Quaternized chitosan-stabilized copper sulfide nanoparticles for cancer therapy

Huang, Xiujie; Chen, Xu; Li, Yichen; Cheng, Haibo; Wang, Xiaoying; Sun, Run‐Cang

doi:10.1016/j.msec.2018.10.062

Cited by 50 publications

(25 citation statements)

References 48 publications

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“…The quaternization occurs with C 2 -NH 2 . Quaternization generally occurs via three methods, namely direct quaternary ammonium substitution, N-alkylation, and the epoxy derivative open loop method [65][66][67][68][69]. In recent years, the most commonly used quaternary ammonium salts have been GTA (2,3-epoxypropyl trimethyl ammonium chloride) and CTA (3-chloro-2-hydroxypropyl trimethyl) [15,70].…”

Section: Quaternary Ammonium Chitosanmentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

654

326

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Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

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Section: Quaternary Ammonium Chitosanmentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

654

326

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“…[1][2][3][4][5][6][7][8] Among them, copper chalcogenides, in particular, CuS nanoparticles (CuS NPs), with strong near-infrared (NIR) absorbance, good photostability, and low toxicity, are ideal candidates for in vivo PTT. [9][10][11][12][13][14][15][16][17][18] To date, CuS NPs have been widely synthesized by solvent-thermal or liquid precipitation methods. [18][19][20][21][22] Solvent-thermal method, in organic phase, however, requires high temperature and complex chemical modification for conversion of hydrophobic NPs to hydrophilic NPs.…”

Section: Introductionmentioning

confidence: 99%

Scalable Yielding of Highly Stable Polyelectrolyte‐Coated Copper Sulfide Nanoparticles by Flash Nanoprecipitation for Photothermal‐Chemotherapeutics

Jia

Yan

Kayitmazer

et al. 2021

Adv Funct Materials

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Photothermal‐chemotherapeutic nanoparticles (NPs) are attracting increasing attention and becoming more widely used for cancer therapy in the clinic due to their noninvasiveness, notable tissue penetration abilities, and low systemic adverse effects. However, functional ligands are conventionally modified onto photothermal NPs to well stabilize the inorganic particles suffering from complex chemical modifications, low productivity, and batch‐to‐batch inconsistencies, and thus significantly restricting their clinical applications. Herein, flash nanoprecipitation (FNP) is taken advantage of to afford rapid and uniform mixing for generating local supersaturated CuS clusters for small and highly stable CuS NPs effectively stabilized by polyacrylic acid through a continuous strategy. It greatly reduces the complexity for CuS NPs synthesis and functionalization in a facile intensified mixing process. These as‐synthesized particles are high‐drug loading, scalable, and most importantly, it is easy to control their sizes and charges through external conditions. Toxicity and tumor inhibition experiments confirm the high cell toxicity and good suppression of tumor growth under near‐infrared irradiation indicating a promising prospect of FNP in the large‐scale and continuous yielding of highly stable and high‐performing photothermal‐chemotherapeutic NPs for cancer therapy.

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“…Additionally, water-soluble hydroxyethyl chitosan provides modifiable functional groups, allowing the attachment of other compounds/drugs, and being a cationic polymer; it permits easy uptake through the negatively charged cell membrane [ 129 ]. Quaternized chitosan was used as a biotemplate and stabilizing agent during the green synthesis of CuS nanoparticles for photothermal based cancer therapy [ 130 ]. Chitosan coating of gold nanorods is shown to eliminate the cytotoxic effects of cetyltrimethylammonium bromide (CTAB) that is usually absorbed on to the surface of the nanorods after the synthesis process.…”

Section: Biomedical Applications Of Nanochitosanmentioning

confidence: 99%

Agricultural and Biomedical Applications of Chitosan-Based Nanomaterials

et al. 2020

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Chitosan has emerged as a biodegradable, nontoxic polymer with multiple beneficial applications in the agricultural and biomedical sectors. As nanotechnology has evolved as a promising field, researchers have incorporated chitosan-based nanomaterials in a variety of products to enhance their efficacy and biocompatibility. Moreover, due to its inherent antimicrobial and chelating properties, and the availability of modifiable functional groups, chitosan nanoparticles were also directly used in a variety of applications. In this review, the use of chitosan-based nanomaterials in agricultural and biomedical fields related to the management of abiotic stress in plants, water availability for crops, controlling foodborne pathogens, and cancer photothermal therapy is discussed, with some insights into the possible mechanisms of action. Additionally, the toxicity arising from the accumulation of these nanomaterials in biological systems and future research avenues that had gained limited attention from the scientific community are discussed here. Overall, chitosan-based nanomaterials show promising characteristics for sustainable agricultural practices and effective healthcare in an eco-friendly manner.

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Quaternized chitosan-stabilized copper sulfide nanoparticles for cancer therapy

Cited by 50 publications

References 48 publications

Chitosan Derivatives and Their Application in Biomedicine

Chitosan Derivatives and Their Application in Biomedicine

Scalable Yielding of Highly Stable Polyelectrolyte‐Coated Copper Sulfide Nanoparticles by Flash Nanoprecipitation for Photothermal‐Chemotherapeutics

Agricultural and Biomedical Applications of Chitosan-Based Nanomaterials

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