Quantitative Optical Coherence Tomography Angiography in Patients with Moyamoya Vasculopathy: A Pilot Study

Khan, Haaris M; Lo, Julian; Sarunic, Marinko V.; Gooderham, Peter; Yip, Samuel; Sheldon, Claire A.; Wirth, Magdalena A.

doi:10.1080/01658107.2021.1959619

Cited by 3 publications

(8 citation statements)

References 18 publications

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“…FAZ has been widely used to assess the retinal vascular changes in patients with systemic diseases and patients with ocular pathologies [28][29][30]. A trial [8] has reported that the association of FAZ between MMD patients and healthy subjects and FAZ value between MMD patients and healthy subjects is not significantly different, and those results are similar to these results in our study.…”

Section: Discussionsupporting

confidence: 91%

“…FD can be used to assess the function and structure of the blood vessel [14,22]. Some studies [8,23] have pointed out associations of FD between MMD patients and healthy subjects. And these results showed that FD value between MMD patients and healthy subjects has no significant difference.…”

Section: Discussionmentioning

confidence: 99%

“…It is urgent to prolong patient's life and improve the quality of the patient's life, but the detailed mechanism of MMD is still unknown. Interestingly, some studies [8,9] have reported that microvascular density and morphology in patients with MMD exhibit significant abnormalities. The specific impact of vein occlusions and retinal artery on preventing the progression of MMD in patients is still not clear.…”

Section: Introductionmentioning

confidence: 99%

“…The FAZ [15], which refers to a single-layered parafoveal capillary arcade, is a round capillary-free zone within the macula. Those results by Khan H M [8] have reported that FAZ can be used to calculate the diameter of blood vessel in patients with MMD, but the detailed relationship between FAZ and MMD patients is elusive. Optical coherence tomography angiography (OCTA) can be used to calculate the SD and VD, FD and VDI, FAZ according to those findings described in previous study [2].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Changes in Retinal Vascular Parameters and density in patients with Moyamoya disease: A retrospective Study

Wang,

Meng,

Song

et al. 2024

Ophthalmic Res

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Objective: This study aims to compare retinal vascular parameters and density in patients with Moyamoya disease using the optical coherence tomography angiography. Patients and Methods: This clinical trial totally enrolls 78 eyes from 39 participants, and all these patients with Moyamoya disease (N=13) are set as experimental group and participants with health who matched with age and gender are considered as the control group (N=26). Then all these participants receive Optical coherence tomography angiography detection. Participants’ general data are collected and analyzed. Skeleton density (SD) value, Vessel density (VD) value, Fractal dimension (FD) value, Vessel diameter index (VDI) value, Foveal Avascular Zone (FAZ) value are analyzed. Results: The total of 39 participants are included in this study. The SD value in the experimental group was significantly lower than that in control group [0.175 (0.166, 0.181) vs. 0.184 (0.175, 0.188), p=0.017]. Similarly, the VD value in the experimental group was significantly lower than that in the control group [0.333 (0.320, 0.350) vs. 0.354 (0.337, 0.364), p=0.024]. Additionally, the FD value in the experimental group was significantly lower than that in the control group [2.088 (2.083, 2.094) vs. 2.096 (2.090, 2.101), p=0.022]. As for the VDI and FAZ, VDI and FAZ values in the experimental group were lower than those in the control group, there was no significant difference in VDI and FAZ values between the two groups. Conclusions: Our study, using non-invasive and rapid OCTA imaging, confirmed decreased retinal vascular parameters and density in patients with moyamoya disease.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of Changes in Retinal Vascular Parameters and density in patients with Moyamoya disease: A retrospective Study

Wang,

Meng,

Song

et al. 2024

Ophthalmic Res

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“…In neuro-ophthalmology, OCTA was initially applied to glaucomatous optic neuropathy [ 7 , 17 ] or ischemic optic neuropathy to analyze microvascular abnormalities. Since then, it has been extended to diseases such as Leber hereditary optic neuropathy and optic neuritis [ 18 , 19 ] and has now been applied to vascular diseases of brain origin, such as moyamoya vasculopathy and multiple sclerosis [ 20 , 21 ]. To the best of the author’s knowledge, there have been no previous study on intraocular microvasculature analysis using OCTA in vascular paralytic strabismus.…”

Section: Discussionmentioning

confidence: 99%

Intraocular vascular analysis using optical coherence tomography angiography in patients with vascular paralytic strabismus

Lee

2022

PLoS ONE

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Purpose To investigate changes in peripapillary and macular vessel density (VD) in vascular paralytic strabismus using optical coherence tomography angiography (OCTA). Methods Medical records of patients who recovered from monocular vascular paralytic strabismus were retrospectively analyzed. Age, sex, presence of underlying diseases, strabismus type and severity, time to recovery, and visual acuity at diagnosis were evaluated. VD in the optic disc area and macular capillary plexus density were estimated using OCTA. The effect of paralytic strabismus on intraocular VD was investigated by comparing VD between the paralysis and contralateral eyes. To analyze hemodynamic changes, VD changes in the paralysis eye during the attack and recovery were compared. Results Thirty-one patients (mean age, 64.1±13.0 years; 21 males, 10 females) were included and mean recovery time was 3.0±1.6 months. The most common paralysis was sixth nerve palsy (54.8%). When comparing OCTA results between the paralysis and contralateral non-paralysis eyes, foveal VD in the superficial capillary plexus (SCP) was significantly lower in the paralysis eye (P = 0.034); however, VD in the optic disc area was not different. In the paralysis eye, foveal VD in the SCP significantly increased after paralysis recovery (P = 0.04). During attack, the maximal deviation angle and severity of duction limitation were significantly related to foveal VD in SCP. The greater the deviation angle and the more severe the eye movement restriction, the lower the foveal VD in SCP. Conclusions Transient retinal ischemia of the paralysis eye was observed in a patient with paralytic strabismus, which corresponded to the degree of deviation angle and ocular motor restriction. Ischemic factors, which are the etiology of vascular paralytic strabismus, affect intraocular blood flow.

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Insight into the Brain: Application of the Retinal Microvasculature as a Biomarker for Cerebrovascular Diseases through Optical Coherence Tomography Angiography

Wang,

Shah,

Llaneras

et al. 2023

Curr Ophthalmol Rep

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Quantitative Optical Coherence Tomography Angiography in Patients with Moyamoya Vasculopathy: A Pilot Study

Cited by 3 publications

References 18 publications

Comparison of Changes in Retinal Vascular Parameters and density in patients with Moyamoya disease: A retrospective Study

Comparison of Changes in Retinal Vascular Parameters and density in patients with Moyamoya disease: A retrospective Study

Intraocular vascular analysis using optical coherence tomography angiography in patients with vascular paralytic strabismus

Insight into the Brain: Application of the Retinal Microvasculature as a Biomarker for Cerebrovascular Diseases through Optical Coherence Tomography Angiography

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