Quantum dot-pseudopolyrotaxane supramolecules as anticancer drug delivery systems

Adeli, Mohsen; Hakimpoor, Farahman; Parsamanesh, Maasoomeh; Kalantari, Mahdieh; Sobhani, Zahra; Attyabi, Fatemeh

doi:10.1016/j.polymer.2011.02.032

Cited by 31 publications

(16 citation statements)

References 64 publications

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“…220,221 Through the integration of polyrotaxanes with some nanoparticles, such as quantum dots (QDs) and gold nanoparticles (AuNPs), drug delivery systems with new functions were prepared. 222,223 Another popular approach is self-assembly of polyrotaxanes to form supramolecular nanoparticles for the purpose of drug delivery. For example, α-CD/ PEG polyrotaxane-based supramolecular nanoparticles with a size around 200 nm were prepared by the self-assembly, and anticancer drug methotrexate (MTX) was loaded into the nanoparticles via hydrogen-bonding interaction.…”

Section: Drug Deliverymentioning

confidence: 99%

Biomedical Applications of Supramolecular Systems Based on Host–Guest Interactions

2014

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Section: Drug Deliverymentioning

confidence: 99%

Biomedical Applications of Supramolecular Systems Based on Host–Guest Interactions

2014

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“…PEG was functionalized using triazine according to a reported procedure . Typically, a solution of PEG (4 g, 4 × 10 −3 mol) and sodium hydroxide (0.32 g, 8 × 10 −3 mol) in 10 mL of water was added to a solution of cyanuric chloride (3.69 g, 2 × 10 −2 mol) in 50 mL of dichloromethane at 0 °C.…”

Section: Methodsmentioning

confidence: 99%

Synthesis of fluorescent ABA triblock copolymer via click reaction

Mohammadifar

Daneshnia

Kehtari

et al. 2016

Polymer International

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A hyperbranched-linear-hyperbranched (ABA) triblock copolymer containing poly(ethylene glycol) (PEG) as linear block and polyglycerol (hbPG) as hyperbranched blocks has been synthesized through a copper-catalysed click reaction. In order to synthesize the hyperbranched block, propargyl alcohol-initiated ring-opening multibranching polymerization of glycidol was used to prepare hbPG with the propargyl segment in the focal point (CH≡C-hbPG). Separately, PEG was functionalized at both ends using cyanuric chloride, and then the chloride groups of cyanuric chloride were substituted by azide groups. Finally, the azide-functionalized PEG was conjugated to CH≡C-hbPG via a click reaction. Substitution of the chlorine atoms of cyanuric chloride under different conditions together with click chemistry allows the synthesis of a variety of polymeric architectures. In the last step, fluorescein was attached to the block copolymer as a fluorescent probe in order to study the cell internalization of this copolymer. This type of triblock copolymer is a promising future nanomaterial for simultaneous drug delivery and cell imaging.

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“…For instance, a QD-pseudopolyrotaxane supramolecule system with high stability, targeted drug transportation and pH-sensitive release characteristics was presented for early diagnosis and therapy. 184 Another work of QD-based nanomaterial for pH-regulated drug delivery has been reported. 185 The in situ immobilization of hydroxypropylcellulose-poly(acrylic acid)-CdSe hybrid nanogels (HPC-PAA-CdSe) was utilized as pH-sensitive drug delivery systems based on its reversible swelling/shrinking transition owing to the pH-sensitive PAA chains.…”

Section: Qds For Drug Deliverymentioning

confidence: 99%

Quantum Dots (QDs) for Tumor Targeting Theranostics

Ma¹,

Shen²,

Zhang³

et al. 2016

Nanomaterials for Tumor Targeting Theranostics

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Semiconductor quantum dots exhibit excellent optical and electronic properties such as broad absorption, narrow emission, and remarkable photostability, rendering them promising candidates for a variety of applications. This chapter introduces the synthesis, surface functionalization, physicochemical properties, and biomedical applications of different types of quantum dots, with focus on their biomedical applications, such as biological imaging, targeted drug delivery and cancer therapy. A brief discussion on the toxicity of quantum dots, as well as the future directions of quantum dots nanotheranostics, is also presented.

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Quantum dot-pseudopolyrotaxane supramolecules as anticancer drug delivery systems

Cited by 31 publications

References 64 publications

Biomedical Applications of Supramolecular Systems Based on Host–Guest Interactions

Biomedical Applications of Supramolecular Systems Based on Host–Guest Interactions

Synthesis of fluorescent ABA triblock copolymer via click reaction

Quantum Dots (QDs) for Tumor Targeting Theranostics

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