Quantitative Ultrasonic Detection of Parenchymal Structural Change in Diffuse Renal Disease

Garra, Brian S.; Insana, Michael F.; Sesterhenn, Isabell A.; Hall, Timothy J.; Wagner, Robert F.; Rotellar, C; Winchester, James F.; Zeman, Robert K.

doi:10.1097/00004424-199402000-00002

Cited by 38 publications

(23 citation statements)

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“…A number of experimental studies utilizing these models have been performed (Insana 1996;Hosokawa et al 1994;Garra et al 1994), including characterization of renal disease (Insana 1996;Garra et al 1994), liver disease (Stetson and Sommer 1997), breast tumors (Anderson et al 2001;Donohue et al 2001), skin (Fournier et al 2001) and atherosclerotic plaque (Moore et al 1998;Watson et al 2000;Nair et al 2001), among others. This general methodology has been applied by our research group for characterization of ocular tumors (Coleman et al 2004;Liu et al 2004;Silverman et al 2003) and prostate cancer (Feleppa et al 2002;Feleppa et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Improved visualization of high-intensity focused ultrasound lesions

Silverman

Muratore

Ketterling

et al. 2006

Ultrasound in Medicine & Biology

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Spectral parameter imaging in both the fundamental and harmonic of backscattered radiofrequency (RF) data was used for immediate visualization of high-intensity focused ultrasound (HIFU) lesion sites. A focused 5-MHz HIFU transducer with a coaxial 9-MHz focused single-element diagnostic transducer was used to create and scan lesions in chicken breast and freshly excised rabbit liver. Bmode images derived from the backscattered RF signal envelope were compared with midband fit (MBF) spectral parameter images in the fundamental (9-MHz) and harmonic (18-MHz) bands of the diagnostic probe. Images of HIFU-induced lesions derived from the MBF to the calibrated spectrum showed improved contrast (~ 3 dB) of tumor margins versus surround compared to images produced from the conventional signal envelope. MBF parameter images produced from the harmonic band showed higher contrast in attenuated structures (core, shadow) compared to either the conventional envelope (3.3 dB core; 11.6 dB shadow) or MBF images of the fundamental band (4.4 dB core; 7.4 dB shadow). The gradient between the lesion and surround was 3.4 dB/mm, 6.9 dB/mm and 17.2 dB/mm for B-mode, MBF-fundamental mode and MBF-harmonic mode respectively. Images of threshold and 'popcorn' lesions produced in freshly excised rabbit liver were most easily visualized and boundaries best defined using MBF-harmonic mode.

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Section: Introductionmentioning

confidence: 99%

Improved visualization of high-intensity focused ultrasound lesions

Silverman

Muratore

Ketterling

et al. 2006

Ultrasound in Medicine & Biology

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“…Several important differences exist between biological tissues and the phantom studied in this work. Although spherical scatterers are well modeled by a spherical autocorrelation function, several researchers [20]- [22], [24], [25] have reported that tissue scatterers may be better described by Gaussian or exponential autocorrelation models. The scatterers in tissue typically exhibit more fluid-like properties than the glass bead scatterers in the phantom [15] and a more continuous distribution of sizes contributing to a smoother variation of the backscatter coefficient as a function of frequency than was observed from the glass bead phantom.…”

Section: Discussionmentioning

confidence: 99%

“…Once measured, the magnitudes and frequency dependences of the backscatter coefficient and attenuation may be used as quantitative indexes of material condition [ 131-1 181. Beyond this, several researchers have worked toward measurement of the size and scattering strength of the effective scatterers in biological tissue based on measurements of the backscatter coefficient [ 191- [25]. The transfer of measurement methods tested in an in vitro environment to an in vivo application is often impeded since many clinical measurements can be performed only in a single-transducer backscatter configuration.…”

Section: Introductionmentioning

confidence: 99%

Absolute backscatter coefficient over a wide range of frequencies in a tissue-mimicking phantom containing two populations of scatterers

Roberjot

Bridal

Laugier

et al. 1996

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Abstruct-The acquisition and interpretation of in vivo ultrasonic measurements in tissue encounter problems associated with limited access to the region of interest, intermixed scattering structures with different characteristic dimensions, and systemdependent effects. This work addresses these problems by adapting and testing a technique for measuring the absolute attennation and the absolute backscatter coefficient (effective backscatter cross section per unit volume of material), as a function of frequency, in a single-transducer backscatter configuration. The frequency-dependent attenuation and backscatter coefficients of a tissue-mimicking gelatin phantom containing a random distribution of two populations of scatterers were measured. Three transducers with different center frequencies and focusing characteristics were used in order to verify that system-dependent effects were removed by the technique and to investigate the change in the measured parameters across a broad range of frequencies (2 to 60 MHz). A spherical autocorrelation model was applied to measurements of the backscatter coefficient in order to estimate the size of scatterers. Measurements demonstrate that the backscatter and attenuation properties of a mixture of two distinct intermixed scatterer-size populations change as a function of the frequency range across which the model is applied. Comparison of both the magnitude and the frequency dependence of the experimental results with the theoretical prediction of the backscatter coefficient showed good agreement.

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“…4) and minimal change GN, cortical echogenicity is usually normal since glomerular component accounts only for 8% of renal parenchyma. Ultrasonic signal quantification techniques may reveal an increased glomerular diameter (>211 µm) [28]. As renal disease progresses, histological changes spread among the three primary parenchymal components, nephron, vessels and interstitium, and hyperechoic renal parenchyma results.…”

Section: Glomerulonephritis and Tubulo-interstitial Nephritismentioning

confidence: 99%

Renal parenchymal diseases: Is characterization feasible with ultrasound?

Quaia

Bertolotto

2002

Eur Radiol

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Ultrasound (US) imaging of the kidneys has greatly improved in recent years with introduction of wideband transducers and advances is beamformer technology. US is often the first imaging technique to be employed in patients with renal failure, haematuria or proteinuria, after clinical and laboratory evaluation. After conventional US evaluation, Doppler US (DUS) and resistive indices (RIs) analysis provide renal functional evaluation. Anyway, both sensitivity and specificity of conventional US and DUS in renal parenchymal disease evaluation remains low. In the initial or mild clinical stages of renal parenchymal diseases, kidneys may present normal US morphological appearance and normal RIs values, whereas different renal parenchymal diseases may reveal similar appearance on US and DUS evaluation. Besides, different renal parenchymal diseases may present some distinct features on conventional US and DUS with colour Doppler (CD) and power Doppler (PD) evaluation, even though percutaneous renal biopsy is often necessary to reach definite diagnosis. Renal vasculitides and tubular-interstitial nephropathies are more frequently identified by conventional US and DUS than glomerular nephropathies, since glomerular component accounts only for 8% of the renal parenchyma, whereas the highest percentage is occupied by vascular and tubulo-interstitial component. Follow-up of acute renal failure, during and after medical treatment, is the most useful field of employment of conventional US and DUS techniques, since a progressive lowering of RIs is correlated to a progressive recovery of renal function.

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Quantitative Ultrasonic Detection of Parenchymal Structural Change in Diffuse Renal Disease

Cited by 38 publications

References 0 publications

Improved visualization of high-intensity focused ultrasound lesions

Improved visualization of high-intensity focused ultrasound lesions

Absolute backscatter coefficient over a wide range of frequencies in a tissue-mimicking phantom containing two populations of scatterers

Renal parenchymal diseases: Is characterization feasible with ultrasound?

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