Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)

Biancatelli, Ruben Manuel Luciano Colunga; Berrill, Max; Catravas, John D.; Marik, Paul E.

doi:10.3389/fimmu.2020.01451

Cited by 424 publications

(393 citation statements)

References 129 publications

(134 reference statements)

Supporting

Mentioning

371

Contrasting

Unclassified

Order By: Relevance

“…This regime resulted in significant relieve of the patient’s symptoms. As vitamin C potentiates the pharmacological effect of flavonoid [ 55 ], the combined use of vitamin C and Quercetin (a flavonoid drug) could have a synergistic antiviral effect [ 90 ]. Having said that, there is a suggestion that vitamin C and Quercetin can be used as an adjunctive treatment to other promising drugs, such as remdesivir, in management of COVID-19 [ 90 ].…”

Section: The Beneficial Effect Of Vitamin C In Management Of Covid-19mentioning

confidence: 99%

“…As vitamin C potentiates the pharmacological effect of flavonoid [ 55 ], the combined use of vitamin C and Quercetin (a flavonoid drug) could have a synergistic antiviral effect [ 90 ]. Having said that, there is a suggestion that vitamin C and Quercetin can be used as an adjunctive treatment to other promising drugs, such as remdesivir, in management of COVID-19 [ 90 ]. Burn injury causes oxidative stress and generation of free radicals which lead to endothelial damage and increased capillary permeability [ 91 ].…”

Section: The Beneficial Effect Of Vitamin C In Management Of Covid-19mentioning

confidence: 99%

See 1 more Smart Citation

Overview of the possible role of vitamin C in management of COVID-19

2020

View full text Add to dashboard Cite

The mainstay of management of coronavirus disease 2019 (COVID-19) is mainly supportive as to date there is no effective antiviral treatment, apart from remdesivir which has been approved by Food and Drug administration (FDA) for treatment of COVID-19, or vaccine. Supplementation with micronutrients, such as vitamins and minerals, has gained an increasing interest as part of the supportive management of COVID-19. Vitamin C levels in serum and leukocytes are depleted during the acute stage of infection owing to increased metabolic demands. High-dose vitamin C supplement helps to normalise both serum and leukocytes vitamin C levels. Vitamin C has multiple pharmacological characteristics, antiviral, anti-oxidant, anti-inflammatory and immunomodulatory effects, which make it a potential therapeutic option in management of COVID-19. The use of high dose of intravenous vitamin C for management of COVID-19 in China and the United Stated has shown promising results. There were no reported adverse reactions with the short-term use of high dose of vitamin C. Given the fact that vitamin C is cheap, available and safe drug with beneficial effects in management of viral infections and critically ill patients reported in previous clinical trials, it is sensible to add it to COVID-19 management protocol particularly if the current ongoing clinical trials testing the effect of vitamin C in management of COVID-19 show positive results.

show abstract

Section: The Beneficial Effect Of Vitamin C In Management Of Covid-19mentioning

confidence: 99%

Section: The Beneficial Effect Of Vitamin C In Management Of Covid-19mentioning

confidence: 99%

Overview of the possible role of vitamin C in management of COVID-19

2020

View full text Add to dashboard Cite

show abstract

“…Recent studies recommended the consumption of vitamin C to control lower respiratory tract infections, and vitamin C supplementation represents one of the most compelling therapeutic interventions for COVID-19 [ 87 , 88 , 89 , 90 ]. Vitamin C’s primary function in the immune response against infections is to act as a potent antioxidant.…”

Section: Vitamins and Immune Systemmentioning

confidence: 99%

Effective Immune Functions of Micronutrients against SARS-CoV-2

et al. 2020

View full text Add to dashboard Cite

The third coronavirus outbreak in the last two decades has caused significant damage to the world’s economy and community health. The highly contagious COVID-19 infection has affected millions of people to date and has led to hundreds of thousands of deaths worldwide. Aside from the highly infectious nature of SARS-CoV-2, the lack of a treatment or vaccine has been the main reason for its spread. Thus, it has become necessary to find alternative methods for controlling SARS-CoV-2. For the present review, we conducted an online search for different available nutrition-based therapies for previously known coronavirus infections and RNA-based virus infections as well as general antiviral therapies. These treatments have promise for combating COVID-19, as various nutrients and minerals play direct and indirect roles in the control and prevention of this newly emerged viral infection. The patients’ nutritional status with COVID-19 must be analyzed before administering any treatment, and nutritional supplements should be given to the affected individuals along with routine treatment. We suggest a potential interventional role of nutrients to strengthen the immune system against the emerging infection caused by COVID-19.

show abstract

“…Under certain circumstances such as contraindications of acyclovir, vitamin C and quercetin might be considered as alternative treatments, which have been proved to display immunomodulatory function and anti-viral effect. 16 In addition, the patients with herpes zoster should be placed on contact precautions to avoid varicella zoster virus transmission to susceptible persons such as other COVID-19 patients.…”

Section: Discussionmentioning

confidence: 99%

<p>Herpes Zoster and Postherpetic Neuralgia in an Elderly Patient with Critical COVID-19: A Case Report</p>

Cao¹,

Zhang²,

Wang³

et al. 2020

JPR

View full text Add to dashboard Cite

Critical patients with COVID-19 are thought to be at high risk of developing chronic pain. However, the exact nature and mechanisms of COVID-19-related chronic pain remain largely unknown. Here, we describe clinical features, treatments and outcome of herpes zoster as well as postherpetic neuralgia in a 70-year-old woman with critical COVID-19. The patient had a history of type 2 diabetes and myasthenia gravis. She developed herpes zoster in the right 10 to 12 lumbar dermatomes in the recovery period of COVID-19. Intravenous (250 mg 3 times a day) and then oral (400 mg 5 times a day) acyclovir was used for antiviral therapy. Pregabalin (75 mg orally twice a day) and ibuprofen was used for analgesia. Her skin lesions resolved 21 days after the onset of rash. However, she continued to have persistent pain in the same dermatomal distribution. After the dosage of pregabalin was increased to 150 mg orally twice a day, her pain was partially relieved. During the telephone follow-up 4 months after herpes zoster eruption, the patient still complained intermittent pain in the right 10 to 12 lumbar dermatomes. Our case draws attention to postherpetic neuralgia in COVID-19 patients and provides a targeted suggestion for this kind of patients.

show abstract

Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)

Cited by 424 publications

References 129 publications

Overview of the possible role of vitamin C in management of COVID-19

Overview of the possible role of vitamin C in management of COVID-19

Effective Immune Functions of Micronutrients against SARS-CoV-2

<p>Herpes Zoster and Postherpetic Neuralgia in an Elderly Patient with Critical COVID-19: A Case Report</p>

Contact Info

Product

Resources

About