Quantum Dot-Based Dual-Color In Situ Fluorescence Imaging of the Coevolution of CD68 and CD47 in Breast Cancer

Shi, Xi; Yuan, Jingping; Dai, Yingying; Liu, Xing; Liu, Shu Lin; Wang, Zhi-Gang

doi:10.1021/acsanm.1c03816

Cited by 3 publications

(3 citation statements)

References 51 publications

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“…Furthermore, different functionalized quantum dots were employed for dual-color in situ fluorescence imaging to study the coevolution of CD68 and CD47 in breast cancer. This research utilized high spatial resolution imaging to provide the observable evidence of the interactions between cancer cells and macrophages, enhancing the understanding of the tumor microenvironment and its implications for cancer progression and prognosis [82].…”

Section: Quantum Dot Targeting and Detection Of Her2 In Breast Cancermentioning

confidence: 99%

Quantum Dot Research in Breast Cancer: Challenges and Prospects

Omidian,

Wilson,

Cubeddu

2024

Materials

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The multifaceted role of quantum dots (QDs) in breast cancer research highlights significant advancements in diagnostics, targeted therapy, and drug delivery systems. This comprehensive review addresses the development of precise imaging techniques for early cancer detection and the use of QDs in enhancing the specificity of therapeutic delivery, particularly in challenging cases like triple-negative breast cancer (TNBC). The paper also discusses the critical understanding of QDs’ interactions with cancer cells, offering insights into their potential for inducing cytotoxic effects and facilitating gene therapy. Limitations such as biocompatibility, toxicity concerns, and the transition from laboratory to clinical practice are critically analyzed. Future directions emphasize safer, non-toxic QD development, improved targeting mechanisms, and the integration of QDs into personalized medicine, aiming to overcome the current challenges and enhance breast cancer management.

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Section: Quantum Dot Targeting and Detection Of Her2 In Breast Cancermentioning

confidence: 99%

Quantum Dot Research in Breast Cancer: Challenges and Prospects

Omidian,

Wilson,

Cubeddu

2024

Materials

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“…Based on this, Shi et al synthesized a series of CdZnSeS QDs with well-controlled morphology, size distribution, monodispersity, and quantum yield exceeding 90% using a one-step synthesis method. 164 By modifying the surface with streptavidin (SA) and biotinylated goat antirabbit IgG, functionalized QDs-SA and QDs-IgG targeting CD68 and CD47 were constructed, enabling dual-color in situ fluorescence imaging of CD68 and CD47. The study demonstrated that controlling the orientation of targeted antibodies (Abs) can enhance targeting performance.…”

Section: Endowing Nanocrystals With Targeting Capabilitiesmentioning

confidence: 99%

“…Studies have indicated that simultaneous overexpression of CD68 and CD47 is a novel prognostic factor for BC, although there is no direct evidence supporting this conclusion. Based on this, Shi et al synthesized a series of CdZnSeS QDs with well-controlled morphology, size distribution, monodispersity, and quantum yield exceeding 90% using a one-step synthesis method . By modifying the surface with streptavidin (SA) and biotinylated goat antirabbit IgG, functionalized QDs-SA and QDs-IgG targeting CD68 and CD47 were constructed, enabling dual-color in situ fluorescence imaging of CD68 and CD47.…”

Section: Optimizing Nanocrystals Performance To Achieve Deep-tissue A...mentioning

confidence: 99%

Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region

Yang,

Jiang,

Zhang

2023

Chem. Rev.

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In vivo imaging technologies have emerged as a powerful tool for both fundamental research and clinical practice. In particular, luminescence imaging in the tissuetransparent near-infrared (NIR, 700−1700 nm) region offers tremendous potential for visualizing biological architectures and pathophysiological events in living subjects with deep tissue penetration and high imaging contrast owing to the reduced light−tissue interactions of absorption, scattering, and autofluorescence. The distinctive quantum effects of nanocrystals have been harnessed to achieve exceptional photophysical properties, establishing them as a promising category of luminescent probes. In this comprehensive review, the interactions between light and biological tissues, as well as the advantages of NIR light for in vivo luminescence imaging, are initially elaborated. Subsequently, we focus on achieving deep tissue penetration and improved imaging contrast by optimizing the performance of nanocrystal fluorophores. The ingenious design strategies of NIR nanocrystal probes are discussed, along with their respective biomedical applications in versatile in vivo luminescence imaging modalities. Finally, thought-provoking reflections on the challenges and prospects for future clinical translation of nanocrystal-based in vivo luminescence imaging in the NIR region are wisely provided.

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