Quercetin associated with dimethylsulfoxide has a curative effect on experimental colon anastomosis injury

Abstract

Purpose To examine the effects of quercetin on healing of experimental colon anastomosis injury in early and late period. Methods Eighty male Wistar-Albino rats were divided into 8 groups. For all groups, left colons of the rats were resected and for the rest end-to-end anastomosis was performed. Two of the groups for which the experiment protocol was ended on the 3rd and 7th day following the anastomosis were not administered with either quercetin or dimethylsulfoxide DMSO, whereas two other groups were administered with DMSO only, and four other groups were administered with quercetin dissolved in DMSO in doses of 20 and 100 mg/kg during the protocol. At the end of the study, anastomosis line was resected, histopathological evaluation was performed and bursting pressure, malondialdehyde, superoxide dismutase, catalase, and hydroxyproline levels were measured. Results Quercetin significantly increased hydroxyproline, superoxide dismutase, catalase levels, histopathological healing score, bursting pressure values and decreased malondialdehyde level in early period. It also significantly increased superoxide dismutase, catalase, and hydroxyproline levels and decreased malondialdehyde level in late period. Conclusion It was seen that quercetin speeds up the injury healing process and reveals an antioxidant effect, specifically in early period.

Healing effects of L-carnitine on experimental colon anastomosis wound

“…Animals used in this study were anesthetized by subcutaneous injection of a mixture of Xylazine (5 mg/kg Rompun ®) and Ketamine (50 mg/kg-Ketalar®) following a 12-hour fasting [20,21]. Anesthetized animals were lied down on their back on the table with their abdomens facing up.…”

Pharmacological studies of the veterinary medicinal product “Dibutalastin Ointment”

“…Dimethylsulfoxide (DMSO) has an anti-inflammatory, local analgesic, and anti-edematous effect (Demir et al, 2020;Gkiatas & Gelalis, 2021;Sanli et al, 2021;Anzelc & Burkhart, 2021). The anti-inflammatory effect is based on several pharmacological effects, mainly the inactivation of hydroxyl radicals, which are formed in large quantities during inflammation and lead to tissue destruction.…”