Quaternized carbon dots with enhanced antimicrobial ability towards Gram-negative bacteria for the treatment of acute peritonitis caused by E. coli

Abstract

Infection caused by Gram-negative bacteria is still a clinical dilemma. Although nanomaterials have been developed for antibacterial purposes, there is still a lack of systematic evaluation of the mechanisms and...

Antibacterial functionalized carbon dots and their application in bacterial infections and inflammation

“…106 Fortunately, inspired by FCDs applying in anti-inflammation and wound repair in vivo 107,108 and in the other models of inflammation, 109 more and more FCDs have been developed for treating bacterial infected wounds or inflammation. 71,110 However, CDs with antibacterial, antioxidant, or anti-inflammatory effects have rarely been reported. Therefore, developing CDs with multiple functions for application in nanomedicine is still challenging.…”

Flexible nanohybrid substrates utilizing gold nanocubes/nano mica platelets with 3D lightning-rod effect for highly efficient bacterial biosensors based on surface-enhanced Raman scattering

“…28 Staining divides bacteria into two major categories based on the different compositions and structures on the bacterial-cell wall: Gram-positive bacteria and Gram-negative bacteria. 29,30 Generally, teichoic acid, as a component in the cell wall, is unique to Gram-positive bacteria, which leads to more negative charges and hydrophilicity on the surface of positive bacteria. 31 In addition, Gram-negative bacteria do not contain teichoic acid, but contain components such as an outer membrane, lipoprotein, and lipopolysaccharide (LPS).…”

Low-Toxicity Antibacterial Carbon Nanodots for Wound Dressings and Food Packaging

“…The second scheme constantly suggested in the literature concerns the importance of positive charge on CDs surface. − It originates from the theory that lipopolysaccharides (Gram-negative) and teichoic acid polymers (Gram-positive) give bacteria cell wall an overall negative charge; and the affinity of CDs toward bacteria can be optimized by enhancing the surface positive charge of CDs. As bacteria develop, the molecular composition of their cell walls evolves.…”