Quercetin and interferon-β modulate immune response(s) in peripheral blood mononuclear cells isolated from multiple sclerosis patients

Sternberg, Zohara; Chadha, Kailash C.; Lieberman, Alicia; Hojnacki, David; Drake, Allison; Zamboni, Paolo; Paluch, Rocco A.; Grazioli, Erica; Weinstock‐Guttman, Bianca; Munschauer, Frederick E.

doi:10.1016/j.jneuroim.2008.09.008

Cited by 106 publications

(58 citation statements)

References 48 publications

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“…It is an antioxidant, inhibiting lipid peroxidation and reducing oxidative stress (Jain et al, 2015;El-Shafey et al, 2014). Quercetin is a flavonoid compound that belongs to flavonol class and has strong antioxidant activity Sternberg et al, 2008;Boots et al, 2011). Naringin is another flavonoid found mainly in grapefruit and other citrus fruits.…”

Section: The Effects Of Dietary Flavonoid Supplementation On the Antimentioning

confidence: 99%

The Effects of Dietary Flavonoid Supplementation on the Antioxidant Status of Laying Hens

İskender

Yenice

Dokumacıoğlu

et al. 2016

Rev. Bras. Cienc. Avic.

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Ninety-six 28-week-old Lohmann White laying hens were utilized to test the antioxidant effects of flavonoids (hesperidin, naringin, and quercetin at 0.5 g/kg diet) during an 8-wk experimental period. At the end of the experiment blood samples were collected to determine total protein, cholesterol, and malondialdehyde (MDA) serum levels as well as activities of glutathione reductase (GR), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST), and superoxide dismutase (SOD) and level of glutathione (GSH) in erythrocyte lysates. Data were analyzed using one-way ANOVA. Naringin supplementation did not alter serum cholesterol concentration, whereas hesperidin and quercetin supplementations decreased serum cholesterol concentration. Naringin and quercetin supplementations did not affect serum protein concentration. All flavonoids decreased MDA concentration as well as increased GSH-Px, GR, GST, and SOD activities and GSH level, being quercetion superior to hesperidin and naringin. In conclusion, flavonoids, especially quercetin, exert antioxidant activity, which may help improve wellbeing when laying hens are exposed to stressors.

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Section: The Effects Of Dietary Flavonoid Supplementation On the Antimentioning

confidence: 99%

The Effects of Dietary Flavonoid Supplementation on the Antioxidant Status of Laying Hens

İskender

Yenice

Dokumacıoğlu

et al. 2016

Rev. Bras. Cienc. Avic.

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“…The need of cytokine-dependent inducibility of the MMP-9 gene promoter fits well with the dynamic ability of these cells to respond, in a spatially and chronologically defined manner, to autocrine and paracrine stimuli (Van den Steen et al, 2002): therefore, in a context of inflated flogosis, as observed in multiple sclerosis lesions, MMP-9 concentration is predictably aberrant. Nonetheless, therapeutical approaches, such as the administration of IFN-b and quercetin, decrease the MMP-9 expression in monocytes isolated from patients, lowering the MMP-9/ TIMP-1 ratio (Bernal et al, 2009;Sternberg et al, 2008;Yen et al, 2010).…”

Section: 242mentioning

confidence: 99%

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Sbardella

Fasciglione

Gioia

et al. 2012

Molecular Aspects of Medicine

209

212

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a b s t r a c tHuman matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site where a Zn 2+ atom, coordinated by three histidines, plays the catalytic role, assisted by a glutamic acid as a general base. Various MMPs display different domain composition, which is very important for macromolecular substrates recognition. Substrate specificity is very different among MMPs, being often associated to their cellular compartmentalization and/or cellular type where they are expressed. An extensive review of the different MMPs structural and functional features is integrated with their pathological role in several types of diseases, spanning from cancer to cardiovascular diseases and to neurodegeneration. It emerges a very complex and crucial role played by these enzymes in many physiological and pathological processes.

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“…The mechanism of bacterial antigens inducing the neuronal SP production and it´s binding to SP receptors, result in cytokine production and brain inflammation. Furthermore, products, such as SP receptor antagonists for the inhibition of NF-κB, or minocycline, -Lipoic acid, resveratrol [Aebischer & Kato;Lampl et al, 2007] or quercetin [Sternberg et al, 2008], which are known to be effective in the repair of BBB damaged by infections, may represent important new therapeutic strategies to combat potentially disabling consequences of inflammation within the brain.…”

Section: Induction Of Bbb Disruption and Neuroinflammation Mediated Bmentioning

confidence: 99%

Glial and Axonal Pathology in Multiple Sclerosis

Robinson-Agramonte¹,

González‐Quevedo²,

Gonçalves³

2012

Recent Advances in Immunology to Target Cancer, Inflammation and Infections

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Quercetin and interferon-β modulate immune response(s) in peripheral blood mononuclear cells isolated from multiple sclerosis patients

Cited by 106 publications

References 48 publications

The Effects of Dietary Flavonoid Supplementation on the Antioxidant Status of Laying Hens

The Effects of Dietary Flavonoid Supplementation on the Antioxidant Status of Laying Hens

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Glial and Axonal Pathology in Multiple Sclerosis

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