Quercetin loaded liposomes modified with galactosylated chitosan prevent LPS/D-GalN induced acute liver injury

Wei, Xinbo; Yang, Depeng; Zheng, Xiaohui; Zhao, Chen; Wang, Li; Fan, Yubo; Nie, Huan; Liu, Haifeng

doi:10.1016/j.msec.2021.112527

Cited by 17 publications

(12 citation statements)

References 40 publications

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“…It can link with transition metal ions and neutralize free radicals. Glutathione production within the body may be infuenced by quercetin, which is involved in the process by which SOD converts oxygen into H 2 O 2 and subsequently catalysis the breakdown of H 2 O 2 into H 2 O. GSH-Px (glutathione peroxidase) can precisely catalyze the reaction between GSH and H 2 O 2 , minimizing the production of peroxides and preserving regular physiological processes [44,45]. Quercetin can be efective in cholestatic liver injury.…”

Section: In Vivo and In Vitro Studies Numerous Studies Havementioning

confidence: 99%

A Comprehensive Review of the Pharmacological Importance of Dietary Flavonoids as Hepatoprotective Agents

Gajender

Mazumder

Sharma

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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The liver is a crucial organ that is involved in various kinds of metabolic activity and a very stable accessory gland for the digestive system. Long-term or persistent inflammation and oxidative stress due to any reasons have a substantial impact on the beginning and continuation of chronic diseases such as hepatocellular carcinoma, liver cirrhosis, liver fibrosis, and other hepatic conditions. There are many sources which can help the liver to be healthy and enhance its metabolic potential of the liver. Since the diet is rich origin of bioactive along with antioxidant chemicals including flavonoids and polyphenols, it can control different stages of inflammation and hepatic diseases. Numerous food sources, notably vegetables, nuts, fruits, cereals, beverages, and herbal medicinal plants, are rich in bioactive chemicals called flavonoids and their derivatives like Flavones, Anthocyanins, Iso-flavonoid, Flavanones, Flavanols, and Flavan-3-ols. Most recently occurred research on flavonoids has demonstrated that they can regulate hepatoprotective properties. This is because they are essential parts of pharmaceutical and nutraceutical products due to their hepatoprotective, antioxidative, and immune-modulating characteristics. However, the characteristics of their hepatoprotective impact remain unclear. The purpose of this comprehensive review is to survey the flavonoid structure and enriched sources for their hepatoprotective and antioxidant effects concerning liver toxicity or injury.

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Section: In Vivo and In Vitro Studies Numerous Studies Havementioning

confidence: 99%

A Comprehensive Review of the Pharmacological Importance of Dietary Flavonoids as Hepatoprotective Agents

Gajender

Mazumder

Sharma

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…The galactosylated CTS (GC) was synthesized according to the previously described method with some modifications. 11,26 In brief, TEMED was dissolved in DIW and the pH was adjusted to 4.5 with 1 N HCl. LBA (115 mg) was dissolved in the TEMED solution followed by the addition of EDC (30 mg) and NHS (7 mg).…”

Section: Synthesis Of Galactosylated Ctsmentioning

confidence: 99%

“…7–9 Although a variety of strategies have been proposed to modify the performance of drug-loaded nanoparticles, there are still obstacles such as efficient targeting ability and multiple therapeutic functions. 10,11…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9] Although a variety of strategies have been proposed to modify the performance of drug-loaded nanoparticles, there are still obstacles such as efficient targeting ability and multiple therapeutic functions. 10,11 Among different nanoparticles, liposomes, which consist of an aqueous core within a phospholipid bilayer sphere, have emerged as potential drug-delivery vesicles capable of carrying both lipophilic and hydrophilic drugs. 12 In addition to good biocompatibility, pharmacokinetic studies have demonstrated that liposome-based delivery systems can reduce the plasma concentration of drugs of interest and prolong their halflives.…”

Section: Introductionmentioning

confidence: 99%

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Hepatocyte-targeted delivery using oleanolic acid-loaded liposomes for enhanced hepatocellular carcinoma therapy

et al. 2023

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“…It is a critical hub for macronutrient metabolism, immune system homeostasis, blood volume modulation, endocrine system control, cholesterol homeostasis, and the breakdown of xenobiotics, including many current drugs. 1 However, liver is more susceptible to many drugs/toxins which lead towards precipitation of liver injury. Liver injury is frequently accompanied by endotoxins which causes severe damage to the hepatocytes.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of p-CA Against Acute Liver Damage Induced by LPS/D-GalN in Wistar Albino Rats

Mehdi¹,

Ahmad²,

Lodhi³

et al. 2022

DDDT

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Liver regulates metabolism of biomolecules and injury of liver causes distortion of metabolic functions. This injury may be oxidative or inflammatory induced by numerous factors including alcohol, pathogens and xenobiotics. This scientific study was planned to investigate the anti-inflammatory and anti-oxidant potential of p-coumaric acid (p-CA) on Lipopolysaccharide/ D-Galactosamine (LPS/D-GalN) induced liver injury. Methods: DPPH analysis, reducing power assay and HPLC analysis were performed during in-vitro studies of p-CA. Similarly, in-vivo experiments were performed using Wistar Albino rats. Normal control and intoxicated group received (5mL/kg normal saline p.o), standard treatment groups received ascorbic acid (100mg/kg p.o) and silymarin (25mg/kg p.o), while p-CA treatment groups received (100mg/kg p.o) for 28-days. After completion of 28-days, LPS/D-GalN injection (300 mg D-GalN/kg and 10 µg LPS/kg i.p.) was given at 6th, 12th and 24-hours to all groups except normal control group. Animals were sacrificed; serum and liver samples were harvested and subjected to biochemical and histological examinations, respectively. Results: The results revealed that p-CA possess strong antioxidant activity. Increased levels of leukocyte infiltration (TLC), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin (TBIL), lipid panel (eg TG, TC, LDL-C, VLDL-C), whereas decreased HDL-C levels noticed in LPS/D-GalN groups as compared to normal control groups. Pro-Inflammatory markers (eg TNF-α, IL-6, IL-1β) and lipid peroxidation marker, eg malondialdehyde (MDA) increased while superoxide dismutase (SOD) and reduced glutathione (GSH) levels were decreased significantly in groups treated with LPS/D-GalN. ANOVA with Bonferroni post hoc analysis was used for statistical analysis of. H&E staining was done to assess architectural abnormalities among liver cells. Conclusion:In conclusion, p-CA could ameliorate LPS/D-GalN induced hepatic injury via regulation of immune responses, liver function enzymes, lipid profile, oxidative stress and pro-inflammatory markers.

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Quercetin loaded liposomes modified with galactosylated chitosan prevent LPS/D-GalN induced acute liver injury

Cited by 17 publications

References 40 publications

A Comprehensive Review of the Pharmacological Importance of Dietary Flavonoids as Hepatoprotective Agents

A Comprehensive Review of the Pharmacological Importance of Dietary Flavonoids as Hepatoprotective Agents

Hepatocyte-targeted delivery using oleanolic acid-loaded liposomes for enhanced hepatocellular carcinoma therapy

Protective Effects of p-CA Against Acute Liver Damage Induced by LPS/D-GalN in Wistar Albino Rats

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