Quercetin loading CdSe/ZnS nanoparticles as efficient antibacterial and anticancer materials

Yang, Xiaofang; Zhang, Weiwei; Zhao, Zhiwei; Li, Nuan; Mou, Zhipeng; Sun, Dongdong; Cai, Yongping; Wang, Weiyun; Lin, Yi

doi:10.1016/j.jinorgbio.2016.11.023

Cited by 83 publications

(33 citation statements)

References 45 publications

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“…Among the 10 CML-related compounds, luteolin (MW � 286. 25 [26][27][28], including our study [18]. Additionally, luteolin exhibited an antibacterial action that suppressed the activity of bacterial DNA topoisomerases 1 and 2 and reduced the synthesis of nucleic acids and proteins [29] and was also known to have antioxidant, anticancer, anti-inflammatory, and neuroprotective effects [30].…”

Section: Collecting 10 Cml-related Active Compounds and Systemic Pharmentioning

confidence: 78%

Systemic Pharmacological Approach to Identification and Experimental Verification of the Effect of Anisi Stellati Fructus Extract on Chronic Myeloid Leukemia Cells

Kim

Suh

Ahn

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Anisi stellati fructus (ASF) is the dried fruit of the Illicium verum Hook.f. tree. e aim of this research was to evaluate the antileukemic effect of ASF on chronic myeloid leukemia (CML) cells, which was hypothesized from the systemic pharmacological analysis of ASF, focusing on the combined effect of ASF extract (ASFE) and imatinib (IM). e compounds of ASF were identified using the Traditional Chinese Medicine Systems Pharmacology database and analysis platform. e target gene information was acquired from the UniProt database. e compound and target interaction network was generated from Cytoscape 3.7.1. Using this analysis, 10 compounds effective against CML cells were obtained. ASFE was prepared and analyzed by high-pressure liquid chromatography to provide experimental proof for the relationship between ASF and CML. e anti-p210 Bcr-Abl effects of ASFE and ASFE + IM combination were evaluated by western blotting. Either ASFE alone or in combined treatment with IM on K-562 CML cells resulted in a significant reduction of the Bcr-Abl levels. As expected from the systemic analysis results, ASF had antileukemic activity, showing that it is a potential therapy for CML.

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Section: Collecting 10 Cml-related Active Compounds and Systemic Pharmentioning

confidence: 78%

Systemic Pharmacological Approach to Identification and Experimental Verification of the Effect of Anisi Stellati Fructus Extract on Chronic Myeloid Leukemia Cells

Kim

Suh

Ahn

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…The anticancer activity assay was focused on the proliferation and migration of BGC-823 cells, which showed an increase in cytotoxicity of two-to sixfold compared to raw QE and CdSe QDs. 28 For the enhanced targeted delivery of 5-fluorouracil (5-FU), the model proposed by Bwatanglang et al made use of folate receptors expressed in malignant tissues. Mn:ZnS QDs were encapsulated in chitosan (CS) biopolymer and functionalized with folic acid (FA).…”

Section: Drug Deliverymentioning

confidence: 99%

Quantum dots in imaging, drug delivery and sensor applications

Matea

Mocan

Tabaran

et al. 2017

IJN

527

231

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Quantum dots (QDs), also known as nanoscale semiconductor crystals, are nanoparticles with unique optical and electronic properties such as bright and intensive fluorescence. Since most conventional organic label dyes do not offer the near-infrared (>650 nm) emission possibility, QDs, with their tunable optical properties, have gained a lot of interest. They possess characteristics such as good chemical and photo-stability, high quantum yield and size-tunable light emission. Different types of QDs can be excited with the same light wavelength, and their narrow emission bands can be detected simultaneously for multiple assays. There is an increasing interest in the development of nano-theranostics platforms for simultaneous sensing, imaging and therapy. QDs have great potential for such applications, with notable results already published in the fields of sensors, drug delivery and biomedical imaging. This review summarizes the latest developments available in literature regarding the use of QDs for medical applications.

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“…Cell adhesion was monitored using a real-time cell electronic sensing system (RT-CES; ACEA Biosciences, Inc.) every 10 min for 75 h. To determine cell adhesion, each well in the plate was seeded with cells (1.0 × 10 4 cells/well) with a fresh medium to a final volume of 200 μL and then incubated in an Apt-Au@MSL solution at varying concentrations (10, 20, and 30 μg/mL) at 10 h incubated for 12 h [29]. The blank group consisted of untreated cells, and the control groups consisted of the Morin and Morin-liposome groups.…”

Section: Cell Culturementioning

confidence: 99%

Designing Aptamer-Gold Nanoparticle-Loaded pH-Sensitive Liposomes Encapsulate Morin for Treating Cancer

et al. 2020

Self Cite

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This study proposes the synthesis of a type of anticancer nanoparticle, aptamers and Au nanoparticle (Apt-Au)modified Morin pH-sensitive liposome (MSL), which exhibits targeting properties. Tumors are difficult to cure because their microenvironment varies from that of normal tissue; its pH is lower than that of normal tissue, which generally impedes the effectiveness of drugs. Thus, pH-responsive drugs have attracted extensive attention. Gold nanoparticles (AuNPs) show potential as drug carriers because of their small size, good biocompatibility, easy surface modification, and strong cell penetration. Apt-Au@MSL exhibits excellent monodispersity and tumor-targeting properties and can be released in partly acidic environment via dialysis. We screened our model cancer cell by MTT assay and found that SGC-7901 cells can effectively suppress proliferation. In vivo results demonstrate that the administration of Apt-Au@MSL could inhibit tumor growth in xenograft mouse models. H&E staining and TUNEL assay further confirmed that Apt-Au@MSL can promote tumor apoptosis. Apt-Au@MSL may induce apoptosis by triggering overproduction of reactive oxygen species (ROS) and regulating multiple signal crosstalk. Both blood biochemistry tests and H&E staining suggested that these materials exhibit negligible acute toxicity and good biocompatibility in vivo. With its powerful function, Apt-Au@MSL can be used as a target-based anticancer material for future clinical cancer treatment.

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Quercetin loading CdSe/ZnS nanoparticles as efficient antibacterial and anticancer materials

Cited by 83 publications

References 45 publications

Systemic Pharmacological Approach to Identification and Experimental Verification of the Effect of Anisi Stellati Fructus Extract on Chronic Myeloid Leukemia Cells

Systemic Pharmacological Approach to Identification and Experimental Verification of the Effect of Anisi Stellati Fructus Extract on Chronic Myeloid Leukemia Cells

Quantum dots in imaging, drug delivery and sensor applications

Designing Aptamer-Gold Nanoparticle-Loaded pH-Sensitive Liposomes Encapsulate Morin for Treating Cancer

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