Quantitative trait loci affecting clinical mastitis and somatic cell count in dairy cattle

Klungland, Helge; Sabry, Ayman; Heringstad, B.; Olsen, Harald; Gomez‐Raya, Luis; Våge, Dag Inge; Olsaker, I.; Ødegård, Jørgen; Klemetsdal, G.; Schulman, Nina; Vilkki, Johanna; Ruane, J.; Aasland, Monica; Rønningen, K.; Lien, Sigbjørn

doi:10.1007/s00335001-2081-3

Cited by 103 publications

(49 citation statements)

References 35 publications

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“…Lactoferrin may be active in modulation and regulation of macrophages, lymphocytes and neutrophil function (Smith and Oliver, 1981;Sordillo et al, 1997). Due to its properties, lactoferrin is one of the more important factors that prevent and control mastitis in dairy cows Seyfert et al, 1996;Hirvonen et al, 1999;Klungland at al., 2001;Teng, 2002). Furthermore, SCC generally increases with advancing age and stage of lactation.…”

Section: Discussionmentioning

confidence: 99%

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Associations between bovine lactoferrin gene polymorphism and somatic cell count in milk

Wojdak-Maksymiec¹,

Kmiec²,

Ziemak³

2006

Vet. Med. - Czech

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ABSTRACT:The study included 124 Polish Black-and-White dairy cows of various share of the Holstein-Friesian (HF) breed. Lactoferrin (LTF) gene polymorphism was obtained with PCR-RFLP method using EcoRI enzyme. Two alleles of LTF, A and B, were found in the studied population. Their frequencies were 67.74% and 32.56%, respectively. The alleles controlled the occurrence of three genotypes: AA, BB and AB, of frequencies equal to 37.90%, 2.42% and 59.68%, respectively. It was established that statistically significant associations exist between the somatic cell count (SCC) and LTF genotype, lactation month and parity as well as the HF gene share. No significant association was found between somatic cell count and season. The highest somatic cell count (transformed to a logarithmic scale) was found in milk of the AB genotype, whereas the lowest one was found in cows of the AA genotype.

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Section: Discussionmentioning

confidence: 99%

“…Molecular genetic markers were also associated with changes in SCC (Ashwell et al, 1997;Zhang et al, 1998;Klungland et al, 2001).…”

mentioning

confidence: 99%

Associations between bovine lactoferrin gene polymorphism and somatic cell count in milk

Wojdak-Maksymiec¹,

Kmiec²,

Ziemak³

2006

Vet. Med. - Czech

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“…Therefore, the use of genetic markers to indicate resistance or susceptibility to mastitis or to better exploit the phenotypic information through genomic selection (GS) is an attractive proposition (Goddard and Hayes, 2007). At present, however, the available literature on GS and molecular markers for mastitis resistance mainly refer to dairy cattle (Klungland et al, 2001;Boichard et al, 2003;Schulman et al, 2004). In sheep, quantitative trait loci (QTL) influencing SCS have recently been detected (Rupp et al, 2003b;Gutierrez-Gil et al, 2007;Raadsma et al, 2009).…”

Section: Actual Situation and Prospects For Improvementmentioning

confidence: 99%

Genetic selection for reduced somatic cell counts in sheep milk: A review

Riggio

Portolano

2015

Small Ruminant Research

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a b s t r a c tMastitis is an inflammation of the udder, mainly caused by bacteria, and leads to economic loss, due to discarded milk, reduced milk production, reduced milk quality and increased health costs in both dairy sheep and cattle. Selecting for increased genetic resistance to mastitis can be done directly or indirectly, with the indirect selection corresponding to a prediction of the bacteriological status of the udder based on traits related to the infection. The most frequently used indirect method is currently milk somatic cell count (SCC) or somatic cell score (SCS). This review reports the state of the art relating to the genetic basis of mastitis resistance in sheep and explores the opportunities to use SCC as selection criterion in a breeding programme to improve resistance to mastitis in sheep, discussing the actual situation and prospects for improvement. It has been stressed, in particular, that although it is unlikely that selection for mastitis resistance by the farmers on their own will be successful, there is good prospect for genetic improvement if reliable pedigree and performance recording is implemented across flocks, combined with breeding value estimation. To achieve this, a strong and well-structured organization to implement and support the programme is essential.

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“…All three bovine selectin genes (SELP, SELL and SELE, also known as CD62P, L and E) are located near each other on BTA 16 in a putative mastitis-related quantitative trait locus (QTL) (Klungland et al, 2001;Sorensen et al, 2008;Sodeland et al, 2011). This observation potentially supports their importance in combatting bovine mastitis.…”

Section: Accepted Manuscriptmentioning

confidence: 78%

Bovine P-selectin mediates leukocyte adhesion and is highly polymorphic in dairy breeds

Chen

Cheng

Werling

et al. 2016

Research in Veterinary Science

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Quantitative trait loci affecting clinical mastitis and somatic cell count in dairy cattle

Cited by 103 publications

References 35 publications

Associations between bovine lactoferrin gene polymorphism and somatic cell count in milk

Associations between bovine lactoferrin gene polymorphism and somatic cell count in milk

Genetic selection for reduced somatic cell counts in sheep milk: A review

Bovine P-selectin mediates leukocyte adhesion and is highly polymorphic in dairy breeds

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