Quantitative Studies of Cell Types in the Rat Hypophysis Following Unilateral Adrenalectomy

Functional Classification of Cell Types of the Anterior Pituitary Gland Accomplished by Electron Microscopy

“…Among many researchers, some claimed that ACTH might be secreted by acidophil cells (FINERTY and BRISENO-CASTREJON 1949), whereas others reported that the origin of ACTH seemed to be basophils (SMELSER 1944 (Fig. 14).…”

The Fine Structure of the Human Pituitary Chromophobe Adenoma with Special Reference to the Classification of this Tumor

“…The cell type concerning the production of ACTH has long been a matter of special controversy (FARQUHAR, 1957;FINERTY and BRISENO-CASTREJON, 1949;MARSHALL, 1951;LEZNOFF et al, 1962;RENNELS, 1964;SIPERSTEIN and ALISON, 1965;SMELSER, 1944 1) The longest dimension 2) The shortest dimension * Maximum diameter of the granules as determined from sectioned material ** Approximate diameter of the granules as conjectured from hormone assays ample, in the luteotroph. There may be a much more difference in the granule size between man and animal.…”

Localization of Adrenocorticotropic Hormone by Histochemical and Immunochemical Methods

“…Finerty and Briseno-Castrejon (15) recently reviewed the problem of the origin of adrenocorticotropic hormone and reported experiments which suggested that the hormone was secreted by the acidophil cells of the pituitary. Halmi (11), from similar experiments, felt that the hormone was possibly produced by a subclass of basophil cells.…”

“…This suggests that a rather large part of the hormone activity of this highly active ACTH preparation is associated with a relatively small fraction of precipitable antigen. DISCUSSION Finerty and Briseno-Castrejon (15) recently reviewed the problem of the origin of adrenocorticotropic hormone and reported experiments which suggested that the hormone was secreted by the acidophil cells of the pituitary. Halmi (11), from similar experiments, felt that the hormone was possibly produced by a subclass of basophil cells.…”