1982
DOI: 10.1159/000182454
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Quantitative Structural Aspects of the Renal Glomeruli of Hypertensive Mice

Abstract: Kidneys of genetically hypertensive and normotensive mice were studied with respect to kidney weight, number and volume of glomeruli, and filtration surface area. The hypertensive animals have a larger kidney weight to body weight ratio and possess fewer glomeruli per kidney. The superficial cortical glomeruli of the hypertensives are slightly smaller in volume than those of the normotensives although the filtration surface area is similar. The juxtamedullary glomeruli of the hypertensives are both smaller in … Show more

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Cited by 6 publications
(4 citation statements)
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“…Hypertensive BPH/2 mice have similar kidney-to-body weight ratio as BPN/3 (Schlager et al, 1979) but have fewer nephrons per kidney (Rosenberg et al, 1982). Morphometric analysis of kidneys from older BPH/2 mice showed none of the characteristic features of renal parenchymal pathology (Rosenberg et al, 1979) indicating that major morphological differences in the kidney are not likely driving the hypertension.…”
Section: Heart Vessel and Kidney Structure And Functionmentioning
confidence: 99%
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“…Hypertensive BPH/2 mice have similar kidney-to-body weight ratio as BPN/3 (Schlager et al, 1979) but have fewer nephrons per kidney (Rosenberg et al, 1982). Morphometric analysis of kidneys from older BPH/2 mice showed none of the characteristic features of renal parenchymal pathology (Rosenberg et al, 1979) indicating that major morphological differences in the kidney are not likely driving the hypertension.…”
Section: Heart Vessel and Kidney Structure And Functionmentioning
confidence: 99%
“…Morphometric analysis of kidneys from older BPH/2 mice showed none of the characteristic features of renal parenchymal pathology (Rosenberg et al, 1979) indicating that major morphological differences in the kidney are not likely driving the hypertension. However, the available filtration surface area in juxtamedullary glomeruli in BPH/2 mice is less than half that of BPN/3 mice while the superficial cortical glomeruli were comparable between strains (Rosenberg et al, 1982). By contrast, it is the superficial glomeruli in BPH/2 mice that show reduced permeability of the basement membrane compared with BPN/3 mice but not the juxtamedullary glomeruli.…”
Section: Heart Vessel and Kidney Structure And Functionmentioning
confidence: 99%
See 2 more Smart Citations