“…Since there are several studies using this cell line as an in vitro model for neurodegenerative disorders (Liu et al, 2018;Murillo et al, 2017;Xicoy, Wieringa, & Martens, 2017), particularly for investigation of Aβ toxicity and drug screening (Jämsä, Belda, Edlund, & Lindström, 2011;Lattanzio, Carboni, Carretta, Candeletti, & Romualdi, 2016;Yuan et al, 2017), our first objective was to compare the effect of the peptide on undifferentiated and differentiated cells. SH-SY5Y are neuroblast-like cells that can be differentiated into a mature neuronal phenotype using several differentiating agents, including RA, phorbol esters, and neurotrophins (Kovalevich & Langford, 2013).…”