Quantitative Optical Coherence Tomography Angiography Features and Visual Function in Eyes With Branch Retinal Vein Occlusion

Samara, Wasim A.; Shahlaee, Abtin; Sridhar, Jayanth; Khan, Mohammed; Ho, Allen C.; Hsu, Jason

doi:10.1016/j.ajo.2016.03.033

Cited by 162 publications

(167 citation statements)

References 21 publications

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“…FAZ enlargement is related to worse vision in diabetic retinopathy and retinal vein occlusions. 26,27 Capillary density of both plexuses is correlated to visual loss in diabetic retinopathy, 28 branch retinal vein occlusion, 29,30 and idiopathic macular telangiectasia type 1 (MacTel1). 31 In addition, several investigators have shown that decreased perfusion is more frequent in the deep than superficial plexus, in central or branch vein occlusion, 32-34 diabetic retinopathy, 35 and MacTel1.…”

Section: Discussionmentioning

confidence: 99%

Radiation Maculopathy After Proton Beam Therapy for Uveal Melanoma: Optical Coherence Tomography Angiography Alterations Influencing Visual Acuity

Matet

Daruich

Zografos

2017

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To analyze microvascular and structural changes in radiation maculopathy and their influence on visual acuity (VA), using optical coherence tomography (OCT) and OCT angiography (OCTA).METHODS. This was a retrospective analysis of consecutive patients with radiation maculopathy, 12 months or more after proton-beam irradiation for uveal melanoma, imaged with fluorescein angiography, OCT, and OCTA. Clinical parameters potentially affecting VA were recorded, including OCTA-derived metrics: foveal avascular zone (FAZ) area, vascular density, and local fractal dimension of the superficial (SCP) and deep capillary plexuses (DCP). Nonirradiated fellow eyes served as controls. RESULTS.Ninety-three patients were included. FAZ was larger, while SCP/DCP capillary density and local fractal dimension were lower in the 35 irradiated than in the 35 fellow eyes (P < 0.0001). Microvascular alterations graded on fluorescein angiography (minimally damaged/ disrupted/disorganized) were correlated to FAZ area and SCP/DCP density on OCTA (P < 0.01). By univariate analysis, worse VA was associated to macular detachment at presentation (P ¼ 0.024), total macular irradiation (P ¼ 0.0008), higher central macular thickness (CMT) (P ¼ 0.019), higher absolute CMT variation (P < 0.0001), cystoid edema (P ¼ 0.030), ellipsoid zone disruption (P ¼ 0.002), larger FAZ (P < 0.0001), lower SCP (P ¼ 0.001) and DCP capillary density (P < 0.0001), and lower SCP (P ¼ 0.009) and DCP local fractal dimension (P < 0.0001). Two multivariate models with either capillary density or fractal dimension as covariate showed that younger age (P ¼ 0.014/0.017), ellipsoid zone disruption (P ¼ 0.034/0.019), larger FAZ (P ¼ 0.0006/0.002), and lower DCP density (P ¼ 0.008) or DCP fractal dimension (P ¼ 0.012), respectively, were associated with worse VA.CONCLUSIONS. VA of eyes with radiation maculopathy is influenced by structural and microvascular factors identified with OCTA, including FAZ area and DCP integrity.

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Section: Discussionmentioning

confidence: 99%

Radiation Maculopathy After Proton Beam Therapy for Uveal Melanoma: Optical Coherence Tomography Angiography Alterations Influencing Visual Acuity

Matet

Daruich

Zografos

2017

Invest. Ophthalmol. Vis. Sci.

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“…[22][23][24][25] In addition, the OCTA has the potential to quantitatively analyze the retinal vessel density (VD) and the foveal avascular zone (FAZ) area. 26,27 Thus, OCTA has provided a better understanding of the relationship between the layerspecific retinal microvascular changes and the visual outcomes in patients with RVO. To date, several studies have reported the macular VD and FAZ before and after anti-VEGF therapy.…”

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confidence: 99%

Changes in Retinal Microvasculature and Visual Acuity After Antivascular Endothelial Growth Factor Therapy in Retinal Vein Occlusion

Winegarner

Wakabayashi

Fukushima

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To investigate the changes in the retinal microvasculature during the course of anti-VEGF therapy in eyes with macular edema due to retinal vein occlusion (RVO) and their association with visual outcomes.METHODS. The vessel density (VD) and foveal avascular zone (FAZ) area in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were quantitatively measured by optical coherence tomography angiography (OCTA) in 48 consecutive eyes with RVO before and 1, 3, 6, 9, and 12 months after anti-VEGF therapy. Anti-VEGF therapy was performed either with ranibizumab or aflibercept following a pro re nata (PRN) regimen. The correlation between post-treatment best-corrected visual acuity (BCVA) and changes in the retinal microvasculature evaluated by OCTA were assessed.RESULTS. The BCVA improved significantly at 12 months (P < 0.001). Better BCVA at 12 months was significantly associated with a better VD in the SCP and DCP both at baseline (R 2 ¼ 0.524, P < 0.001 and R 2 ¼ 0.457, P < 0.001, respectively) and at 12 months (R 2 ¼ 0.521, P < 0.001 and R 2 ¼ 0.662, P < 0.001, respectively). Overall, both VD and FAZ did not change significantly during the 12 months. However, the progression of nonperfusion was observed in the SCP in 6 (13%) eyes and in the DCP in 10 (21%) eyes. The number of macular edema recurrence was significantly associated with a decrease in the VD (P ¼ 0.006 [SCP] and P < 0.001 [DCP]) and less visual gain (P ¼ 0.02) after treatment.CONCLUSIONS. Anti-VEGF therapy maintains retinal perfusion in most patients with RVO. Preserving retinal perfusion is crucial for better visual outcomes.

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“…Samara et al [4] have shown the mean FAZ area in 17 eyes of branch retinal vein occlusion (BRVO) and 17 unaffected eyes. The mean superficial FAZ area was 0.312 mm 2 in BRVO eyes and 0.284 mm 2 in unaffected eyes (P = 0.54) whereas there was significant difference at the level of DCP between the BRVO and unaffected eyes (0.519 mm 2 vs 0.410 mm 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…It has also helped to understand the middle capillary plexus abnormality in retinal vascular diseases [6]. Normal measurements of volume density of capillary plexus and foveal avascular zone have also been reported [4, 5, 8]. All these were measured in area (mm 2 ) and predominantly in unilateral healthy eyes.…”

Section: Introductionmentioning

confidence: 99%

Diametric measurement of foveal avascular zone in healthy young adults using optical coherence tomography angiography

Hussain

Hussain²

2016

Int J Retin Vitr

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BackgroundThe objective of this study is to measure the diameter size of foveal avascular zone (FAZ) in both eyes of healthy young adults using optical coherence tomography (OCT) angiography.MethodsA cross sectional study to measure the foveal avascular zone in healthy young adults. Subjects underwent OCT angiography using Zeiss AngioPlex OCT angiography in both eyes.Results30 eyes of 15 healthy young adults were evaluated. The mean horizontal FAZ diameter of superficial vascular plexus was 661.166 ± 119.99 microns and mean vertical FAZ diameter was 660.033 ± 96.169 microns (P = 0.9442). The mean horizontal FAZ diameter of deep vascular plexus was 1011.2 ± 154.526 microns and the mean vertical FAZ diameter of deep vascular plexus was 818.033 ± 102.108 microns. There was no difference between the contralateral eyes of subjects in FAZ diameter of both superficial and deep capillary plexuses.ConclusionThe mean diametric size of FAZ in superficial capillary plexus is 660.599 ± 0.801 microns and deep capillary plexus is 914.616 ± 136.589 microns. There was no significant difference with the contralateral eyes.

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Quantitative Optical Coherence Tomography Angiography Features and Visual Function in Eyes With Branch Retinal Vein Occlusion

Cited by 162 publications

References 21 publications

Radiation Maculopathy After Proton Beam Therapy for Uveal Melanoma: Optical Coherence Tomography Angiography Alterations Influencing Visual Acuity

Radiation Maculopathy After Proton Beam Therapy for Uveal Melanoma: Optical Coherence Tomography Angiography Alterations Influencing Visual Acuity

Changes in Retinal Microvasculature and Visual Acuity After Antivascular Endothelial Growth Factor Therapy in Retinal Vein Occlusion

Diametric measurement of foveal avascular zone in healthy young adults using optical coherence tomography angiography

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