Quantitative structure−activity relationship (QSAR) for neuroprotective activity of terpenoids

Neuroprotective effect of the marine macroalgaGelidiella acerosa: identification of active compounds through bioactivity-guided fractionation

“…The diterpene phytol has also been reported to possess antimicrobial potentials against Staphylococcus aureus and tuberculosis (Inoue et al 2005;Saikia et al 2010). Chang et al (2007) demonstrated that phytol exhibit neuroprotective effects on human neuroblastoma SH-SY5Y cells when evaluated in vitro by using a simulated ischemia model. In addition to the above-mentioned potentials, phytol holds an antioxidant and antinociceptive activity in in vitro and in vivo systems, respectively (Santos et al 2013).…”

Major selected monoterpenes α-pinene and 1,8-cineole found inSalvia lavandulifolia(Spanish sage) essential oil as regulators of cellular redox balance

“…Moreover, S. lavandulifolia essential oil has been previously reported as an important source of bioactive principles with potential natural antioxidant activity to prevent oxidative stress accompanying degenerative diseases (Tildesley et al, 2003). Monoterpenes contained in essential oil are the mainly responsible for the described activities (Chang et al, 2007;Perry et al, 2001;Savelev et al, 2004). Despite available research concerning the chemical characterization and activities of S. lavandulifolia essential oil (Herraiz-Peñalver et al, 2010), little is known about the role of its major monoterpenes as potential protective agents against oxidative damage at the central nervous system (CNS) level (MiticCulafic et al, 2009).…”

QSAR Study on Dual 5‐HT1A and 5‐HT1B Antagonists: An Insight into the Structural Requirement for Antidepressant Activity

“…TSAR has been employed to investigate the effect of L-alanine ester variation on the anti-HIV activity and cytotoxicity of phosphoramidate derivatives [26]. Recently, Chang and coworkers [27] have applied TSAR to investigate the in-vitro neuroprotective activity of terpenoids on human neuroblastoma SH-SY5Y cell lines and found that neuroprotection was mainly governed by lipophilicity, shape index, and electrostatic property of the terpenoids studied. The structural requirement for the antibacterial activities of a novel class of oxazolidinones against S. aureus ATCC-25923 has been analyzed using the minimum inhibitory concentration as an independent variable that varied from 0.25 -16 lg/mL [28].…”