Quercetin extraction from Rosa damascena Mill via supercritical CO2: Neural network and adaptive neuro fuzzy interface system modeling and response surface optimization

Ghoreishi, S.M.; Hedayati, Ali; Mousavi, Soghra

doi:10.1016/j.supflu.2016.02.006

Cited by 37 publications

(17 citation statements)

References 20 publications

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“…Quercetin (3, 5, 7, 3′, 4′-pentahydroxyflavone), a polar polyphenolic compound with a molecular formula of C 15 H 10 O 7 , is a natural flavonoid found abundantly in many edible vegetables [1,2]. Quercetin has attracted considerable attention because of its biologically important activities, such as anti-oxidant activity [3], anti-obesity effects [4], and cancer treatment potential [5,6].…”

Section: Introductionmentioning

confidence: 99%

Application of Natural Deep Eutectic Solvents in the Extraction of Quercetin from Vegetables

Dai

Row

2019

Molecules

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Quercetin is a phytochemical with disease prevention and health promotion activities that has attracted significant research attention. In this study, choline chloride and betaine-based natural deep eutectic solvents were prepared using a heating method. Their physical and chemical properties were also tested. Then, they were applied to extract quercetin from onion and broccoli with ultrasonic-assisted solid liquid method coupled with HPLC. Three factors (temperature, amount, and time) were considered for the optimization of the extraction assays. In the optimal conditions, the extraction recoveries were 88.91–98.99%, 88.45–99.01%, and 89.56–98.74% for quercetin, isorhamnetin, and kaempferol. Tailor-made natural deep eutectic solvents could be applied as sustainable and safe extraction media for biochemical applications.

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Section: Introductionmentioning

confidence: 99%

Application of Natural Deep Eutectic Solvents in the Extraction of Quercetin from Vegetables

Dai

Row

2019

Molecules

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“…For each Soxhlet extraction, 10 g of powdered 0.3 mm mean particle size Pinus brutia pinecone sample was weighted and placed into the Soxhlet equipment and continuously extracted for 7 h by using 170 ml ethanol as organic solvent. Similar Soxhlet application conditions and recovery calculations were used in the literature (Ghoreishi et al 2016b ). HPLC analysis was used for determination of QRK amounts and recoveries in the ethanolic extracts.…”

Section: Methodsmentioning

confidence: 99%

Extraction and quantification of some valuable flavonoids from pinecone of Pinus brutia via Soxhlet and Supercritical CO2 extraction: a comparison study

2021

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Graphic abstract In this study, the extraction of oil from pinecone of Pinus brutia was evaluated by supercritical CO 2 (Sc-CO 2 ) and Soxhlet extraction methods. The quercetin, rutin and kaempferol (QRK) contents of oil were analyzed one by one via HPLC. The rutin compound investigated in this study has the potential to be a drug against the COVID 19 virus. SEM and BET analysis were performed to observe the structural change and increase in surface area after Sc-CO 2 extraction. The operating conditions were investigated in the range of 35–65 °C temperatures, 140–220 bar of pressures, 0.30–1.00 mm of mean particle sizes, 3–7 l/min of CO 2 flow rates, 0–8% w/w co-solvent and 30–150 min extraction periods. When the results obtained by the Sc-CO 2 method were compared with the results of Soxhlet extraction method, the maximum recovery of total QRK was found 4.18% in co-solvent-free studies and 30.94% in co-solvent-added Sc-CO 2 studies. Sc-CO 2 extraction results of Q, R, and K were found as 14.75 ± 1.08 µg/g, 14.23 ± 1.27 µg/g, and 15.70 ± 1.13 µg/g pinecone, respectively. Soxhlet extraction results of Q, R, and K were found as 36.43 ± 2.26 μg/g, 57.19 ± 3.81 μg/g, and 50.80 ± 2.79 μg/g pinecone, respectively. The maximum amount of QRK was found as 44.68 ± 2.89 μg/g pinecone by Sc-CO 2 method via adding 8% ethanol by mass and as 144.42 ± 5.39 μg/g pinecone by Soxhlet method. According to the reference Soxhlet method efficiency, the Sc-CO 2 extraction recovery was found as 30.94%. Supplementary Information The online version contains supplementary material available at 10.1007/s11696-021-01644-5.

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“…Genetic algorithm also one of the promising tools in optimization of SFE [20][21][22][23][24]. It has been applied in determining constants in mathematical model in order to minimize error between model results and experimental data [25].…”

Section: Previous Study Applying Soft Intelligent Computing Techniquementioning

confidence: 99%

Overview of soft intelligent computing technique for supercritical fluid extraction

Idris

Markom

2020

IJAAS

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<span>Optimization of Supercritical Fluid Extraction process with mathematical modeling is essential for industrial applications. The response surface methodology (RSM) has been proven to be a useful and effective statistical method for studying the relationships between measured responses and independent factors. Recently there are growing interest in applying smart system or artificial technique to model and simulate a chemical process and also to predict, compute, classify and optimize as well as for process control. This system works by generalizing the experimental result and the process behavior and finally predict and estimate the problem. This smart system is a major assistance in the development of process from laboratory to pilot or industrial. The main advantage of intelligent systems is that the predictions can be performed easily, fast, and accurate way, which physical models unable to do. This paper shares several works that have been utilizing intelligent systems for modeling and simulating the supercritical fluid extraction process.</span>

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Quercetin extraction from Rosa damascena Mill via supercritical CO2: Neural network and adaptive neuro fuzzy interface system modeling and response surface optimization

Cited by 37 publications

References 20 publications

Application of Natural Deep Eutectic Solvents in the Extraction of Quercetin from Vegetables

Application of Natural Deep Eutectic Solvents in the Extraction of Quercetin from Vegetables

Extraction and quantification of some valuable flavonoids from pinecone of Pinus brutia via Soxhlet and Supercritical CO2 extraction: a comparison study

Overview of soft intelligent computing technique for supercritical fluid extraction

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