treatment. Approach can be trans-cerebellar or frontal and procedure can be performed either under local or general anesthesia without significant differences concerning complication rate.

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“…Median number of tissue samples taken was 12 (range [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Samples were taken in 1 mm steps using a biopsy forceps.…”

Section: Histopathological Diagnosismentioning

confidence: 99%

“…The authors found MRS to be a reliable tool in grading gliomas, but they agree that also MRS is a tool used to guide stereotactic surgery rather than to replace it [1]. Hattingen et al give a good overview of quantitative MRI measurements, which are also used to monitor tumor tissue reactions to therapy [9].…”

Section: Compliance With Ethical Standardsmentioning

confidence: 99%

Stereotactic biopsy of brainstem lesions: 21 years experiences of a single center

et al. 2016

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“…velopment. Thus it was shown that by determining relaxation parameters and calculating synthetic tissue maps, acute inflammatory lesions and their disruption of the blood-brain barrier could also possibly be identified without administration of contrast [71].…”

Section: New Imaging Technologies For the Diagnosis Of Msmentioning

confidence: 99%

Brain and Spinal Cord MRI in Multiple Sclerosis: an Update

Wattjes

Raab

2017

Neurology International Open

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AbstR Ac tMagnetic resonance imaging (MRI) plays an important role in the diagnosis of multiple sclerosis and has been incorporated into the McDonald diagnostic criteria for MS. In particular, for the exclusion of important differential diagnosis and comorbidities, new MRI markers have been established such as the "central vein sign". In addition to diagnostic purposes, the role of MRI in MS monitoring is becoming increasingly important, particularly for pharmacovigilance. This includes treatment efficacy monitoring, prediction of treatment response and safety monitoring. Quantitative MRI methods and ultra-highfield MRI offer the opportunity for the quantitative assessment of damage in normal-appearing brain tissue. However, the standardization of these techniques with the goal of implementation in clinical routine will be one of the major challenges in the near future.

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“…Auch eher ältere MR-Methoden wie die quantifizierende Bestimmung der T1-, T2*-und T2-Relaxationszeiten sowie ihrer Relaxationsraten R (1/T) werden durch die zunehmende Qualität der Magnetfeldhomogenitäten und Sequenzentwicklung wieder verstärkt beachtet. So konnte gezeigt werden, dass durch die Bestimmung von Relaxationsparametern und die Berechnung von synthetischen Gewebekarten akute Entzündungsherde und ihre Störung der Blut-Hirn-Schranke auch ohne Gabe von Kontrastmittel identifiziert werden können [72]. ▶ Abb.…”

Section: Neue Bildgebungstechniken Für Die Ms-diagnoseunclassified

Zerebrale und spinale Bildgebung der Multiplen Sklerose: ein Update

Wattjes

Raab

2017

Akt Neurol

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ZusammenfassungDie Magnetresonanztomografie spielt in der Diagnostik der Multiplen Sklerose (MS) eine entscheidende Rolle und wurde deshalb innerhalb der MS-Diagnosekriterien verankert. Insbesondere für den Ausschluss wichtiger Differenzialdiagnosen werden immer neue MRT-Marker etabliert, wie beispielsweise das sogenannte „central vein sign“. Neben der Diagnostik hat die MRT in der MS-Verlaufsbeobachtung, und hierbei insbesondere bei der Pharmakovigilanz, eine zunehmende klinische Relevanz erlangt. Dies beinhaltet nicht nur die Erfassung der Behandlungseffektivität, sondern auch die Prädiktion des Behandlungserfolges und das Sicherheitsmonitoring. Quantitative MRT-Methoden sowie der Einsatz der (Ultra-)Hochfeld-MRT bieten uns in zunehmendem Maße die Möglichkeit, die MS-Pathologie insbesondere in auf dem konventionellen MRT-Bild normal erscheinendem Gewebe zu erfassen und zu quantifizieren. Dennoch wird die Standardisierung dieser Techniken für die MS-Diagnostik und Verlaufsbeobachtung zu den großen Herausforderungen in der Zukunft zählen, um damit diese vielversprechenden Methoden in die klinische Routine zu implementieren und zu etablieren.

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Quantitative MR Imaging of Brain Tissue and Brain Pathologies

Cited by 17 publications

References 23 publications

Stereotactic biopsy of brainstem lesions: 21 years experiences of a single center

Stereotactic biopsy of brainstem lesions: 21 years experiences of a single center

Brain and Spinal Cord MRI in Multiple Sclerosis: an Update

Zerebrale und spinale Bildgebung der Multiplen Sklerose: ein Update

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