Quantum dots for electrochemiluminescence bioanalysis - A review

Yang, Erli; Zhang, Hongjie; Shen, Yanfei

doi:10.1016/j.aca.2021.339140

Cited by 57 publications

(26 citation statements)

References 126 publications

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“…In general, silica nanoparticles, carbon nanomaterials, metal organic frameworks (MOFs), and transition metal oxides are applied as nanocarriers to load QDs. To date, QD-based biosensors have been widely used for ultrasensitive analysis [ 66 , 67 , 68 , 69 ], which benefits from their unique features such as their excellent biocompatibility, water solubility, and low toxicity. Zhuo’s group [ 70 ] prepared IRMOF−3 accelerator-enriched QDs (CdTe@IRMOF−3@CdTe) using a direct encapsulation method for the trace detection of cTnI.…”

Section: Efficient Ecl Luminophoresmentioning

confidence: 99%

Strategies for Enhancing the Sensitivity of Electrochemiluminescence Biosensors

et al. 2022

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Electrochemiluminescence (ECL) has received considerable attention as a powerful analytical technique for the sensitive and accurate detection of biological analytes owing to its high sensitivity and selectivity and wide dynamic range. To satisfy the growing demand for ultrasensitive analysis techniques with high efficiency and accuracy in complex real sample matrices, considerable efforts have been dedicated to developing ECL strategies to improve the sensitivity of bioanalysis. As one of the most effective approaches, diverse signal amplification strategies have been integrated with ECL biosensors to achieve desirable analytical performance. This review summarizes the recent advances in ECL biosensing based on various signal amplification strategies, including DNA-assisted amplification strategies, efficient ECL luminophores, surface-enhanced electrochemiluminescence, and ratiometric strategies. Sensitivity-enhancing strategies and bio-related applications are discussed in detail. Moreover, the future trends and challenges of ECL biosensors are discussed.

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Section: Efficient Ecl Luminophoresmentioning

confidence: 99%

Strategies for Enhancing the Sensitivity of Electrochemiluminescence Biosensors

et al. 2022

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“…Quantum dots (QDs) or semiconductor nanocrystals (SNCs) exhibited unique optical and electronic properties, making them distinct from other nanomaterials [54][55][56][57][58][59][60][61][62][63][64][65][66] . QDs show good luminescence properties compared to organic and inorganic nanoparticles 45,[67][68][69][70][71] .…”

Section: Introductionmentioning

confidence: 99%

Selective Naked-eyes Chemosensing of Cu2+ ions using Chitosan-CdS Quantum Dots Biohybrid

Abdelhamid

Algethami

Saidi

et al. 2022

Preprint

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Cadmium sulfide (CdS) quantum dots (QDs) were homogeneously embedded into chitosan (CTS), denoted as CdS/CTS, via an in-situ solvothermal method. The intact structure of the synthesized materials was preserved via separating the materials using freeze-drying. The materials were characterized using X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscope (TEM), high-resolution TEM (HR-TEM), scanning TEM (STEM), dispersive energy X-ray (EDX) for elemental analysis and mapping, Fourier transform infrared (FT-IR), nitrogen adsorp-tion-desorption isotherms, thermogravimetric analysis, UV-Vis spectroscopy, and diffuse reflectance spectroscopy (DRS). The synthesis procedure offered CdS QDs with 1-7 nm (average particle size of 3.2 nm). The functional groups of CTS modulate the in-situ growth of CdS QDs and prevent the agglomeration of CdS QDs, offering homogenous distribution inside CTS. CdS/CTS QDs can also be used for naked-eye detection of heavy metals with high selectivity toward copper (Cu2+) ions. The mechanism of interactions between Cu2+ ions and CdS/CTS QDs was further studied

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“…Preparation of GQDs is cost effective; their toxicity is low, and they possess a large specific surface area and outstanding photoelectric properties compared to the conventional quantum dots. 19 It is well known that fluorescence turn-on-based sensing is superior to that of fluorescence turn-off-based sensing, which is attributed to a higher degree of selectivity, resolution, and lower potential errors for the former. 20 Also, fluorescence measurement-based sensing is straightforward and cost effective compared to other techniques such as high-performance liquid chromatography, 21 flow injection chemiluminescence, 22 radioimmunoassay, 23 micellar electrokinetic chroma-tography, 24 high-performance capillary electrophoresis, 25 etc.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Also, there are some advantages of using carbon-based quantum dots, such as their outstanding accessibility, stability, and biocompatibility. Preparation of GQDs is cost effective; their toxicity is low, and they possess a large specific surface area and outstanding photoelectric properties compared to the conventional quantum dots …”

Section: Introductionmentioning

confidence: 99%

Soot-Based Reduced Graphene Quantum Dot/Hemin Conjugate for Favipiravir Sensing

Hazarika

Kalita

Deka

et al. 2021

ACS Appl. Nano Mater.

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A conjugated system was synthesized from reduced graphene quantum dot (rGQD) and hemin for the selective detection of favipiravir (Fav), an antiviral drug that has come into much attention during the year 2020 for its use as a drug against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The required rGQD was prepared from soot particles using Hummers' method followed by the amino-hydrothermal process. At the first step, its fluorescence was quenched by preparing the conjugate with hemin. Interestingly, the fluorescence intensity gradually increases (turn-on) with increasing concentration of Fav, and develops 9-fold higher fluorescence at 15.6 nM of Fav. The fluorescence enhancement is selective, and the limit of detection (LOD) was calculated to be about 1.96 nM. The fluorescence turnon is governed by aggregation-induced emission (AIE), which originates from electrostatic interactions between the sensor−analyte systems. A similar fluorescence turn-on was observed for Fav in human blood plasma (BP) as well as in artificial urine (AU), which indicates that the sensor is viable in real-sample analysis. In addition to Fav, its 1:1 cocrystals with theophylline (Theo) and ferulic acid (FRA) also enhance the fluorescence in real samples with an LOD of 3.47 and 12.2 nM, respectively. Therefore, the cocrystals remain intact in biological medium and the sensor interacts with cocrystals too. The detection of Fav and its cocrystals, and the development of cocrystals as alternatives in the pharmaceutical industry, is essential considering the current COVID-19 pandemic worldwide. Therefore, the findings of this work will certainly help in developing fluorescence sensors for quantitative determination of active pharmaceutical ingredients (APIs) in real samples.

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Quantum dots for electrochemiluminescence bioanalysis - A review

Cited by 57 publications

References 126 publications

Strategies for Enhancing the Sensitivity of Electrochemiluminescence Biosensors

Strategies for Enhancing the Sensitivity of Electrochemiluminescence Biosensors

Selective Naked-eyes Chemosensing of Cu2+ ions using Chitosan-CdS Quantum Dots Biohybrid

Soot-Based Reduced Graphene Quantum Dot/Hemin Conjugate for Favipiravir Sensing

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