Quantitative videocapillaroscopy correlates with functional respiratory parameters: a clue for vasculopathy as a pathogenic mechanism for lung injury in systemic sclerosis

Guillén‐Del‐Castillo, Alfredo; Simeón-Aznar, Carmen Pilar; Callejas-Moraga, Eduardo L.; Tolosa-Vilella, Carles; Alonso-Vila, Serafín; Fonollosa-Plá, Vicente; Selva-O’Callaghan, Albert

doi:10.1186/s13075-018-1775-9

Cited by 33 publications

(63 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…active and late scleroderma pattern, or a conversion over time to worse scleroderma patterns, are associated with (incident) right heart catheterization defined SSc-PAH. Of note, post hoc, after the completion of this systematic review, a cross-sectional study by Guillén-Del-Castillo et al was published, reporting a negative correlation of higher capillary density and a positive correlation of number of abnormal shapes ("neoangiogenesis") with right ventricular systolic pressure in SSc-PAH patients compared to SSc-noPAH patients (38).…”

Section: Discussionmentioning

confidence: 93%

Nailfold Videocapillaroscopy in Systemic Sclerosis–related Pulmonary Arterial Hypertension: A Systematic Literature Review

Smith

Vanhaecke²,

Vandecasteele³

et al. 2019

J Rheumatol

View full text Add to dashboard Cite

Objective.Pulmonary arterial hypertension (PAH) is one of the leading causes of death in systemic sclerosis (SSc). Current screening algorithms are hampered by low positive predictive values. Outcome measures that could add to performance characteristics would be welcome. We aim to evaluate the role of nailfold videocapillaroscopy (NVC) using standardized definitions, in SSc-related PAH (SSc-PAH).Methods.A systematic review to identify original research papers documenting an association between NVC and right heart catheterization-defined SSc-PAH was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Subsequently, NVC characteristics were subdivided into quantitative (capillary density, dimension, morphology, and hemorrhages), semiquantitative, and qualitative assessment (NVC pattern), according to the definitions of the European League Against Rheumatism Study Group on Microcirculation in Rheumatic Diseases.Results.The systematic search identified 316 unique search results, of which 5 were included in the final qualitative analysis. The occurrence of incident SSc-PAH unequivocally associated in 2 longitudinal studies with progressive capillary loss (p = 0.04 and p = 0.033) and the progression to a severe (active/late) NVC pattern (p = 0.05/0.01 and HR = 5.12, 95% CI 1.23–21.27). In 3 cross-sectional studies, SSc-PAH was found to be unequivocally inversely associated with capillary density (p = 0.001 and p < 0.05) and associated with the presence of a severe NVC pattern (p = 0.03 and p < 0.05).Conclusion.This is the first systematic literature review investigating the role of NVC in SSc-PAH using standardized description, to our knowledge. Unequivocal associations were found between (incident) SSc-PAH and capillary density and NVC pattern. Integration of NVC into current screening algorithms to boost their performance may be a future step.

show abstract

Section: Discussionmentioning

confidence: 93%

Nailfold Videocapillaroscopy in Systemic Sclerosis–related Pulmonary Arterial Hypertension: A Systematic Literature Review

Smith

Vanhaecke²,

Vandecasteele³

et al. 2019

J Rheumatol

View full text Add to dashboard Cite

show abstract

“…Mean FVC was 73,83 (15,9)%, the regression rate for patients with ILD was 7,6 (6,73)%; mean DLCO was 60,82 (20,35)% and the mean regression rate for patients with ILD was 8(9,15)%. Mean sPAP was 32,49 (15,79)mmHg with a mean progression of 12,57 (15,11) mmHg.…”

Section: Resultsmentioning

confidence: 95%

“…Prior publications have found correlations between baseline specific quantitative NVC studies and lung function test or sPAP. The group of Guillén-Del-Castillo identified that the number of capillaries with neoangiogenesis, male gender and the presence of ILD on HRCT were factors independently associated with lower FVC values (15). SSc patients with ILD had a lower capillary density and a higher number of capillaries with neoangiogenesis.…”

Section: Discussionmentioning

confidence: 99%

The role of nailfold capillaroscopy in monitoring lung involvement in systemic sclerosis

Groşeanu¹,

Paraschiva²,

Bălănescu³

et al. 2019

Ro J Rheumatol.

View full text Add to dashboard Cite

The usefulness of capillaroscopy in the follow-up of scleroderma patients and the possible prognostic role for the appearance of visceral involvement is suggested by many authors but still under debate.The aim of this study was to assess the role of monitoring capillaroscopic abnormalities (qualitative and semiquantitative) in relation with parameters of interstitial lung involvement and pulmonary arterial hypertension(PAH). A strong correlation was identified between initial capillaroscopy scores and FVC (r=-.47, p=0.002), DLCO (r=-.51, p< 0.001) and sPAP (r=0.34, p<0.001). Active and late capillaroscopic pattern were correlated with diagnosis of lung fibrosis (χ2=14, p=0.007) and PAH at follow-up examinations (χ2=14,2, p=0.007). Progression of capillaroscopic pattern at follow-up evaluations was not correlated with significant worsening of lung volumes, DLCO, sPAP. Instead, progression of microangiopathy evolution score (>1) was asociated with worsening of FVC (r=0.32,p<0.001), DLCO(r=0.21,p=0.02) and new diagnosis of lung fibrosis on HRCT (r=0,19,p=0.035). Semiquantitative scoring, rather then qualitative capillaroscopic assessment can have a predictive role for new involvement or worsening of previous lung involvement (especially interstitial lung disease) in scleroderma patients, confirming the putative role of capillaroscopy as biomarker in SSc.

show abstract

“…Abs: autoantibodies, ILD: interstitial lung diseases, FTLs: fingertip lesions, NVC+: nailfold videocapillaroscopy positivity, PAH: pulmonary artery hypertension, RP: Raynaud's phenomenon, Skin: skin involvement and T: telangiectasia. According to SSc classification criteria [27], patients can be classified with a minimum of 9 points. FTL can be weighted with 2 or 3 points based on the presence of distal tip ulcers or pitting scars.…”

Section: Resultsmentioning

confidence: 99%

“…Actually, none of these factors have been proven to influence significantly NVC [23][24][25]. Conflicting results are also reported regarding the association between PFTs and NVC in SSc, no association was reported in IPF and evidences in other ILDs are totally lacking [26][27][28][29].…”

Section: Methodsmentioning

confidence: 99%

Nailfold Videocapillaroscopy Is a Useful Tool to Recognize Definite Forms of Systemic Sclerosis and Idiopathic Inflammatory Myositis in Interstitial Lung Disease Patients

Sambataro

Libra

et al. 2020

Diagnostics

View full text Add to dashboard Cite

Nailfold videocapillaroscopy (NVC) is an easy tool used for the assessment of patients with Raynaud’s phenomenon (RP) as possibly associated with systemic sclerosis (SSc). Recent insights have also highlighted its role in the diagnostic assessment of idiopathic inflammatory myopathies (IIMs). The aim of this study is to describe the diagnostic role of NVC in a series of 361 consecutive patients with interstitial lung disease (ILD). All the patients were assessed by clinical pulmonary and rheumatic examinations, blood exams, high-resolution computed tomography and NVC. NVC was considered positive only in the presence of avascular areas or giant capillaries, but also, the presence of bushy capillaries (BCs) was recorded. NVC was positive in 17.7% of ILD patients and in 78.1% of ILD patients associated with a diagnosis of connective tissue disease (CTD). In 25% of SSc-ILD patients, NVC proved necessary for a correct diagnosis. The presence of BCs and/or NVC positivity in ILD patients with normal levels of creatine phosphokinase is associated with amyopathic IIM, regardless the presence of RP. In conclusion, NVC is useful for the diagnostic assessment of incomplete forms of CTD and in amyopathic IIMs. NVC should be considered in the diagnostic assessment of ILD patients regardless of the presence of RP.

show abstract

Quantitative videocapillaroscopy correlates with functional respiratory parameters: a clue for vasculopathy as a pathogenic mechanism for lung injury in systemic sclerosis

Cited by 33 publications

References 45 publications

Nailfold Videocapillaroscopy in Systemic Sclerosis–related Pulmonary Arterial Hypertension: A Systematic Literature Review

Nailfold Videocapillaroscopy in Systemic Sclerosis–related Pulmonary Arterial Hypertension: A Systematic Literature Review

The role of nailfold capillaroscopy in monitoring lung involvement in systemic sclerosis

Nailfold Videocapillaroscopy Is a Useful Tool to Recognize Definite Forms of Systemic Sclerosis and Idiopathic Inflammatory Myositis in Interstitial Lung Disease Patients

Contact Info

Product

Resources

About