Quantitative Musculoskeletal Tumor Imaging

Howe, Benjamin M.; Broski, Stephen M.; Littrell, Laurel A.; Pepin, Kay M.; Wenger, Doris E.

doi:10.1055/s-0040-1708825

Cited by 7 publications

(5 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has emerged as a valuable tool for sarcoma grading, prognostication, and evaluation of treatment response. 13 Historically, in contrast, arguably the most frequently used biomarkers in nononcologic orthopaedic surgery are angular measurements derived from standardized conventional radiographs used in diagnosis and treatment planning, whether in diagnosing developmental dysplasia of the hip 14 or in treating idiopathic scoliosis. 15 For the advancement of quantitative imaging and the use of imaging biomarkers in clinical trials and clinical practice, the Quantitative Imaging Biomarkers Alliance was organized in 2007 with the help of the Radiological Society of North America, with close collaboration with the European Imaging Biomarkers Alliance (EIBALL), a subcommittee of the European Society of Radiology.…”

Section: Imaging Biomarkersmentioning

confidence: 99%

Section: Imaging Biomarkersmentioning

confidence: 99%

See 1 more Smart Citation

Radiomics in Musculoskeletal Tumors

Brandenberger,

White

2024

Semin Musculoskelet Radiol

View full text Add to dashboard Cite

Sarcomas are heterogeneous rare tumors predominantly affecting the musculoskeletal (MSK) system. Due to significant variations in their natural history and variable response to conventional treatments, the discovery of novel diagnostic and prognostic biomarkers to guide therapeutic decision-making is an active and ongoing field of research. As new cellular, molecular, and metabolic biomarkers continue to be discovered, quantitative radiologic imaging is becoming increasingly important in sarcoma management. Radiomics offers the potential for discovering novel imaging diagnostic and predictive biomarkers using standard-of-care medical imaging. In this review, we detail the core concepts of radiomics and the application of radiomics to date in MSK sarcoma research. Also described are specific challenges related to radiomic studies, as well as viewpoints on clinical adoption and future perspectives in the field.

show abstract

Section: Imaging Biomarkersmentioning

confidence: 99%

Section: Imaging Biomarkersmentioning

confidence: 99%

Radiomics in Musculoskeletal Tumors

Brandenberger,

White

2024

Semin Musculoskelet Radiol

View full text Add to dashboard Cite

show abstract

“…DWI is a relatively new MRI sequence that provides qualitative and quantitative information on the cellularity of a lesion by measuring the Brownian motion of water molecules within the tissue [69,73,74]. The random motion of water molecules in tissue is the basis of the signal in DWI [75].…”

Section: Principles Of Dwimentioning

confidence: 99%

“…The specificity of the ADC value is reduced when the T2 signal intensity of the le sion is markedly hypointense or hyperintense [73]. It is essential to compare DWI and ADC in conjugation with conventional MRI.…”

Section: Pitfalls Of Dwi and Adc Mapmentioning

confidence: 99%

Pitfalls of Diffusion-Weighted Imaging: Clinical Utility of T2 Shine-through and T2 Black-out for Musculoskeletal Diseases

et al. 2023

View full text Add to dashboard Cite

Diffusion-weighted imaging (DWI) with an apparent diffusion coefficient (ADC) value is a relatively new magnetic resonance imaging (MRI) sequence that provides functional information on the lesion by measuring the microscopic movement of water molecules. While numerous studies have evaluated the promising role of DWI in musculoskeletal radiology, most have focused on tumorous diseases related to cellularity. This review article aims to summarize DWI-acquisition techniques, considering pitfalls such as T2 shine-through and T2 black-out, and their usefulness in interpreting musculoskeletal diseases with imaging. DWI is based on the Brownian motion of water molecules within the tissue, achieved by applying diffusion-sensitizing gradients. Regardless of the cellularity of the lesion, several pitfalls must be considered when interpreting DWI with ADC values in musculoskeletal radiology. This review discusses the application of DWI in musculoskeletal diseases, including tumor and tumor mimickers, as well as non-tumorous diseases, with a focus on lesions demonstrating T2 shine-through and T2 black-out effects. Understanding these pitfalls of DWI can provide clinically useful information, increase diagnostic accuracy, and improve patient management when added to conventional MRI in musculoskeletal diseases.

show abstract

“…The T1- and T2-weighted images and chemical shift imaging differentiates tissue characteristics such as fat, fibrosis and chondroid components [ 1 , 2 ]. In addition, functional MRI, such as diffusion-weighted imaging, perfusion-weighted imaging, and magnetic resonance spectroscopy, provides more biomarker information [ 3 , 4 , 5 , 6 ]. Perfusion-weighted images are usually required to identify the vascularity and angiogenesis of tumors [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling Delay

et al. 2022

View full text Add to dashboard Cite

Arterial spin labeling (ASL) magnetic resonance imaging (MRI) is used to perform perfusion imaging without administration of contrast media. However, the reliability of ASL for musculoskeletal tumors and the influence of post-labeling delay (PLD) have not been fully clarified. This study aimed to evaluate the performance of ASL with different PLDs in the imaging of musculoskeletal tumors. Forty-five patients were enrolled and were divided into a malignant group, a hypervascular benign group, a hypovascular benign group and a control group. The tissue blood flow (TBF) of the lesions and normal muscles was measured and the lesion-to-muscle TBF ratio and differences were calculated. The results showed that both the TBF of lesions and muscles increased as the PLD increased, and the TBF of muscles correlated significantly and positively with the TBF of lesions (all p < 0.05). The TBF and lesion-to-muscle TBF differences of the malignant lesions were significantly higher than those of the hypovascular benign lesions and the control group in all PLD groups (all p < 0.0125) and only those of the hypervascular benign lesions in the longest PLD (3025 ms) group (p = 0.0120, 0.0116). In conclusion, ASL detects high TBF in malignant tumors and hypervascular benign lesions, and a longer PLD is recommended for ASL to differentiate musculoskeletal tumors.

show abstract

Quantitative Musculoskeletal Tumor Imaging

Cited by 7 publications

References 109 publications

Radiomics in Musculoskeletal Tumors

Radiomics in Musculoskeletal Tumors

Pitfalls of Diffusion-Weighted Imaging: Clinical Utility of T2 Shine-through and T2 Black-out for Musculoskeletal Diseases

Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling Delay

Contact Info

Product

Resources

About