Quercetin 3-O-glucoside recovered from the wild Egyptian Sahara plant, Euphorbia paralias L., inhibits glutamine synthetase and has antimycobacterial activity

Safwat, Nesreen A.; Kashef, Mona T.; Aziz, Ramy K.; Amer, Khadiga F.; Ramadan, Mohamed A.

doi:10.1016/j.tube.2017.11.005

Cited by 38 publications

(36 citation statements)

References 31 publications

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“…This enzyme is normally found in the outer membrane of pathogenic mycobacteria that crucially involves in the synthesis of poly-L-glutamate-glutamine. quercetin plays a key function in regulating the cellular levels of NH3 in the infected host and eliminate the pathogen through phagosome acidification and phagosome-lysosome fusion [161]. Fatty acid synthase II (FAS-II) is a key enzyme, requires endogenous fatty acid synthesis in the bacterial membrane, represents a possible target for novel antimycobacterial agents [164].…”

Section: Inhibition Of Cell Wall Formationmentioning

confidence: 99%

“…A natural flavonoid, galangin pretreatment demonstrated to provide defensive functions against amikacin-provoked mitochondrial dysfunction by decreasing ROS generation [160]. The antioxidant properties of quercetin-3-O-β-d-glucoside prevent the formation of biofilm and encourage membrane disturbances, ensuing shrinkage of size and outflow of intracellular constituents of M. smegmatis [161]. In addition, quercetin accelerates the inhibition of mycobacterial glutamine synthetase.…”

Section: Inhibition Of Biofilm Formationmentioning

confidence: 99%

“…This enzyme is normally found in the outer membrane of pathogenic mycobacteria that crucially involves in the synthesis of poly-l-glutamate-glutamine. quercetin plays a key function in regulating the cellular levels of NH 3 in the infected host and eliminate the pathogen through phagosome acidification and phagosome-lysosome fusion [161].…”

Section: Inhibition Of Biofilm Formationmentioning

confidence: 99%

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Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria

2020

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Nontuberculous mycobacteria (NTM) are the causative agent of severe chronic pulmonary diseases and is accountable for post-traumatic wound infections, lymphadenitis, endometritis, cutaneous, eye infections and disseminated diseases. These infections are extremely challenging to treat due to multidrug resistance, which encompasses the classical and existing antituberculosis agents. Hence, current studies are aimed to appraise the antimycobacterial activity of flavonoids against NTM, their capacity to synergize with pharmacological agents and their ability to block virulence. Flavonoids have potential antimycobacterial effects at minor quantities by themselves or in synergistic combinations. A cocktail of flavonoids used with existing antimycobacterial agents is a strategy to lessen side effects. The present review focuses on recent studies on naturally occurring flavonoids and their antimycobacterial effects, underlying mechanisms and synergistic effects in a cocktail with traditional agents.

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Section: Inhibition Of Cell Wall Formationmentioning

confidence: 99%

Section: Inhibition Of Biofilm Formationmentioning

confidence: 99%

Section: Inhibition Of Biofilm Formationmentioning

confidence: 99%

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Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria

2020

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“…Activity of quercetin was detected using agar diffusion, broth microdilution, sulforhodamine B colorimetric assays and in vitro as well as molecular docking studies. Quercetin was found to inhibit all three strains of M. tuberculosis; the inhibition was directly proportional to quercetin concentration [89]. In another study, quercetin was used to target isocitrate lyase, an enzyme responsible for M. tuberculosis binding to host cells [89].…”

Section: Quercetinmentioning

confidence: 99%

“…Fluorescence quenching, Lineweaver-Burke plots, pocket detection algorithm and blind docking methodologies were used in this study. Quercetin was discovered to decrease M. tuberculosis isocitrate lyase, resulting in an increased inhibitory effect on M. tuberculosis metabolism [89]. Additionally, quercetin at 3.57 µM (IC 50 ) inhibited 25% of glucose metabolizing bacilli.…”

Section: Quercetinmentioning

confidence: 99%

The War against Tuberculosis: A Review of Natural Compounds and Their Derivatives

et al. 2020

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Tuberculosis (TB), caused by the bacterial organism Mycobacterium tuberculosis, pose a major threat to public health, especially in middle and low-income countries. Worldwide in 2018, approximately 10 million new cases of TB were reported to the World Health Organization (WHO). There are a limited number of medications available to treat TB; additionally, multi-drug resistant TB and extensively-drug resistant TB strains are becoming more prevalent. As a result of various factors, such as increased costs of developing new medications and adverse side effects from current medications, researchers continue to evaluate natural compounds for additional treatment options. These substances have the potential to target bacterial cell structures and may contribute to successful treatment. For example, a study reported that green and black tea, which contains epigallocatechin gallate (a phenolic antioxidant), may decrease the risk of contracting TB in experimental subjects; cumin (a seed from the parsley plant) has been demonstrated to improve the bioavailability of rifampicin, an important anti-TB medication, and propolis (a natural substance produced by honeybees) has been shown to improve the binding affinity of anti-TB medications to bacterial cell structures. In this article, we review the opportunistic pathogen M. tuberculosis, various potential therapeutic targets, available therapies, and natural compounds that may have anti-TB properties. In conclusion, different natural compounds alone as well as in combination with already approved medication regimens should continue to be investigated as treatment options for TB.

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Recent research progress in the plant contribution to the management of tuberculosis

Sieniawska

2024

eFood

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Quercetin 3-O-glucoside recovered from the wild Egyptian Sahara plant, Euphorbia paralias L., inhibits glutamine synthetase and has antimycobacterial activity

Cited by 38 publications

References 31 publications

Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria

Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria

The War against Tuberculosis: A Review of Natural Compounds and Their Derivatives

Recent research progress in the plant contribution to the management of tuberculosis

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