Quantum Dots as A Theranostic Approach in Alzheimer’s Disease: A Systematic Review

Villalva, Maria D.; Agarwal, Vipul; Ulanova, Marina; Sachdev, Perminder S.; Braidy, Nady

doi:10.2217/nnm-2021-0104

Cited by 32 publications

(23 citation statements)

References 123 publications

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“…QDs are a class of nanoscale semiconductors that are highly stable and have high quantum yield, high absorbency, and high photobleaching resistance [92]. These can be used for the diagnosis and treatment of mitochondrial dysfunction in ADs [62,93,94]. This was verified by Hoshino et al's experiment which prepared mitochondrion-targeted QDs called Mit-8-QD that emitted red fluorescence as compared to non-mitochondrion targeting controls.…”

Section: Quantum Dot Nanoparticles (Qd Nps)mentioning

confidence: 93%

Nano-Theranostics Approaches and Mitochondrial Targeted Drug Delivery: Alzheimer ’s Disease Therapeutic Interventions

Chacko¹,

Nag²,

Dewanjee³

et al. 2022

Preprint

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One of the most frequent brain diseases, Alzheimer's is defined by poor cognitive function brought on by the build-up of Beta Amyloid plaques and the gradual death of neurons. Glucose metabolism and the development of amyloid plaques are being studied together. Under physiologically normal circumstances, glucose is the primary substrate for the adult human brain. The prodromal phases of AD are significantly influenced by glucose hypometabolism. Hypometabolism of glucose in the brain is a clear sign of mitochondrial dysfunction and bioenergetic system impairment. By regulating energy synthesis and cell death, mitochondria play a crucial role in the functioning of cells. Increased formation of reactive oxygen species (ROS) and oxidative stress are a result of mitochondrial dysfunction, which also accelerates the development of Alzheimer's disease. For the maintenance of balance, autophagy is crucial because it selectively destroys damaged mitochondria. AD affects this route for mitochondrial breakdown. Targeting specific mitochondrial ligands by interventions along this pathway might be a useful therapeutic approach. Due to a number of biological obstacles, this method has significant limitations. As a result, many nanocarriers have been created to improve drug delivery effectiveness. All potential nanotechnology-based treatments for AD have been examined in this study, with a particular emphasis on medication delivery to the mitochondria

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Section: Quantum Dot Nanoparticles (Qd Nps)mentioning

confidence: 93%

Nano-Theranostics Approaches and Mitochondrial Targeted Drug Delivery: Alzheimer ’s Disease Therapeutic Interventions

Chacko¹,

Nag²,

Dewanjee³

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…Several research articles have been published studying the QDs applications in diagnosing and treating Alzheimer's disease (AD). It has been proved that QDs have the ability to cross the BBB, whereas potential toxicity could be further evaluated [16].…”

Section: Quantum Dotsmentioning

confidence: 99%

“…Nanotechnology and nanomaterials open new avenues in biomedical science, as multiple nanoparticles have been applied in brain studies and research, including quantum dots (QDs), polymeric nanoparticles, micelles, metallic nanoparticles, etc. [16]. These nano-scale materials possess unique characteristics such as small size due to which they can interact with the biological system at the molecular level, a high surface to volume ratio that can be mono or multifarious with surface modification, and good stability.…”

Section: Introductionmentioning

confidence: 99%

Applications of Various Types of Nanomaterials for the Treatment of Neurological Disorders

et al. 2022

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Neurological disorders (NDs) are recognized as one of the major health concerns globally. According to the World Health Organization (WHO), neurological disorders are one of the main causes of mortality worldwide. Neurological disorders include Alzheimer’s disease, Parkinson′s disease, Huntington′s disease, Amyotrophic lateral sclerosis, Frontotemporal dementia, Prion disease, Brain tumor, Spinal cord injury, and Stroke. These diseases are considered incurable diseases because no specific therapies are available to cross the blood-brain barrier (BBB) and reach the brain in a significant amount for the pharmacological effect in the brain. There is a need for the development of strategies that can improve the efficacy of drugs and circumvent BBB. One of the promising approaches is the use of different types of nano-scale materials. These nano-based drugs have the ability to increase the therapeutic effect, reduce toxicity, exhibit good stability, targeted delivery, and drug loading capacity. Different types and shapes of nanomaterials have been widely used for the treatment of neurological disorders, including quantum dots, dendrimers, metallic nanoparticles, polymeric nanoparticles, carbon nanotubes, liposomes, and micelles. These nanoparticles have unique characteristics, including sensitivity, selectivity, and the ability to cross the BBB when used in nano-sized particles, and are widely used for imaging studies and treatment of NDs. In this review, we briefly summarized the recent literature on the use of various nanomaterials and their mechanism of action for the treatment of various types of neurological disorders.

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“…Over the past decades, noteworthy achievements were made to develop novel nanotechnology-based systems for therapeutic delivery of natural antioxidants to enhance antioxidant bioavailability and clinical efficacy for the therapy and prevention of neurodegenerative diseases [ 192 , 194 ]. Nanotechnological approaches (in particular quantum dots) can be employed to penetrate the BBB due to their small size and deliver antioxidants at high enough concentrations to mitigate oxidative stress in neurotrauma and neurodegenerative diseases [ 195 , 196 ]. The use of artificial antioxidant systems such as bioinspired catalytic nanoparticles, nanoscale drug delivery systems loaded with enzymes, and other nanomaterials, were proven to be some effective strategies [ 197 ].…”

Section: Conclusion and The Future Outlookmentioning

confidence: 99%

Antioxidant for Neurological Diseases and Neurotrauma and Bioengineering Approaches

2021

Self Cite

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Antioxidants are a class of molecules with an innate affinity to neutralize reactive oxygen species (ROS), which are known to cause oxidative stress. Oxidative stress has been associated with a wide range of diseases mediated by physiological damage to the cells. ROS play both beneficial and detrimental roles in human physiology depending on their overall concentration. ROS are an inevitable byproduct of the normal functioning of cells, which are produced as a result of the mitochondrial respiration process. Since the establishment of the detrimental effect of oxidative stress in neurological disorders and neurotrauma, there has been growing interest in exploring antioxidants to rescue remaining or surviving cells and reverse the neurological damage. In this review, we present the survey of different antioxidants studied in neurological applications including neurotrauma. We also delve into bioengineering approaches developed to deliver antioxidants to improve their cellular uptake in neurological applications.

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Quantum Dots as A Theranostic Approach in Alzheimer’s Disease: A Systematic Review

Cited by 32 publications

References 123 publications

Nano-Theranostics Approaches and Mitochondrial Targeted Drug Delivery: Alzheimer ’s Disease Therapeutic Interventions

Nano-Theranostics Approaches and Mitochondrial Targeted Drug Delivery: Alzheimer ’s Disease Therapeutic Interventions

Applications of Various Types of Nanomaterials for the Treatment of Neurological Disorders

Antioxidant for Neurological Diseases and Neurotrauma and Bioengineering Approaches

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