Quercetin as an antiinflammatory analgesic

Ferraz, Camila R.; Franciosi, Anelise; Emídio, Nayara Braga; Rasquel-Oliveira, Fernanda S.; Manchope, Marília F.; Carvalho, Thacyana T.; Artero, Nayara A.; Fattori, Victor; Vicentini, Fabiana T. M. C.; Casagrande, Rúbia; Verri, Waldiceu A.

doi:10.1016/b978-0-12-822923-1.00023-6

Cited by 9 publications

(5 citation statements)

References 110 publications

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“…Isorhamnentin-3- O -rutinoside is derived from the quercetin molecule by methylation [ 50 ]. Quercetin has a broad range of biological activities, including antioxidant, analgesic, anti-inflammatory, cardio- and neuroprotective and antiallergic activities [ 51 ].…”

Section: Resultsmentioning

confidence: 99%

Effect of Phenolic Compounds from Almond Skins Obtained by Water Extraction on Pork Patty Shelf Life

et al. 2022

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The extraction of phenols from almond skin using water has not been applied before. The purpose of this study was to obtain aqueous extracts from almond skin to be added to pork patties to prolong their shelf life. Four different varieties of almonds were studied and aqueous extracts were obtained. The antioxidant capacity and composition of phenol compounds of the extracts were determined. Results showed that the use of water produces extracts with phenol compounds and antioxidant capacity, with the Antoñeta variety presenting the best performance in terms of antioxidant behavior. The most abundant phenolic compounds identified were isorhamentin-3-O-rutinoside, catechin and protocatechuic acid, all of them had a hydrophilic character due to the –OH groups in their molecules. The effect of almond skin extracts (ALMOND) on the shelf life of pork patties was compared with the effects of a control without extract (CONTROL NEG) and a control with sodium ascorbate (CONTROL POS). Throughout storage, values of pH, weight loss, headspace composition, color, TBARs and psychrotrophic aerobic bacteria were studied. CONTROL POS samples showed the lowest lipid oxidation values in comparison to CONTROL NEG or ALMOND extract samples.

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Section: Resultsmentioning

confidence: 99%

Effect of Phenolic Compounds from Almond Skins Obtained by Water Extraction on Pork Patty Shelf Life

et al. 2022

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“…While quercetin is a flavonol with a wide range of properties such as antioxidant, anti-inflammatory, antibacterial, antiviral, gastroprotective, and immunomodulating activities. Quercetin is found in apples, citrus fruits, berries, dark cherries, cranberries, onions, broccoli, cabbage, raw asparagus, peppers, legumes, whole grains, and capers, among others ( Ferraz et al, 2021 ). Wang et al (2018a) found that resveratrol has antitumor effects by inhibiting cell proliferation and promoting cell apoptosis in NSCLC cell lines A549 and H1299.…”

Section: Modulation Of Hdacs By Natural Compounds In Lung Cancermentioning

confidence: 99%

Histone deacetylases modulate resistance to the therapy in lung cancer

et al. 2022

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The acetylation status of histones located in both oncogenes and tumor suppressor genes modulate cancer hallmarks. In lung cancer, changes in the acetylation status are associated with increased cell proliferation, tumor growth, migration, invasion, and metastasis. Histone deacetylases (HDACs) are a group of enzymes that take part in the elimination of acetyl groups from histones. Thus, HDACs regulate the acetylation status of histones. Although several therapies are available to treat lung cancer, many of these fail because of the development of tumor resistance. One mechanism of tumor resistance is the aberrant expression of HDACs. Specific anti-cancer therapies modulate HDACs expression, resulting in chromatin remodeling and epigenetic modification of the expression of a variety of genes. Thus, HDACs are promising therapeutic targets to improve the response to anti-cancer treatments. Besides, natural compounds such as phytochemicals have potent antioxidant and chemopreventive activities. Some of these compounds modulate the deregulated activity of HDACs (e.g. curcumin, apigenin, EGCG, resveratrol, and quercetin). These phytochemicals have been shown to inhibit some of the cancer hallmarks through HDAC modulation. The present review discusses the epigenetic mechanisms by which HDACs contribute to carcinogenesis and resistance of lung cancer cells to anticancer therapies.

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“…Quercetin is a bitter tasting flavonoid known for its potent antiviral, anti-carcinogenic, antioxidant, anti-inflammatory and disease-prevention abilities [ 41 , 42 , 43 , 44 ]. Structurally, quercetin is a pentahydroxyflavone containing five hydroxy groups located at the 3-, 3’-, 4’-, 5- and 7-positions [ 45 ]; it is known to be one of the most abundant flavonoids in fruit, vegetables, and red wine.…”

Section: Quercetinmentioning

confidence: 99%

Therapeutic Potential of Select Dietary Compounds in the Management of Hypertension and its Cardiovascular Complications

et al. 2022

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Hypertension is a common risk factor for cardiovascular disease and mortality worldwide. Proper nutrition and diet are known to play an indispensable role in the treatment and management of hypertension. Bioactive compounds that occur in small quantities in foods such as onions, fish and red wine are being intensively studied to uncover their vasoprotective, antioxidant, anti-proliferative and anti-inflammatory effect,s which are beneficial to attenuate chronic disease and protect human health. In this article, the anti-hypertensive, and cardio-protective effects of five food-derived bioactive compounds: resveratrol, quercetin, coenzyme Q10, DHA and EPA and their proposed mechanisms of action are reviewed in detail.

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Quercetin as an antiinflammatory analgesic

Cited by 9 publications

References 110 publications

Effect of Phenolic Compounds from Almond Skins Obtained by Water Extraction on Pork Patty Shelf Life

Effect of Phenolic Compounds from Almond Skins Obtained by Water Extraction on Pork Patty Shelf Life

Histone deacetylases modulate resistance to the therapy in lung cancer

Therapeutic Potential of Select Dietary Compounds in the Management of Hypertension and its Cardiovascular Complications

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