Quantitative Optical Coherence Tomography Angiography Detects Retinal Perfusion Changes in Carotid Artery Stenosis

Pierro, Luisa; Arrigo, Alessandro; Crescenzo, Michele De; Aragona, Emanuela; Chiesa, Roberto; Castellano, Renata; Catenaccio, Barbara; Bandello, Francesco

doi:10.3389/fnins.2021.640666

Cited by 18 publications

(21 citation statements)

References 28 publications

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“…Two studies were removed because their population did not meet the interest, two studies lacked a control group, and two studies lacked sufficiently detailed data. Overall, thirteen studies ( Heßler et al, 2015 ; Sayin et al, 2015 ; Biberoğlu et al, 2017 ; Çakır et al, 2017 ; Wang et al, 2017 ; Lahme et al, 2018 ; Li et al, 2019 ; Biberoglu et al, 2020 ; Dagdelen and Muz, 2021 ; Pierro et al, 2021 ; Incekalan et al, 2022 ; Liu X. et al, 2022 ; Wan et al, 2022 ) were included. The screening process is shown in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies involving 419 eyes with ICAS and 398 eyes with healthy controls were identified. Eight studies ( Heßler et al, 2015 ; Sayin et al, 2015 ; Çakır et al, 2017 ; Lahme et al, 2018 ; Li et al, 2019 ; Pierro et al, 2021 ; Incekalan et al, 2022 ; Liu X. et al, 2022 ; Wan et al, 2022 ) were prospective, while four ( Biberoğlu et al, 2017 ; Wang et al, 2017 ; Biberoglu et al, 2020 ; Dagdelen and Muz, 2021 ) were retrospective in design. The mean age of patients with ICAS was between 62 and 68 years.…”

Section: Resultsmentioning

confidence: 99%

“…The majority of the eligible studies recruited patients with moderate to severe ICAS. Of the thirteen studies examined, eleven ( Heßler et al, 2015 ; Sayin et al, 2015 ; Biberoğlu et al, 2017 ; Wang et al, 2017 ; Çakır et al, 2017 ; Li et al, 2019 ; Biberoglu et al, 2020 ; Dagdelen and Muz, 2021 ; Pierro et al, 2021 ; Liu X. et al, 2022 ; Wan et al, 2022 ) utilized OCT to measure the thickness of the retina and choroid, while five ( Lahme et al, 2018 ; Pierro et al, 2021 ; Incekalan et al, 2022 ; Liu X. et al, 2022 ; Wan et al, 2022 ) opted for OCTA to evaluate vessel densities of the SCP, DCP, RPC, and CC. We deemed research scoring 6 or above on the NOS scale to be high quality.…”

Section: Resultsmentioning

confidence: 99%

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Changes in the retina and choroid in patients with internal carotid artery stenosis: a systematic review and meta-analysis

Hou,

Jie,

Liu

et al. 2024

Front. Neurosci.

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BackgroundInternal carotid artery stenosis (ICAS) is a prevalent vascular condition associated with ischemic cerebrovascular disease. The ophthalmic artery is the first branch of the internal carotid artery stenosis (ICA). Given the crucial role of the ICA in ocular perfusion, we aimed to assess the thickness and vessel density of the retina and choroid in individuals with ICAS.MethodsThe PubMed and Embase databases were searched from inception to 10 January 2023 for studies evaluating retinal and choroidal changes between ICAS patients and healthy controls using optical coherence tomography (OCT) or optical coherence tomography angiography (OCTA). Data of interest were extracted and analyzed using Stata software version 16.ResultsThirteen studies involving 419 ICAS eyes and 398 healthy eyes were included. The pooled results demonstrated that the average thickness of peripapillary retinal nerve fiber layer (pRNFL) (WMD = −0.26, 95% CI: −0.45 to −0.08, P = 0.005), ganglion cell complex (GCC) (WMD = −0.36, 95% CI: −0.65 to −0.06, P = 0.017), and choroid (WMD = −1.06, 95% CI: −1.59 to −0.52, P = 0.000), were significantly thinner in patients with ICAS than in healthy controls. The overall vessel density of the radial peripapillary capillaries (RPC) in whole-image scans was lower in ICAS patients than in healthy control subjects (WMD = −0.94, 95% CI: −1.49 to −0.39, P = 0.001). No differences were detected in the vessel density of the superficial capillary plexus (SCP) (WMD = −0.84, 95% CI: −1.15 to −0.53, P = 0.092), the deep capillary plexus (DCP) (WMD = −0.27, 95% CI: −0.56 to 0.03, P = 0.074), or the choriocapillaris (CC) (WMD = −0.39, 95% CI: −1.12 to 0.35, P = 0.300).ConclusionThis systematic review and meta-analysis demonstrated that ICAS can reduce the vessel density of the RPC and the thickness of the retina and choroid. The retinal and choroidal microvasculature is a potential biomarker of the initial signal of ICAS.Systematic review registrationhttps://inplasy.com/, identifier NPLASY202410038

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Changes in the retina and choroid in patients with internal carotid artery stenosis: a systematic review and meta-analysis

Hou,

Jie,

Liu

et al. 2024

Front. Neurosci.

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“… 73 , 74 Although no data on the BCAS-induced retinal tissue oxygenation are available, several studies have reported reduced retinal vascular density in subjects with carotid stenosis. 75 – 78 Indeed, a recent study established a relationship between retinal vascular perfusion and cerebral hemodynamics in subjects with internal carotid artery stenosis. 79 …”

Section: Discussionmentioning

confidence: 99%

Differential reductions in the capillary red-blood-cell flux between retina and brain under chronic global hypoperfusion

Leng

Şencan

et al. 2023

Neurophoton.

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Significance: It has been hypothesized that abnormal microcirculation in the retina might predict the risk of ischemic damages in the brain. Direct comparison between the retinal and the cerebral microcirculation using similar animal preparation and under similar experimental conditions would help test this hypothesis.Aim: We investigated capillary red-blood-cell (RBC) flux changes under controlled conditions and bilateral-carotid-artery-stenosis (BCAS)-induced hypoperfusion, and then compared them with our previous measurements performed in the brain.Approach: We measured capillary RBC flux in mouse retina with two-photon microscopy using a fluorescence-labeled RBC-passage approach. Key physiological parameters were monitored during experiments to ensure stable physiology.Results: We found that under the controlled conditions, capillary RBC flux in the retina was much higher than in the brain (i.e., cerebral cortical gray matter and subcortical white matter), and that BCAS induced a much larger decrease in capillary RBC flux in the retina than in the brain. Conclusions:We demonstrated a two-photon microscopy-based technique to efficiently measure capillary RBC flux in the retina. Since cerebral subcortical white matter often exhibits early pathological developments due to global hypoperfusion, our results suggest that retinal microcirculation may be utilized as an early marker of brain diseases involving global hypoperfusion.

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“…Atherosclerotic internal carotid artery stenosis (ICAS) accounts for about 20% cases of cerebral ischemia [ 2 ]. The present diagnostic tools for carotid artery assessment are based on imaging studies, including carotid Doppler ultrasonography, computed tomography, magnetic resonance, or conventional invasive angiography with a use of intravascular ultrasound (IVUS), and optical coherence tomography (OCT) [ 3 , 4 , 5 ]. They display the degree of ICAS, as well as carotid plaque morphology [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

microRNAs Associated with Carotid Plaque Development and Vulnerability: The Clinician’s Perspective

Badacz

Przewłocki

Legutko

et al. 2022

IJMS

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Ischemic stroke (IS) related to atherosclerosis of large arteries is one of the leading causes of mortality and disability in developed countries. Atherosclerotic internal carotid artery stenosis (ICAS) contributes to 20% of all cerebral ischemia cases. Nowadays, atherosclerosis prevention and treatment measures aim at controlling the atherosclerosis risk factors, or at the interventional (surgical or endovascular) management of mature occlusive lesions. There is a definite lack of the established circulating biomarkers which, once modulated, could prevent development of atherosclerosis, and consequently prevent the carotid-artery-related IS. Recent studies emphasize that microRNA (miRNA) are the emerging particles that could potentially play a pivotal role in this approach. There are some research studies on the association between the expression of small non-coding microRNAs with a carotid plaque development and vulnerability. However, the data remain inconsistent. In addition, all major studies on carotid atherosclerotic plaque were conducted on cell culture or animal models; very few were conducted on humans, whereas the accumulating evidence demonstrates that it cannot be automatically extrapolated to processes in humans. Therefore, this paper aims to review the current knowledge on how miRNA participate in the process of carotid plaque formation and rupture, as well as stroke occurrence. We discuss potential target miRNA that could be used as a prognostic or therapeutic tool.

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Quantitative Optical Coherence Tomography Angiography Detects Retinal Perfusion Changes in Carotid Artery Stenosis

Cited by 18 publications

References 28 publications

Changes in the retina and choroid in patients with internal carotid artery stenosis: a systematic review and meta-analysis

Changes in the retina and choroid in patients with internal carotid artery stenosis: a systematic review and meta-analysis

Differential reductions in the capillary red-blood-cell flux between retina and brain under chronic global hypoperfusion

microRNAs Associated with Carotid Plaque Development and Vulnerability: The Clinician’s Perspective

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